INT4806

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Context Info
Confidence 0.80
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 29
Total Number 29
Disease Relevance 5.05
Pain Relevance 10.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (TPSAB1) extracellular space (TPSAB1) extracellular region (TPSAB1)
Anatomy Link Frequency
mast cells 11
skin 3
basophils 2
bladder 1
bowel 1
TPSAB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Versed 10 99.82 Very High Very High Very High
Buprenorphine 32 99.56 Very High Very High Very High
Nerve growth factor 1 99.48 Very High Very High Very High
Morphine 31 99.44 Very High Very High Very High
Codeine 10 98.92 Very High Very High Very High
Opioid 49 98.78 Very High Very High Very High
Inflammation 8 98.40 Very High Very High Very High
interstitial cystitis 5 97.60 Very High Very High Very High
opioid receptor 4 97.56 Very High Very High Very High
ketamine 10 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 98.40 Very High Very High Very High
Cancer 1 98.36 Very High Very High Very High
Necrosis 1 98.12 Very High Very High Very High
Interstitial Cystitis 5 97.60 Very High Very High Very High
Pruritus 2 97.16 Very High Very High Very High
Anaphylaxis 111 94.84 High High
Allergic Dermatitis 4 93.80 High High
Inflammatory Bowel Disease 2 93.72 High High
Blister 4 89.88 High High
Alagille Syndrome 4 87.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This new approach allowed us to measure the dose-dependent release of histamine and tryptase from mast cells and the subsequent vascular and sensory effect without systemic side effects in volunteers.
Localization (release) of tryptase in mast cells
1) Confidence 0.80 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 14742371 Disease Relevance 0.07 Pain Relevance 1.17
However, such a plateau of histamine (but not tryptase) release occurred after an initial C challenge if Ag was subsequently incubated in a continuous fashion.
Localization (release) of tryptase
2) Confidence 0.80 Published 1990 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 1695232 Disease Relevance 0 Pain Relevance 0
A solid phase immunoradiometric assay was developed for the quantitation of tryptase released from activated human mast cells.
Localization (released) of tryptase in mast cells
3) Confidence 0.80 Published 1991 Journal J. Immunol. Methods Section Abstract Doc Link 2019745 Disease Relevance 0 Pain Relevance 0
The in vitro release of histamine induced by anesthetic drugs and RCM was correlated with the release of tryptase.
Localization (release) of tryptase
4) Confidence 0.74 Published 1996 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 8645973 Disease Relevance 0.07 Pain Relevance 0.07
Only codeine and meperidine induced mast cell activation with the release of tryptase and histamine, leading to protein extravasation, flare reactions, and itch sensations.
Localization (release) of tryptase in mast cell associated with pruritus and codeine
5) Confidence 0.71 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 14742371 Disease Relevance 0.10 Pain Relevance 1.48
There was peak release of both histamine and tryptase during the first hour of Ag incubation (89 +/- 11 ng/ml and 1428 +/- 260 ng/ml, respectively).
Localization (release) of tryptase
6) Confidence 0.70 Published 1990 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 1695232 Disease Relevance 0.25 Pain Relevance 0.09
Challenge of continuous Ag-incubation sites with C, a mast cell activator, led to another peak release of both histamine and tryptase.
Localization (release) of tryptase in mast cell
7) Confidence 0.70 Published 1990 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 1695232 Disease Relevance 0.20 Pain Relevance 0.07
-protryptase, which is secreted constitutively [29].
Localization (secreted) of tryptase
8) Confidence 0.68 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873621 Disease Relevance 1.38 Pain Relevance 0
The majority of general anesthetics and RCM tested induced only the release of preformed mediators (histamine and tryptase), not of the de novo synthesized eicosanoids.
Localization (release) of tryptase
9) Confidence 0.64 Published 1996 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 8645973 Disease Relevance 0.14 Pain Relevance 0.09
In contrast, buprenorphine caused histamine and tryptase release from HLMC, and not from HSMC, whilst it also induced de novo synthesis of PGD2 and LTC4 in HLMC.
