INT481

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Context Info
Confidence 0.62
First Reported 1975
Last Reported 2006
Negated 8
Speculated 6
Reported most in Abstract
Documents 37
Total Number 43
Disease Relevance 5.95
Pain Relevance 11.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren) extracellular space (Ren) extracellular region (Ren)
intracellular (Ren) response to stress (Ren)
Anatomy Link Frequency
plasma 8
submandibular gland 4
kidney 4
blood 4
brain 2
Ren (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 43 100.00 Very High Very High Very High
anesthesia 34 100.00 Very High Very High Very High
adenocard 22 99.98 Very High Very High Very High
bradykinin 8 99.84 Very High Very High Very High
cva 9 99.68 Very High Very High Very High
narcan 8 99.56 Very High Very High Very High
Intracerebroventricular 12 99.52 Very High Very High Very High
cocaine 26 99.28 Very High Very High Very High
antagonist 3 99.14 Very High Very High Very High
local anesthetic 8 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypotension 6 100.00 Very High Very High Very High
Natriuresis 1 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 12 99.72 Very High Very High Very High
Hemorrhage 7 99.68 Very High Very High Very High
Bordatella Infection 18 99.26 Very High Very High Very High
Hypertension 9 98.16 Very High Very High Very High
Bartter Syndrome 8 96.72 Very High Very High Very High
Heart Rate Under Development 4 96.48 Very High Very High Very High
INFLAMMATION 1 95.88 Very High Very High Very High
Cerebral Aneurysm 1 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rat submandibular gland extract (100 microliters) did not affect the release of active renin but stimulated the release of inactive renin significantly (p less than 0.05 vs. control).
Neg (not) Regulation (affect) of Localization (release) of renin in submandibular gland
1) Confidence 0.62 Published 1990 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 2118863 Disease Relevance 0 Pain Relevance 0
The manner in which this inhibitory mechanism affects renin release under physiological circumstances remains to be demonstrated.
Regulation (affects) of Localization (release) of renin
2) Confidence 0.62 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 41729 Disease Relevance 0 Pain Relevance 0.25
During an investigation of the role of the mediobasal hypothalamus in the regulation of renin secretion from the kidneys, we found that lesions of the ventromedial nuclei prevented the increase in plasma renin activity produced by p-chloroamphetamine.
Regulation (regulation) of Localization (secretion) of renin in plasma
3) Confidence 0.62 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 3041306 Disease Relevance 0 Pain Relevance 0.07
Relation of the ventromedial nuclei of the hypothalamus to the regulation of renin secretion.
Regulation (regulation) of Localization (secretion) of renin in hypothalamus
4) Confidence 0.62 Published 1988 Journal Neuroendocrinology Section Title Doc Link 3041306 Disease Relevance 0 Pain Relevance 0.08
Since survival after hemorrhage is increased by inhibitors of the renin-angiotensin system, we asked whether anesthetic agents altered renin release during hemorrhage.
Spec (whether) Regulation (altered) of Localization (release) of renin associated with cva
5) Confidence 0.62 Published 1979 Journal Circ. Shock Section Abstract Doc Link 498431 Disease Relevance 0.65 Pain Relevance 0.44
The effect of clonidine HCl on basal and isoprenaline-stimulated renin secretion was examined in the isolated rat kidney. 2.
Regulation (effect) of Spec (examined) Localization (secretion) of renin in kidney associated with clonidine
6) Confidence 0.62 Published 1975 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 1236608 Disease Relevance 0 Pain Relevance 0.41
Pertussis toxin enhances the beta-adrenergic and blocks the alpha 2-adrenergic regulation of renin secretion in renal cortical slices.
Regulation (regulation) of Localization (secretion) of renin associated with bordatella infection
7) Confidence 0.61 Published 1986 Journal Life Sci. Section Title Doc Link 3005789 Disease Relevance 0.37 Pain Relevance 0.16
The adrenergic regulation of renin secretion was studied in renal cortical slices from control and pertussis toxin-treated rats.
