INT48106

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.14
Pain Relevance 2.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (LBR) small molecule metabolic process (LBR) nucleus (LBR)
DNA binding (LBR)
Anatomy Link Frequency
lymphocytes 1
THP-1 1
PBMC 1
LBR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 18 99.38 Very High Very High Very High
rheumatoid arthritis 463 98.32 Very High Very High Very High
Opioid 5 92.32 High High
Inflammation 39 91.84 High High
cytokine 96 90.88 High High
Pain 1 77.52 Quite High
opioid receptor 2 76.08 Quite High
Inflammatory response 4 71.84 Quite High
methotrexate 33 37.36 Quite Low
endometriosis 1 34.28 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 463 98.32 Very High Very High Very High
Congenital Anomalies 3 95.44 Very High Very High Very High
INFLAMMATION 53 91.84 High High
Chickenpox 1 89.84 High High
Asthma 6 89.36 High High
Herpes Zoster 7 86.64 High High
Infection 4 84.20 Quite High
Pain 1 77.52 Quite High
Lymphatic System Cancer 1 76.08 Quite High
Aging 8 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, when maximal concentrations of PHA or Con A are employed, leptin has no further effect.
Positive_regulation (concentrations) of PHA
1) Confidence 0.49 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.06 Pain Relevance 0
Within 6 months after PBSCT, all patients showed a decreased in vitro response to mitogens including PHA, Con A and PWM but these responses gradually recovered during the subsequent 6 months.
Positive_regulation (response) of PHA
2) Confidence 0.49 Published 1994 Journal Bone Marrow Transplant. Section Abstract Doc Link 7994235 Disease Relevance 1.06 Pain Relevance 0.08
Furthermore, analysis of mRNA from human peripheral blood lymphocytes demonstrates that activation of the lymphocytes with PHA results in at least a 10-fold induction of the AT7-5EU message.
Positive_regulation (activation) of PHA in lymphocytes
3) Confidence 0.39 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7500847 Disease Relevance 0 Pain Relevance 0.47
The proliferation after 24 h phytohaemagglutinin (PHA) activation was significantly inhibited at high concentrations of salmeterol, isoprenaline and salbutamol (> or = 10(-6) M).
Positive_regulation (activation) of PHA
4) Confidence 0.25 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0.09 Pain Relevance 0.09
A U-shaped concentration response curve was observed for the effect of all agonists on IL-4 production 24 h after PHA activation.
Positive_regulation (activation) of PHA associated with agonist
5) Confidence 0.25 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0.08 Pain Relevance 0.13
A biphasic concentration response curve was observed for the inhibitory activity of all beta-adrenoceptor agonists on IFN-gamma production by PBMC 24 h after PHA activation.
Positive_regulation (activation) of PHA in PBMC associated with agonist
6) Confidence 0.25 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0.06 Pain Relevance 0.16
production of RA-PBMCs in response to IL-12 and IL-18 was lower than that of H-PBMCs, even with the activation of PHA and PMA.
Positive_regulation (activation) of PHA associated with rheumatoid arthritis
7) Confidence 0.16 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.78 Pain Relevance 0.51
However, even with the stimulation of PHA and PMA, the IFN-?
Positive_regulation (stimulation) of PHA
8) Confidence 0.14 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.68 Pain Relevance 0.34
These observations indicate that the stimulation of PHA/PMA induces PBMCs to produce significant amounts of IL-18.
Positive_regulation (stimulation) of PHA
9) Confidence 0.11 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.82 Pain Relevance 0.38
Stimulation with PHA and PMA further augmented the magnitude of IFN-?
Positive_regulation (Stimulation) of PHA
10) Confidence 0.10 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 1.12 Pain Relevance 0.53
Stimulation of THP-1 with PHA was therefore used in the subsequent transfection experiments.
Positive_regulation (Stimulation) of PHA in THP-1
11) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0.40 Pain Relevance 0.17

General Comments

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