INT48077

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 8.80
Pain Relevance 7.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
peritoneal cavity 2
cardiac myocyte 2
THP-1 2
pore 2
brain 2
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 31 100.00 Very High Very High Very High
agonist 8 99.98 Very High Very High Very High
Inflammation 44 99.84 Very High Very High Very High
Spinal cord 5 99.68 Very High Very High Very High
Enkephalin 21 99.56 Very High Very High Very High
antagonist 15 99.00 Very High Very High Very High
Dopamine 1 98.76 Very High Very High Very High
Central nervous system 1 98.68 Very High Very High Very High
narcan 15 98.16 Very High Very High Very High
anakinra 6 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 2 100.00 Very High Very High Very High
Bone Cancer 2 99.90 Very High Very High Very High
Injury 12 99.88 Very High Very High Very High
INFLAMMATION 30 99.84 Very High Very High Very High
Burns 24 99.74 Very High Very High Very High
Hyperalgesia 9 98.96 Very High Very High Very High
Crystal Associated Disease 4 98.60 Very High Very High Very High
Necrosis 5 97.74 Very High Very High Very High
Cancer 4 97.56 Very High Very High Very High
Death 1 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The enhanced release of IL-1 beta caused by ME or LPS was partially blocked by naloxone.
Positive_regulation (enhanced) of Localization (release) of IL-1 beta associated with narcan and enkephalin
1) Confidence 0.69 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7499497 Disease Relevance 0 Pain Relevance 0.82
Adding ME alone or together with LPS to the culture increased the release of IL-1 beta after 48 h in a concentration-dependent fashion.
Positive_regulation (increased) of Localization (release) of IL-1 beta associated with enkephalin
2) Confidence 0.69 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7499497 Disease Relevance 0 Pain Relevance 0.71
However, IL-1beta release was significantly increased in CAP/DNFB mice over O/DNFB by 18-fold and by over 30-fold compare to O/O controls.
Positive_regulation (increased) of Localization (release) of IL-1beta
3) Confidence 0.67 Published 1998 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9878594 Disease Relevance 0.27 Pain Relevance 0.25
Burn trauma promoted cardiac myocyte secretion of tumor necrosis factor (TNFalpha) (175+/-6 pg/mL) compared to that measured in shams (72+/-9 pg/mL, P < 0.05); burn trauma also increased cardiac myocyte secretion of interleukin 1beta (IL-1beta) (sham: 2+/-0.5; burn: 22+/-1 pg/mL, P < 0.05) and IL-6 (sham: 70+/-6; burn: 148+/-16 pg/mL, P < 0.05).
Positive_regulation (increased) of Localization (secretion) of IL-1beta in cardiac myocyte associated with necrosis, cancer, burns and injury
4) Confidence 0.67 Published 2001 Journal Shock Section Abstract Doc Link 11508864 Disease Relevance 2.20 Pain Relevance 0.06
Systemic treatment of mice with a panel of melanocortin peptides inhibited IL-1 beta release and PMN accumulation elicited by urate crystals in the murine peritoneal cavity.
Positive_regulation (elicited) of Localization (release) of IL-1 beta in peritoneal cavity
5) Confidence 0.67 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12626592 Disease Relevance 0.30 Pain Relevance 0.48
Despite increasing IL-1 beta release into the media, ME (10(-8) M) did not induce morphological changes in microglia.
Positive_regulation (increasing) of Localization (release) of IL-1 beta in microglia associated with enkephalin
6) Confidence 0.50 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7499497 Disease Relevance 0 Pain Relevance 0.83
A-804598 also potently blocked agonist stimulated release of IL-1beta and Yo-Pro uptake from differentiated THP-1 cells that natively express human P2X7 receptors.