Regulation (regulation) of Localization (secretion) of renin associated with bordatella infection
8) Confidence 0.61 Published 1986 Journal Life Sci. Section Abstract Doc Link 3005789 Disease Relevance 0.34 Pain Relevance 0.13
Naloxone (1.5 microM) did not affect the basal secretion of renin by isolated cortical slices from untreated rats.
Neg (not) Regulation (affect) of Localization (secretion) of renin associated with narcan
9) Confidence 0.61 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3059819 Disease Relevance 0.16 Pain Relevance 0.44
Calcium antagonists, verapamil and nifedipine, attenuated the responses of renin release to NE, ME and PE, in a concentration-dependent manner.
Regulation (responses) of Localization (release) of renin associated with antagonist
10) Confidence 0.60 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2989497 Disease Relevance 0 Pain Relevance 0.25
Recent in vitro studies have suggested that activation of A1- and A2- adenosine receptors results in opposite effects on renin secretion.
Regulation (effects) of Localization (secretion) of renin associated with adenocard
11) Confidence 0.58 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3028172 Disease Relevance 0 Pain Relevance 0.56
Exogenous adenosine affects renal hemodynamics, renal tubular transport processes, and the secretion of renin.
Regulation (affects) of Localization (secretion) of renin associated with adenocard
12) Confidence 0.58 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3028172 Disease Relevance 0 Pain Relevance 0.39
Effect of propranolol on renin release in the dog.
Regulation (Effect) of Localization (release) of renin associated with anesthesia
13) Confidence 0.58 Published 1977 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 902149 Disease Relevance 0.27 Pain Relevance 0.10
Our data indicates that pertussis toxin blocks the alpha 2-adrenergic modulation of renin release and magnifies the ability of beta adrenergic activation to stimulate PRA.
Regulation (modulation) of Localization (release) of renin associated with bordatella infection
14) Confidence 0.57 Published 1984 Journal Life Sci. Section Abstract Doc Link 6090844 Disease Relevance 0.25 Pain Relevance 0.14
Relation of central alpha-adrenoceptor and other receptors to the control of renin secretion.
Regulation (control) of Localization (secretion) of renin
15) Confidence 0.57 Published 1983 Journal Chest Section Title Doc Link 6129946 Disease Relevance 0 Pain Relevance 0.19
Isoproterenol (10(-5)M) stimulated the release of active renin significantly (p less than 0.01 vs. control) but did not affect the release of inactive renin.
Neg (not) Regulation (affect) of Localization (release) of renin
16) Confidence 0.54 Published 1990 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 2118863 Disease Relevance 0 Pain Relevance 0
Propranolol alters renin release during nitroprusside-induced hypotension and prevents hypertension on discontinuation of nitroprusside.
Regulation (alters) of Localization (release) of renin associated with hypertension and hypotension
17) Confidence 0.49 Published 1981 Journal Anesth. Analg. Section Title Doc Link 7020487 Disease Relevance 0.46 Pain Relevance 0.27
Renin release by pentobarbital anesthesia in the rat: a role for vascular mechanisms.
Regulation (role) of Localization (release) of Renin associated with anesthesia
18) Confidence 0.45 Published 1982 Journal Life Sci. Section Title Doc Link 7040889 Disease Relevance 0.17 Pain Relevance 0.57
We conclude that the tetrodotoxin-sensitive component of veratrine-stimulated renin secretion in this preparation is an in vitro model of renal nerve-stimulated renin secretion; it should be useful in investigating substances which affect renin secretion by presynaptic modulation of transmitter release.
Spec (investigating) Regulation (affect) of Localization (secretion) of renin in renal nerve associated with tetrodotoxin
19) Confidence 0.45 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6368797 Disease Relevance 0 Pain Relevance 0.19
[Release mechanisms of inactive renin from rat renal cortical slices: role of the submandibular gland].
Regulation (role) of Localization ([Release) of renin in submandibular gland
20) Confidence 0.45 Published 1990 Journal Nippon Naibunpi Gakkai Zasshi Section Title Doc Link 2118863 Disease Relevance 0 Pain Relevance 0.08

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