INT48064

Context Info Confidence 0.01 First Reported 1995 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 1.04 Pain Relevance 0.36

USHBP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Clonidine 2 99.98 COX-2 inhibitor 2 79.64 cerebral cortex 1 77.20 cytokine 14 62.72 Enkephalin 2 25.00 cINOD 2 19.56 aspirin 1 17.64 Inflammation 4 5.00 Central nervous system 2 5.00 chemokine 2 5.00

Disease Link Frequency Relevance Heat Stomach Cancer 24 92.40 Cancer 81 90.92 Acquired Immune Deficiency Syndrome Or Hiv Infection 141 62.52 Malignant Neoplastic Disease 4 48.84 Apoptosis 9 47.16 Infection 11 39.92 Disease 9 27.84 INFLAMMATION 6 19.32 Dementia 9 5.00 Immunodeficiency 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A recent in vitro study demonstrated that wild type p53 inhibits the formation of the complex between TATA binding protein and the promoter region of COX-2 gene in a cell-free system (18).

binding protein Binding (formation) of

1) Confidence 0.01 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721998 Disease Relevance 0.92 Pain Relevance 0.04

IR-receptor proteins have also been immunodetected using an antibody raised against an approximately 70-kD idazoxan/clonidine binding protein, which probably recognizes all types of IRs.

binding protein Binding (recognizes) of associated with clonidine

2) Confidence 0.00 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15028606 Disease Relevance 0 Pain Relevance 0.23

The reduction of LTR expression is possibly explained by the binding of methyl-CpG-binding protein 1 complex and methyl-CpG-binding protein 2 to methylated Sp1 transcription factor binding sites, thereby inhibiting the binding of Sp1 transcription factors [282,283].

binding protein Binding (binding) of

3) Confidence 0.00 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.12 Pain Relevance 0.09

The CRE-binding protein (CREB) binds CRE-1, but binding there is entirely dependent on the presence of CRE-2.

CRE-binding protein Binding (binds) of

4) Confidence 0.00 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7499237 Disease Relevance 0 Pain Relevance 0

General Comments

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