Localization (release) of tryptase in HLMC associated with buprenorphine
10) Confidence 0.62 Published 1993 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 7690200 Disease Relevance 0 Pain Relevance 0.46
Stress-induced release of tryptase and histamine, but not of prostaglandin D2 and water flux, was greater in food-allergic patients than in healthy volunteers.
Localization (release) of tryptase
11) Confidence 0.62 Published 1998 Journal Gastroenterology Section Body Doc Link 9516384 Disease Relevance 0.08 Pain Relevance 0
Release of histamine and tryptase during continuous and interrupted cutaneous challenge with allergen in humans.
Localization (Release) of tryptase
12) Confidence 0.61 Published 1990 Journal J. Allergy Clin. Immunol. Section Title Doc Link 1695232 Disease Relevance 0.27 Pain Relevance 0.09
The recent development of in vitro techniques to study the release of preformed (histamine and tryptase) and de novo synthesized mediators (PGD2, LTC4, and PAF) from purified basophils and mast cells has made it possible to quantify the mediator-releasing activity of anesthetics such as muscle relaxants, general anesthetics, opioids, and benzodiazepines and RCM on human basophils and mast cells isolated from lung, skin and heart tissues.
Localization (release) of tryptase in skin associated with opioid
13) Confidence 0.56 Published 1996 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 8645973 Disease Relevance 0.16 Pain Relevance 0.09
Morphine only induced histamine and tryptase release from HSMC, but not the de novo synthesis of PGD2.
Localization (release) of tryptase in HSMC associated with morphine
14) Confidence 0.54 Published 1993 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 7690200 Disease Relevance 0 Pain Relevance 0.50
Fentanyl did not give any histamine and tryptase release from mast cells.
Localization (release) of tryptase in mast cells
15) Confidence 0.54 Published 1993 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 7690200 Disease Relevance 0 Pain Relevance 0.27
Tryptase released from elevated numbers of activated mast cells is a proposed mediator of the inflammatory process in IC.
Localization (released) of Tryptase in mast cells associated with inflammation and interstitial cystitis
16) Confidence 0.50 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15937147 Disease Relevance 0.67 Pain Relevance 0.51
A study was performed about the effects of increasing concentrations of muscle relaxants (suxamethonium, d-tubocurarine, vecuronium, and atracurium), hypnotics (propofol, ketamine, and thiopental), opioids (morphine, buprenorphine, and fentanyl), and benzodiazepines (diazepam, flunitrazepam, and midazolam) on the release of preformed (histamine and tryptase) and de novo synthesized (prostaglandin D2: PGD2 and peptide-leukotriene C4: LTC4) chemical mediators from human basophils and mast cells isolated from skin (HSMC), lung parenchyma (HLMC) and heart tissue (HHMC).
Localization (release) of tryptase in basophils associated with versed, ketamine, opioid, buprenorphine and morphine
17) Confidence 0.47 Published 1993 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 7690200 Disease Relevance 0 Pain Relevance 0.39
Fentanyl (10(-5)-10(-3) M) did not induce histamine and tryptase release or the de novo synthesis of PGD2 or LTC4 from any mast cells.
Localization (release) of tryptase in mast cells
18) Confidence 0.44 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1280014 Disease Relevance 0 Pain Relevance 0.89
Morphine (10(-5)-3 x 10(-4) M), in a concentration-dependent manner, induced histamine and tryptase release from skin but not from lung mast cells, up to a maximum of 18.2 +/- 1.9% and 13.0 +/- 4.1 micrograms/10(7) cells, respectively.
Localization (release) of tryptase in skin associated with morphine
19) Confidence 0.44 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1280014 Disease Relevance 0 Pain Relevance 0.90
Buprenorphine (10(-6)-10(-4) M), in a concentration-dependent manner, caused histamine and tryptase release from lung but not from skin mast cells, to a maximum of 47.6 +/- 7.2% and 35.1 +/- 13.6 micrograms/10(7) cells, respectively.
Localization (release) of tryptase in mast cells associated with buprenorphine
20) Confidence 0.44 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1280014 Disease Relevance 0 Pain Relevance 0.99

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