Positive_regulation (stimulated) of Localization (release) of IL-1beta in THP-1 associated with agonist
7) Confidence 0.49 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 18602931 Disease Relevance 0.34 Pain Relevance 0.50
In conclusion, some hyperalgesic symptoms observed in this model of bone cancer are mediated by the peripheral release of IL-1beta and may be inhibited by antagonists of type I IL-1 receptors with a similar or greater potency than symptoms produced by inflammation.
Positive_regulation (mediated) of Localization (release) of IL-1beta associated with hyperalgesia, inflammation, antagonist, bone cancer and potency
8) Confidence 0.49 Published 2007 Journal Life Sci. Section Abstract Doc Link 17692876 Disease Relevance 1.53 Pain Relevance 1.22
Budlein A also inhibited the carrageenan-induced release of TNF-alpha (52%), KC (70%) and IL-1beta (59%).
Positive_regulation (carrageenan-induced) of Localization (release) of IL-1beta
9) Confidence 0.49 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17320857 Disease Relevance 0.71 Pain Relevance 0.47
Activation of P2X(7) receptors leads to rapid changes in intracellular calcium concentrations, release of the proinflammatory cytokine interleukin-1beta (IL-1beta), and following prolonged agonist exposure, cytolytic plasma membrane pore formation.
Positive_regulation (leads) of Localization (release) of IL-1beta in pore associated with agonist and cytokine
10) Confidence 0.49 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16982702 Disease Relevance 0.43 Pain Relevance 0.44
The Dyn response is mediated by release of IL1beta in the spinal cord to activate an ascending pathway to the brain and in turn releases IL1beta in the brain which activates a descending pathway to the spinal cord.
Positive_regulation (mediated) of Localization (release) of IL1beta in brain associated with spinal cord
11) Confidence 0.49 Published 2002 Journal Life Sci. Section Abstract Doc Link 11860156 Disease Relevance 0 Pain Relevance 0.55
BACKGROUND: Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystal-induced interleukin 1 beta (IL1beta) release contributes to inflammation in subcutaneous air pouch and peritoneal models of acute gout and pseudogout.
Positive_regulation (induced) of Localization (release) of IL1beta associated with inflammation and crystal associated disease
12) Confidence 0.19 Published 2009 Journal Ann. Rheum. Dis. Section Abstract Doc Link 19528034 Disease Relevance 0.69 Pain Relevance 0.24
Consistently, antigen challenge induced a time-dependent release of TNF-alpha, IL-1beta and KC/CXCL-1 in IM, but not in SI, mice.
Positive_regulation (dependent) of Localization (release) of IL-1beta
13) Confidence 0.06 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.28 Pain Relevance 0.23
Consistently, antigen challenge induced a time-dependent release of TNF-alpha, IL-1beta and KC/CXCL-1 in IM, but not in SI, mice.
Neg (not) Positive_regulation (induced) of Localization (release) of IL-1beta
14) Confidence 0.06 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.28 Pain Relevance 0.23
Together, these results suggest that inflammation associated with an adaptive immune response induces hypernociception that is mediated by an initial release of TNF-alpha, which triggers the subsequent release of IL-1beta and KC/CXCL1.
Positive_regulation (triggers) of Localization (release) of IL-1beta associated with inflammation
15) Confidence 0.05 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.17 Pain Relevance 0.22
Antigen-induced release of IL-1beta and KC/CXCL1 was reduced in TNFR1-/- mice, and TNF-alpha-induced hypernociception was inhibited by IL-1ra and reparixin.
Positive_regulation (induced) of Localization (release) of IL-1beta
16) Confidence 0.04 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.27 Pain Relevance 0.24
These molecules mediate the regulation of nuclear factor-kappa B (NF-kappa B) activation, cell apoptosis, and interleukin-1 beta secretion through cross-regulated and, sometimes, common signaling pathways.
Positive_regulation (mediate) of Localization (secretion) of interleukin-1 beta associated with apoptosis
17) Confidence 0.01 Published 2004 Journal Am J Pharmacogenomics Section Abstract Doc Link 15059033 Disease Relevance 1.34 Pain Relevance 0.18

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