INT4808

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Context Info
Confidence 0.73
First Reported 1987
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 37
Total Number 38
Disease Relevance 18.36
Pain Relevance 9.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (LTC4S) nuclear envelope (LTC4S) small molecule metabolic process (LTC4S)
lyase activity (LTC4S) endoplasmic reticulum (LTC4S) nucleus (LTC4S)
Anatomy Link Frequency
eosinophils 4
neutrophils 4
Basophils 3
mast cells 3
HLMC 3
LTC4S (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 301 100.00 Very High Very High Very High
Cluster headache 16 99.84 Very High Very High Very High
Buprenorphine 16 99.56 Very High Very High Very High
Opioid 22 98.72 Very High Very High Very High
Morphine 19 98.72 Very High Very High Very High
aspirin 125 98.04 Very High Very High Very High
Inflammatory marker 12 97.92 Very High Very High Very High
agonist 18 97.16 Very High Very High Very High
cINOD 41 94.72 High High
ketamine 4 94.20 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 370 100.00 Very High Very High Very High
Cluster Headache 16 99.84 Very High Very High Very High
Urticaria 41 99.32 Very High Very High Very High
Asthma 284 98.56 Very High Very High Very High
Rhinitis 273 97.68 Very High Very High Very High
Cough 77 97.64 Very High Very High Very High
Hypersensitivity 74 97.48 Very High Very High Very High
Pressure And Volume Under Development 101 97.00 Very High Very High Very High
Arthropathy 2 95.48 Very High Very High Very High
Malabsorption Syndromes 2 93.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of salmeterol and nimesulide on chemotaxis and synthesis of PAF and LTC4 by human eosinophils.
Gene_expression (synthesis) of LTC4 in eosinophils
1) Confidence 0.73 Published 1996 Journal Eur Respir J Suppl Section Title Doc Link 8871060 Disease Relevance 0.09 Pain Relevance 0.21
However, at comparable concentrations, only nimesulide was able to inhibit the synthesis of PAF and LTC4 in activated eosinophils.
Gene_expression (synthesis) of LTC4 in eosinophils
2) Confidence 0.73 Published 1996 Journal Eur Respir J Suppl Section Abstract Doc Link 8871060 Disease Relevance 0.07 Pain Relevance 0.18
In the present study, we have, therefore, measured the effect of salmeterol and nimesulide on two important human eosinophil functions: chemotaxis; and synthesis of PAF and leukotriene C4 (LTC4).
Gene_expression (synthesis) of leukotriene C4 in eosinophil
3) Confidence 0.73 Published 1996 Journal Eur Respir J Suppl Section Abstract Doc Link 8871060 Disease Relevance 0.07 Pain Relevance 0.19
In the present study, we have, therefore, measured the effect of salmeterol and nimesulide on two important human eosinophil functions: chemotaxis; and synthesis of PAF and leukotriene C4 (LTC4).
Gene_expression (synthesis) of LTC4 in eosinophil
4) Confidence 0.73 Published 1996 Journal Eur Respir J Suppl Section Abstract Doc Link 8871060 Disease Relevance 0.07 Pain Relevance 0.19
Buprenorphine also induced de novo synthesis of PGD2 and LTC4 from lung mast cells.
Gene_expression (synthesis) of LTC4 in mast cells associated with buprenorphine
5) Confidence 0.72 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1280014 Disease Relevance 0 Pain Relevance 0.96
Fentanyl (10(-5)-10(-3) M) did not induce histamine and tryptase release or the de novo synthesis of PGD2 or LTC4 from any mast cells.
Gene_expression (synthesis) of LTC4 in mast cells
6) Confidence 0.72 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1280014 Disease Relevance 0 Pain Relevance 0.88
In contrast, buprenorphine caused histamine and tryptase release from HLMC, and not from HSMC, whilst it also induced de novo synthesis of PGD2 and LTC4 in HLMC.
Gene_expression (synthesis) of LTC4 in HLMC associated with buprenorphine
7) Confidence 0.70 Published 1993 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 7690200 Disease Relevance 0 Pain Relevance 0.30
The muscle relaxants and hypnotics examined did not induce any de novo synthesis of PGD2 or LTC4 in mast cells.
Gene_expression (synthesis) of LTC4 in mast cells
8) Confidence 0.70 Published 1993 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 7690200 Disease Relevance 0 Pain Relevance 0.50
Basophils released < 5% of their histamine content and did not synthesize significant amounts of LTC4 when incubated with any of the opioids.
