INT48075

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 71
Total Number 72
Disease Relevance 48.63
Pain Relevance 40.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
macrophages 7
plasma 2
nerve 2
Schwann cells 2
striatum 1
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 313 100.00 Very High Very High Very High
cytokine 188 100.00 Very High Very High Very High
Spinal cord 9 100.00 Very High Very High Very High
spinal inflammation 4 100.00 Very High Very High Very High
anakinra 22 99.90 Very High Very High Very High
Eae 16 99.82 Very High Very High Very High
Nerve growth factor 39 99.80 Very High Very High Very High
antagonist 38 99.72 Very High Very High Very High
Sciatic nerve 34 99.68 Very High Very High Very High
Enkephalin 8 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 278 100.00 Very High Very High Very High
Cancer 113 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 65 100.00 Very High Very High Very High
Pressure And Volume Under Development 56 100.00 Very High Very High Very High
Necrosis 26 100.00 Very High Very High Very High
Low Back Pain 4 100.00 Very High Very High Very High
Urological Neuroanatomy 2 100.00 Very High Very High Very High
Disease 160 99.96 Very High Very High Very High
Injury 49 99.82 Very High Very High Very High
Toxicity 26 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a murine model of CL we report on evident hyperalgesia, as assessed by acute pain tests, and sustained upregulation of interleukin (IL-1beta) and nerve growth factor (NGF).
Positive_regulation (upregulation) of IL-1beta in nerve associated with leishmaniasis, hyperalgesia, nerve growth factor and acute pain
1) Confidence 0.67 Published 2000 Journal Pain Section Abstract Doc Link 10781922 Disease Relevance 0.99 Pain Relevance 0.85
The effects of intraarticular IL-1beta induction were subsequently evaluated at the cellular, histopathologic, and behavioral levels.
Positive_regulation (induction) of IL-1beta
2) Confidence 0.67 Published 2006 Journal Arthritis Rheum. Section Body Doc Link 16572453 Disease Relevance 0 Pain Relevance 0
Mice with CL showed sustained increase in the levels of IL-1beta and NGF which were reversed by thymulin (1 microg).
Positive_regulation (increase) of IL-1beta associated with leishmaniasis and nerve growth factor
3) Confidence 0.67 Published 2002 Journal Brain Behav. Immun. Section Abstract Doc Link 12096890 Disease Relevance 0.92 Pain Relevance 0.80
In conclusion, this study shows that, during early infection, the low dose of L. major causes hyperalgesia accompanied by an upregulation of IL-1beta and IL-6 and that these effects are reversed within the first two weeks of infection.
Positive_regulation (upregulation) of IL-1beta associated with hyperalgesia and infection
4) Confidence 0.67 Published 2006 Journal Exp. Parasitol. Section Abstract Doc Link 16516198 Disease Relevance 1.44 Pain Relevance 0.68
This hyperalgesia is accompanied by a sustained upregulation of interleukin-1beta (IL-1beta) and an early upregulation of interleukin-6 (IL-6) which is restored to normal levels after five days of infection.
Positive_regulation (upregulation) of IL-1beta associated with hyperalgesia and infection
5) Confidence 0.67 Published 2006 Journal Exp. Parasitol. Section Abstract Doc Link 16516198 Disease Relevance 1.45 Pain Relevance 0.73
Conversely, pair-housed animals treated with a selective oxytocin receptor antagonist developed depressive-like behavior equivalent to that of socially isolated animals and displayed increased IL-1beta protein levels within the frontal cortex.
Positive_regulation (increased) of IL-1beta in frontal cortex
6) Confidence 0.67 Published 2010 Journal Psychosom Med Section Body Doc Link 20466999 Disease Relevance 0 Pain Relevance 0
We found an ipsilateral upregulation of TNF, IL-1beta and IL-10 mRNA levels as early as one hour after CCI.
Positive_regulation (upregulation) of IL-1beta associated with eae
7) Confidence 0.67 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17204395 Disease Relevance 1.07 Pain Relevance 0.74
IL-1beta is increased early in acetaminophen toxicity and may be important in iNOS induction.
Positive_regulation (increased) of IL-1beta associated with toxicity and paracetamol
8) Confidence 0.67 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 14625346 Disease Relevance 0.79 Pain Relevance 0.69
Murine nucleus pulposus synthesizes increased amounts of IL-1beta, IL-6, IL-10, and granulocyte-macrophage colony-stimulating factor in response to lipopolysaccharide stimulation.
