INT48078

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Context Info
Confidence 0.62
First Reported 1993
Last Reported 2010
Negated 6
Speculated 3
Reported most in Abstract
Documents 15
Total Number 18
Disease Relevance 14.78
Pain Relevance 9.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
macrophages 6
brain 4
blood 2
liver 2
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 53 100.00 Very High Very High Very High
cytokine 37 100.00 Very High Very High Very High
Paracetamol 35 100.00 Very High Very High Very High
Inflammatory response 7 100.00 Very High Very High Very High
sSRI 3 100.00 Very High Very High Very High
Endogenous opioid 1 99.98 Very High Very High Very High
cINOD 7 99.84 Very High Very High Very High
Serotonin 3 99.84 Very High Very High Very High
Nerve growth factor 6 99.80 Very High Very High Very High
ketamine 16 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 57 100.00 Very High Very High Very High
Cancer 12 100.00 Very High Very High Very High
Adhesions 10 100.00 Very High Very High Very High
Nociception 9 100.00 Very High Very High Very High
Necrosis 7 100.00 Very High Very High Very High
Appetite Loss 3 100.00 Very High Very High Very High
Urological Neuroanatomy 2 99.84 Very High Very High Very High
Viral Meningitis 8 99.76 Very High Very High Very High
Granuloma 4 99.76 Very High Very High Very High
Bacterial Respiratory Disease 2 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data indicate that both exogenous and endogenous opioids regulate IL-1 beta production by microglial cells in the mixed brain cell cultures.
Regulation (regulate) of Gene_expression (production) of IL-1 beta in brain associated with endogenous opioid
1) Confidence 0.62 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7499497 Disease Relevance 0 Pain Relevance 0.77
Administration of ketamine alone did not influence TNF-alpha, IL-1beta, or IL-6 mRNA production.
Neg (not) Regulation (influence) of Gene_expression (production) of IL-1beta associated with ketamine
2) Confidence 0.60 Published 2005 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 15781291 Disease Relevance 0.14 Pain Relevance 0.71
This model will be useful for investigating the mechanisms controlling the production of IL-1 beta from the mRNA level to the secretion of mature biologically active protein [1], and in the search for new drugs which could selectively interfere with this process.
Spec (investigating) Regulation (controlling) of Gene_expression (production) of IL-1 beta
3) Confidence 0.57 Published 1993 Journal Agents Actions Section Abstract Doc Link 8213352 Disease Relevance 0.45 Pain Relevance 0.14
The anti-inflammatory mechanism of MDT might be related to the decreases in the level of MDA in the edema paw via increasing the activities of SOD and GRd in the liver, and the NO level via regulating the IL-1beta production and the level of TNF-alpha in the inflamed tissues.
Regulation (regulating) of Gene_expression (production) of IL-1beta in liver associated with pressure and volume under development and inflammation
4) Confidence 0.44 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19606516 Disease Relevance 1.13 Pain Relevance 0.47
Furafylline, a CYP1A inhibitor, and indomethacin, a PGHS inhibitor, exhibited a significant inhibitory effect on TNFalpha and IL-1beta production induced by the APAP and LPS combination.
Regulation (effect) of Gene_expression (production) of IL-1beta associated with paracetamol
5) Confidence 0.44 Published 2009 Journal J Immunotoxicol Section Abstract Doc Link 19589095 Disease Relevance 0.19 Pain Relevance 1.25
We investigated the effect of subtoxic concentrations of acetaminophen in conjunction with bacterial lipopolysaccharide (LPS) on the expression of the pro-inflammatory cytokines TNFalpha and IL-1beta using the mouse macrophage cell line RAW264.7 as a model.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of IL-1beta in macrophage associated with paracetamol, inflammation and cytokine
6) Confidence 0.44 Published 2009 Journal J Immunotoxicol Section Abstract Doc Link 19589095 Disease Relevance 0.37 Pain Relevance 1.01
Conversely, PAG had no effect on LPS-induced production of the hypernociceptive cytokines, TNF-alpha, IL-1beta and CXCL1/KC and on hypernociception induced by PGE(2), a directly acting hypernociceptive mediator.
Neg (no) Regulation (effect) of Gene_expression (production) of IL-1beta associated with urological neuroanatomy and cytokine
7) Confidence 0.44 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18585702 Disease Relevance 0.51 Pain Relevance 0.12
Our objective was to characterize the molecular mechanisms responsible for the hepatic inflammatory response to time-limited TNF-alpha and IL-1beta expression.
