INT4805

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Context Info
Confidence 0.55
First Reported 1992
Last Reported 2006
Negated 5
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.32
Pain Relevance 5.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (TPSAB1) extracellular space (TPSAB1) extracellular region (TPSAB1)
Anatomy Link Frequency
mast cells 6
skin 4
bladder 2
HLMC 2
TPSAB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Buprenorphine 17 99.98 Very High Very High Very High
Morphine 16 99.88 Very High Very High Very High
Codeine 3 99.68 Very High Very High Very High
narcan 3 98.32 Very High Very High Very High
antagonist 1 97.96 Very High Very High Very High
Opioid 25 97.52 Very High Very High Very High
Ultiva 1 96.28 Very High Very High Very High
rapifen 1 95.24 Very High Very High Very High
opiate 1 92.56 High High
ketamine 4 92.00 High High
Disease Link Frequency Relevance Heat
Pruritus 1 97.16 Very High Very High Very High
Stress 2 77.04 Quite High
Adverse Drug Reaction 2 75.00 Quite High
Anaphylaxis 1 69.24 Quite High
Pain 1 50.00 Quite Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Interstitial Cystitis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The majority of general anesthetics and RCM tested induced only the release of preformed mediators (histamine and tryptase), not of the de novo synthesized eicosanoids.
Neg (not) Positive_regulation (induced) of Localization (release) of tryptase
1) Confidence 0.55 Published 1996 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 8645973 Disease Relevance 0.14 Pain Relevance 0.09
In contrast, buprenorphine caused histamine and tryptase release from HLMC, and not from HSMC, whilst it also induced de novo synthesis of PGD2 and LTC4 in HLMC.
Neg (not) Positive_regulation (caused) of Localization (release) of tryptase in HLMC associated with buprenorphine
2) Confidence 0.53 Published 1993 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 7690200 Disease Relevance 0 Pain Relevance 0.49
Only codeine and meperidine induced mast cell activation with the release of tryptase and histamine, leading to protein extravasation, flare reactions, and itch sensations.
Positive_regulation (induced) of Localization (release) of tryptase in mast cell associated with pruritus and codeine
3) Confidence 0.47 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 14742371 Disease Relevance 0.10 Pain Relevance 1.49
Morphine only induced histamine and tryptase release from HSMC, but not the de novo synthesis of PGD2.
Neg (not) Positive_regulation (induced) of Localization (release) of tryptase in HSMC associated with morphine
4) Confidence 0.46 Published 1993 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 7690200 Disease Relevance 0 Pain Relevance 0.50
Stress-induced release of tryptase and histamine, but not of prostaglandin D2 and water flux, was greater in food-allergic patients than in healthy volunteers.
Positive_regulation (induced) of Localization (release) of tryptase
5) Confidence 0.41 Published 1998 Journal Gastroenterology Section Body Doc Link 9516384 Disease Relevance 0.08 Pain Relevance 0
Morphine (10(-5)-3 x 10(-4) M), in a concentration-dependent manner, induced histamine and tryptase release from skin but not from lung mast cells, up to a maximum of 18.2 +/- 1.9% and 13.0 +/- 4.1 micrograms/10(7) cells, respectively.
Positive_regulation (induced) of Localization (release) of tryptase in skin associated with morphine
6) Confidence 0.38 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1280014 Disease Relevance 0 Pain Relevance 0.91
Buprenorphine (10(-6)-10(-4) M), in a concentration-dependent manner, caused histamine and tryptase release from lung but not from skin mast cells, to a maximum of 47.6 +/- 7.2% and 35.1 +/- 13.6 micrograms/10(7) cells, respectively.
Neg (not) Positive_regulation (caused) of Localization (release) of tryptase in mast cells associated with buprenorphine
7) Confidence 0.38 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1280014 Disease Relevance 0 Pain Relevance 1.00
Fentanyl (10(-5)-10(-3) M) did not induce histamine and tryptase release or the de novo synthesis of PGD2 or LTC4 from any mast cells.
Neg (not) Positive_regulation (induce) of Localization (release) of tryptase in mast cells
8) Confidence 0.38 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1280014 Disease Relevance 0 Pain Relevance 0.90
RESULTS: The immediate increase in prostacyclin release from thrombin or tryptase stimulated human bladder microvascular endothelial cells depended on the activation of membrane associated calcium independent phospholipase A2, resulting in an increase in arachidonic acid production.
Positive_regulation (increase) of Localization (release) of tryptase in bladder
9) Confidence 0.24 Published 2006 Journal J. Urol. Section Body Doc Link 16952710 Disease Relevance 0 Pain Relevance 0

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