Positive_regulation (increased) of IL-1beta in macrophage
9) Confidence 0.67 Published 2003 Journal Spine Section Body Doc Link 14673370 Disease Relevance 0.07 Pain Relevance 0
In experimental animal models of PD, IL-1beta level was increased and NGF one decreased in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonian mice, and TNF-alpha level was increased in the substantia nigra and striatum of the 6-hydroxydopamine (6OHDA)-injected side of hemiparkinsonian rats.
Positive_regulation (increased) of IL-1beta in striatum associated with parkinson's disease, nerve growth factor, substantia nigra and disease
10) Confidence 0.67 Published 2000 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 11205147 Disease Relevance 1.28 Pain Relevance 0.60
At this time, a significant increase in lung levels of TNF-alpha and IL-1beta was also observed.
Positive_regulation (increase) of IL-1beta in lung
11) Confidence 0.67 Published 2006 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 16798781 Disease Relevance 0.98 Pain Relevance 0.78
Infection with a high dose of Leishmania major has been shown to induce hyperalgesia in BALB/c mice accompanied by a sustained upregulation of Interleukin-1beta (IL-1beta) and an early upregulation of Interleukin-6 (IL-6).
Positive_regulation (upregulation) of IL-1beta associated with hyperalgesia and infection
12) Confidence 0.67 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17184847 Disease Relevance 0.54 Pain Relevance 0.38
KA-induced gliosis and proinflammatory marker (COX-2, IL-1beta, and TNF-alpha) inductions were also suppressed by fluoxetine administration.
Positive_regulation (inductions) of IL-1beta associated with gliosis and fluoxetine
13) Confidence 0.67 Published 2009 Journal Brain Res. Section Abstract Doc Link 19427844 Disease Relevance 0.73 Pain Relevance 1.18
When murine J774 macrophages were incubated with the sesquiterpene lactone, LPS-induced IL-1beta, tumor necrosis factor-alpha (TNF-alpha) and keratinocyte-derived chemokine (KC) release were concentration-dependently inhibited.
Positive_regulation (induced) of IL-1beta in keratinocyte associated with chemokine, necrosis and cancer
14) Confidence 0.67 Published 2009 Journal Phytomedicine Section Abstract Doc Link 19524419 Disease Relevance 0.66 Pain Relevance 0.36
IL-1beta levels were increased in the tibial region of osteosarcoma-bearing mice and in the paws of inflamed mice.
Positive_regulation (increased) of IL-1beta associated with osteogenic sarcomas
15) Confidence 0.67 Published 2007 Journal Life Sci. Section Abstract Doc Link 17692876 Disease Relevance 1.40 Pain Relevance 1.05
A more rapid and transient pattern of transgene up-regulation in the PVN followed administration of intraperitoneal IL-1beta (10 microg/kg) with significant induction by 2 hours, peak levels reached by 4 hours, and a return toward basal levels by 6 hours.
Positive_regulation (induction) of IL-1beta in PVN
16) Confidence 0.67 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10023810 Disease Relevance 0.07 Pain Relevance 0.03
Mice subjected to renal IR under isoflurane anesthesia also showed a reduction in inflammation evidenced by a reduced renal influx of neutrophils and macrophages, reduced ICAM-1 expression, less upregulation of proinflammatory mRNAs (TNF-alpha, ICAM-1, KC, and IL-1beta) as well as reduced nuclear translocation of NF-kappaB 24 h after renal IR injury.
Positive_regulation (upregulation) of IL-1beta in neutrophils associated with anesthesia, inflammation, injury and isoflurane
17) Confidence 0.67 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17596528 Disease Relevance 1.33 Pain Relevance 1.07
DH was also associated with increased IL-1beta concentrations in cortex (at 24 and 48 h) and cerebellum (24 h) as compared to UH and Con.
Positive_regulation (increased) of IL-1beta in cerebellum
18) Confidence 0.67 Published 2005 Journal Brain Behav. Immun. Section Abstract Doc Link 15913952 Disease Relevance 0.37 Pain Relevance 0.21
Human MSCs reduced the mRNA levels of the pro-inflammatory interleukin IL-1beta mouse gene, as well as the neural beta-galactosidase over-activation in prefrontal cortex of SNI mice.
Positive_regulation (activation) of IL-1beta in prefrontal associated with inflammation
19) Confidence 0.67 Published 2010 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 19937263 Disease Relevance 1.13 Pain Relevance 0.65
MDL-28170, but not (+)-MK-801 inhibited TNF and IL-1beta upregulation one hour after CCI.
Positive_regulation (upregulation) of IL-1beta associated with eae
20) Confidence 0.67 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17204395 Disease Relevance 0.98 Pain Relevance 0.69

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