INT48066

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Context Info
Confidence 0.36
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.69
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CAMP)
Anatomy Link Frequency
epidermis 1
CAMP (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 2 99.34 Very High Very High Very High
psoriasis 91 96.20 Very High Very High Very High
tolerance 1 95.64 Very High Very High Very High
Inflammation 45 87.16 High High
cytokine 33 77.52 Quite High
Arthritis 10 60.00 Quite High
corticosteroid 3 32.00 Quite Low
withdrawal 1 12.76 Low Low
Etanercept 37 5.00 Very Low Very Low Very Low
Infliximab 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 118 100.00 Very High Very High Very High
Injury 5 94.76 High High
Dermatitis 30 91.92 High High
INFLAMMATION 47 87.16 High High
Disease 27 84.32 Quite High
Hyperplasia 1 69.84 Quite High
Congenital Anomalies 3 69.48 Quite High
Parakeratosis 1 64.60 Quite High
Acanthosis 1 62.88 Quite High
Cancer 11 62.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DNA structure determines protein binding and transcriptional efficiency of the proenkephalin cAMP-responsive enhancer.
cAMP Binding (binding) of associated with enkephalin
1) Confidence 0.36 Published 1995 Journal J. Biol. Chem. Section Title Doc Link 7499237 Disease Relevance 0 Pain Relevance 0.20
The overexpressed LL37 binds to extracellular self-DNA and forms aggregates that enter pDCs, activate TLR 9, and trigger type I IFN production.
LL37 Binding (binds) of
2) Confidence 0.09 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 1.38 Pain Relevance 0.36
According to this study, the antimicrobial peptide cathelicidin, LL37, which is strongly represented in psoriatic lesions (Ong et al 2002), binds to the DNA leaked from damaged cells in the lesional epidermis and forms an immunogenic complex that breaks tolerance and induces the production of IFN-?
LL37 Binding (binds) of in epidermis associated with psoriasis and tolerance
3) Confidence 0.07 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727880 Disease Relevance 1.31 Pain Relevance 0.37

General Comments

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