INT48080

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Context Info
Confidence 0.50
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.30
Pain Relevance 4.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 7 99.96 Very High Very High Very High
Hyperalgesia 12 99.92 Very High Very High Very High
dorsal root ganglion 5 99.52 Very High Very High Very High
antagonist 3 97.40 Very High Very High Very High
Neuropathic pain 5 97.16 Very High Very High Very High
Sciatic nerve 5 95.40 Very High Very High Very High
aspirin 1 94.28 High High
Pain 4 94.16 High High
substance P 6 94.04 High High
narcan 5 93.52 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 16 99.92 Very High Very High Very High
Ganglion Cysts 5 99.52 Very High Very High Very High
Infection 16 99.08 Very High Very High Very High
Neuropathic Pain 8 97.16 Very High Very High Very High
Pain 4 94.16 High High
Leishmaniasis 2 78.96 Quite High
INFLAMMATION 2 75.00 Quite High
Nervous System Injury 1 75.00 Quite High
Mycobacterium Infection 2 74.56 Quite High
Inflammatory Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization studies showed that LPS, but not ME, increased the abundance of IL-1 beta mRNA.
Positive_regulation (increased) of Positive_regulation (abundance) of IL-1 beta mRNA associated with enkephalin
1) Confidence 0.50 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7499497 Disease Relevance 0 Pain Relevance 0.81
This hyperalgesia is accompanied by a sustained upregulation of interleukin-1beta (IL-1beta) and an early upregulation of interleukin-6 (IL-6) which is restored to normal levels after five days of infection.
Positive_regulation (restored) of Positive_regulation (upregulation) of IL-1beta associated with hyperalgesia and infection
2) Confidence 0.49 Published 2006 Journal Exp. Parasitol. Section Abstract Doc Link 16516198 Disease Relevance 1.46 Pain Relevance 0.73
This hyperalgesia is accompanied by a sustained upregulation of interleukin-1beta (IL-1beta) and an early upregulation of interleukin-6 (IL-6) which is restored to normal levels after five days of infection.
Positive_regulation (accompanied) of Positive_regulation (upregulation) of IL-1beta associated with hyperalgesia and infection
3) Confidence 0.49 Published 2006 Journal Exp. Parasitol. Section Abstract Doc Link 16516198 Disease Relevance 1.46 Pain Relevance 0.73
PSL-induced IL-1beta up-regulation was suppressed by anti-MIP-1alpha and siRNA against CCR1 and CCR5.
Positive_regulation (induced) of Positive_regulation (up-regulation) of IL-1beta
4) Confidence 0.45 Published 2010 Journal Pain Section Abstract Doc Link 20223588 Disease Relevance 0.97 Pain Relevance 1.16
The effect of IL-1beta was Ca(2+)-dependent and significantly inhibited by 100 ng/ml IL-1 receptor-specific antagonist (IL-1r antagonist), cyclooxygenase (COX) inhibitors such as 0.1 mM aspirin, 1 microg/ml indomethacin, and 1 microM NS-398 (specific for COX-2), and 1 microM dexamethasone.
Positive_regulation (-dependent) of Positive_regulation (effect) of IL-1beta associated with aspirin, antagonist and dexamethasone
5) Confidence 0.02 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10537081 Disease Relevance 0.41 Pain Relevance 0.74

General Comments

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