Neg (not) Gene_expression (synthesize) of LTC4 in Basophils associated with opioid
9) Confidence 0.63 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1280014 Disease Relevance 0 Pain Relevance 0.83
Mastalerz et al. demonstrated the overproduction of Cys-LT in association with the LTC4S polymorphism in chronic urticaria patients with aspirin sensitivity.34 The frequency of subjects carrying the C allele of LTC4S-444A > C was significantly higher in chronic urticaria patients who tested positive in the aspirin challenge test than those who tested negative.
Gene_expression (overproduction) of LTC4S associated with urticaria and aspirin
10) Confidence 0.55 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 1.50 Pain Relevance 0.29
It has been suggested that the activity of the leukotriene C4 synthase gene (LTC4S), a key enzyme in Cys-LT synthesis, is genetically regulated in the pathogenesis of AIA.
Gene_expression (synthesis) of LTC4S associated with asthma
11) Confidence 0.55 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 1.00 Pain Relevance 0.11
NIM (10(-6) to 10(-3) M) markedly inhibited the de novo synthesis of LTC4 from basophils, LTC4 and PGD2 from HLMC and PGD2 from HSMC.
Gene_expression (synthesis) of LTC4 in HLMC
12) Confidence 0.51 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7505332 Disease Relevance 0.07 Pain Relevance 0.28
Cross-linking of the high-affinity receptor for IgE (Fc epsilon RI) by a polyclonal anti-Fc epsilon antibody caused the release of preformed (histamine and tryptase) and de novo synthesized mediators [peptide leukotriene C4 (LTC4) and prostaglandin D2 (PGD2)].
Gene_expression (synthesized) of LTC4
13) Confidence 0.48 Published 1995 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 7536502 Disease Relevance 0.33 Pain Relevance 0.16
Cross-linking of the high-affinity receptor for IgE (Fc epsilon RI) by a polyclonal anti-Fc epsilon antibody caused the release of preformed (histamine and tryptase) and de novo synthesized mediators [peptide leukotriene C4 (LTC4) and prostaglandin D2 (PGD2)].
Gene_expression (synthesized) of peptide leukotriene C4
14) Confidence 0.48 Published 1995 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 7536502 Disease Relevance 0.33 Pain Relevance 0.16
Maximal stimulation of HHMC with anti-IgE led to the release of LTC4 (17.5 +/- 5.1 ng/10(6) mast cells) and PGD2 (17.8 +/- 5.0 ng/10(6) mast cells, whereas HSMC synthesized more PGD2 (65.0 +/- 6.8 ng/10(6) mast cells) and much less LTC4 (< 5 ng/10(6) cells).
Gene_expression (synthesized) of LTC4 in HSMC
15) Confidence 0.48 Published 1995 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 7536502 Disease Relevance 0.26 Pain Relevance 0.20
NIM (10(-6) to 10(-3) M) markedly inhibited the de novo synthesis of LTC4 from basophils, LTC4 and PGD2 from HLMC and PGD2 from HSMC.
Gene_expression (synthesis) of LTC4 in HLMC
16) Confidence 0.44 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7505332 Disease Relevance 0.07 Pain Relevance 0.28
Basophil histamine release and leukotriene (LTB4-LTC4) production in cluster headache.
Gene_expression (production) of LTC4 in Basophil associated with cluster headache
17) Confidence 0.40 Published 1989 Journal Headache Section Title Doc Link 2466813 Disease Relevance 0.57 Pain Relevance 0.57
Histamine release and leukotrienes (LTB4 and LTC4) production from circulating basophil have been studied in 13 patients with episodic cluster headache (CH) during the remission phase of symptoms, and in 9 normal subjects.
Gene_expression (production) of LTC4 in basophil associated with cluster headache
18) Confidence 0.40 Published 1989 Journal Headache Section Abstract Doc Link 2466813 Disease Relevance 0.39 Pain Relevance 0.39
Cellular production of 5-lipoxygenase products was inhibited by SK&F 86002 as measured by leukotriene B4 (LTB4) generation from human neutrophils (IC50 20 microM), leukotriene C4 (LTC4) generation by human monocytes (IC50 20 microM), and 5-HETE production by RBL-1 cells (IC50 40 microM).
Gene_expression (production) of leukotriene C4 in neutrophils
19) Confidence 0.27 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 2823821 Disease Relevance 0.56 Pain Relevance 0.24
Cellular production of 5-lipoxygenase products was inhibited by SK&F 86002 as measured by leukotriene B4 (LTB4) generation from human neutrophils (IC50 20 microM), leukotriene C4 (LTC4) generation by human monocytes (IC50 20 microM), and 5-HETE production by RBL-1 cells (IC50 40 microM).
Gene_expression (generation) of LTC4 in neutrophils
20) Confidence 0.27 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 2823821 Disease Relevance 0.54 Pain Relevance 0.23

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