Regulation (response) of Gene_expression (expression) of IL-1beta associated with inflammatory response
8) Confidence 0.44 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17656447 Disease Relevance 0.29 Pain Relevance 0.22
No effects were observed on IL-1beta or MCP-1 expression.
Neg (No) Regulation (effects) of Gene_expression (expression) of IL-1beta
9) Confidence 0.44 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 16081117 Disease Relevance 1.31 Pain Relevance 1.08
TNF-alpha and IL-1beta production in the supernatant were, on average, 30% lower in the ispilateral group than in the contralateral group.
Regulation (lower) of Gene_expression (production) of IL-1beta
10) Confidence 0.44 Published 2005 Journal Br J Anaesth Section Body Doc Link 15863437 Disease Relevance 0 Pain Relevance 0
Serum levels of the inflammatory cytokines IL-1beta and IL-6, mediators of cachexia, were modulated by NSAIDs.
Regulation (modulated) of Gene_expression (levels) of IL-1beta associated with appetite loss, inflammation, cinod and cytokine
11) Confidence 0.44 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 15170663 Disease Relevance 1.94 Pain Relevance 0.48
Thereafter, recruited macrophages contributed to the production of TNFalpha, IL-1alpha, and IL-1beta, which in turn augmented myelin phagocytosis by macrophages.
Regulation (contributed) of Gene_expression (production) of IL-1beta in macrophages
12) Confidence 0.44 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.56 Pain Relevance 0.36
Interestingly, Abeta(1-40) activated macrophages treated with AS605240 or another PI3Kgamma inhibitor, AS252424, displayed impaired chemotaxis in vitro, but their expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unaffected.
Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of IL-1beta in macrophages associated with necrosis, cancer and abeta
13) Confidence 0.44 Published 2010 Journal Brain Behav. Immun. Section Abstract Doc Link 20025958 Disease Relevance 1.36 Pain Relevance 0.58
The effects of three anti-inflammatory or immunosuppressive drugs, prednisolone, indomethacin and cyclosporin A, on IL-1 beta and PGE2 production in zymosan and Bordetella-pertussis-vaccine (BPV)-challenged tissue chambers were also examined.
Spec (examined) Regulation (effects) of Gene_expression (production) of IL-1 beta associated with bordatella infection, inflammation and bacterial respiratory disease
14) Confidence 0.42 Published 1993 Journal Agents Actions Section Abstract Doc Link 8213352 Disease Relevance 0.81 Pain Relevance 0.25
In addition, the effects of 5-HT2AR agonist 2,5-dimethoxy-4-iodoamphetamine (DOI), and the selective serotonin reuptake inhibitors (SSRIs) citalopram and fluoxetine, were tested on nickel-stimulated peripheral blood mononuclear cells from nickel-allergic patients, regarding their proliferation and interleukin (IL)-2 production, as well as the effect of these SSRIs on a murine Langerhans' cell-like line (XS52), regarding its IL-1beta production.
Regulation (effect) of Gene_expression (production) of IL-1beta in blood associated with hypersensitivity, agonist, ssri and fluoxetine
15) Confidence 0.26 Published 2007 Journal Acta Derm. Venereol. Section Abstract Doc Link 17721644 Disease Relevance 0.26 Pain Relevance 0.42
Injection of thymulin only did not alter the nociceptive thresholds or the levels of IL-1beta and NGF.
Neg (not) Regulation (alter) of Gene_expression (levels) of IL-1beta associated with nociception and nerve growth factor
16) Confidence 0.26 Published 2002 Journal Brain Behav. Immun. Section Abstract Doc Link 12096890 Disease Relevance 0.89 Pain Relevance 0.79
Although intraplantar PAR-2 activation-induced oedema is also TRPV1 receptor-mediated, primary mechanical hyperalgesia, impaired weight distribution and IL-1beta production are independent of this channel.
Neg (independent) Regulation (independent) of Gene_expression (production) of IL-1beta associated with pressure and volume under development and hyperalgesia
17) Confidence 0.26 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19683949 Disease Relevance 1.14 Pain Relevance 0.71
The expression of interleukin-1 (IL-1 beta, IL-6, IL-10), tumor necrosis factors-alpha (TNF alpha), vascular endothelial growth factor (VEGF), and adhesion molecules (E-selectin, intracellular cell adhesion molecule (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1)) in encephalitic brains of mice and humans was evaluated by semi-quantitative polymerase chain reaction (PCR).
Regulation (evaluated) of Gene_expression (expression) of IL-1 beta in brains associated with necrosis, cancer and adhesions
18) Confidence 0.11 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9475112 Disease Relevance 2.43 Pain Relevance 0.18

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