INT48076

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 3.46
Pain Relevance 6.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
THP-1 4
peritoneal macrophages 4
peritoneal cavity 2
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 27 100.00 Very High Very High Very High
cytokine 18 100.00 Very High Very High Very High
agonist 10 100.00 Very High Very High Very High
Enkephalin 8 100.00 Very High Very High Very High
antagonist 20 99.98 Very High Very High Very High
narcan 9 99.84 Very High Very High Very High
Dopamine 1 99.32 Very High Very High Very High
Analgesic 13 98.62 Very High Very High Very High
opioid receptor 2 97.84 Very High Very High Very High
Neurotransmitter 1 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 19 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
Pain 5 91.52 High High
Pressure And Volume Under Development 3 88.88 High High
Targeted Disruption 3 83.92 Quite High
Nervous System Injury 1 79.68 Quite High
Neuropathic Pain 5 78.96 Quite High
Nociception 5 77.84 Quite High
Hypersensitivity 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The enhanced release of IL-1 beta caused by ME or LPS was partially blocked by naloxone.
Negative_regulation (blocked) of Localization (release) of IL-1 beta associated with narcan and enkephalin
1) Confidence 0.59 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7499497 Disease Relevance 0 Pain Relevance 0.83
A-740003 potently blocked agonist-evoked IL-1beta release (IC(50) = 156 nM) and pore formation (IC(50) = 92 nM) in differentiated human THP-1 cells.
Negative_regulation (blocked) of Localization (release) of IL-1beta in THP-1 associated with agonist
2) Confidence 0.57 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16982702 Disease Relevance 0.74 Pain Relevance 1.01
Systemic treatment of mice with a panel of melanocortin peptides inhibited IL-1 beta release and PMN accumulation elicited by urate crystals in the murine peritoneal cavity.
Negative_regulation (inhibited) of Localization (release) of IL-1 beta in peritoneal cavity
3) Confidence 0.57 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12626592 Disease Relevance 0.30 Pain Relevance 0.48
Fittingly, Dyn was not antianalgesic in C3H/HeJ mice, which are genetically deficient in release of IL1beta.
Negative_regulation (deficient) of Localization (release) of IL1beta
4) Confidence 0.57 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11602679 Disease Relevance 0 Pain Relevance 0.75
A-804598 also potently blocked agonist stimulated release of IL-1beta and Yo-Pro uptake from differentiated THP-1 cells that natively express human P2X7 receptors.
Negative_regulation (blocked) of Localization (release) of IL-1beta in THP-1 associated with agonist
5) Confidence 0.57 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 18602931 Disease Relevance 0.34 Pain Relevance 0.51
IL-4, -10, or -13 significantly inhibited the release of both tumor necrosis factor (TNF)-alpha (60, 53, and 100%, respectively) and IL-1beta (80, 100, and 100%, respectively) by mice peritoneal macrophages obtained after local (i.p.) injection of zymosan.
Negative_regulation (inhibited) of Localization (release) of IL-1beta in peritoneal macrophages associated with necrosis and cancer
6) Confidence 0.41 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12490580 Disease Relevance 0.37 Pain Relevance 0.81
This analgesic effect could be related to a peripheral mechanism, probably via the inhibition of the release of the pro-inflammatory cytokines TNF-alpha and IL-1beta by resident peritoneal macrophages.
Negative_regulation (inhibition) of Localization (release) of IL-1beta in peritoneal macrophages associated with inflammation, analgesic and cytokine
7) Confidence 0.41 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12490580 Disease Relevance 0.38 Pain Relevance 0.77
Budlein A also inhibited the carrageenan-induced release of TNF-alpha (52%), KC (70%) and IL-1beta (59%).
Negative_regulation (inhibited) of Localization (release) of IL-1beta
8) Confidence 0.41 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17320857 Disease Relevance 0.71 Pain Relevance 0.47
Moreover, B(1) but not B(2) kinin receptor antagonist inhibited carrageenin-induced hypernociception, and TNF-alpha and IL-1beta release as well, in LPS-primed mice.
Negative_regulation (inhibited) of Localization (release) of IL-1beta associated with antagonist
9) Confidence 0.41 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17669394 Disease Relevance 0.35 Pain Relevance 0.72
Antigen-induced release of IL-1beta and KC/CXCL1 was reduced in TNFR1-/- mice, and TNF-alpha-induced hypernociception was inhibited by IL-1ra and reparixin.
Negative_regulation (reduced) of Localization (release) of IL-1beta
10) Confidence 0.05 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.28 Pain Relevance 0.24

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