INT4811

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Context Info
Confidence 0.65
First Reported 1992
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 3.29
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (LTC4S) nuclear envelope (LTC4S) small molecule metabolic process (LTC4S)
lyase activity (LTC4S) endoplasmic reticulum (LTC4S) nucleus (LTC4S)
Anatomy Link Frequency
mast cells 6
smooth muscle cells 3
HLMC 2
nerve 1
LTC4S (Homo sapiens)
Pain Link Frequency Relevance Heat
Buprenorphine 12 99.88 Very High Very High Very High
Morphine 12 98.72 Very High Very High Very High
Inflammatory marker 3 98.64 Very High Very High Very High
ketamine 4 94.96 High High
Versed 4 85.76 High High
depression 8 83.92 Quite High
Opioid 14 77.48 Quite High
cytokine 4 56.20 Quite High
Inflammation 50 50.00 Quite Low
nud 12 19.24 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 60 98.32 Very High Very High Very High
Rhinitis 16 97.80 Very High Very High Very High
Hypersensitivity 8 96.88 Very High Very High Very High
Malabsorption Syndromes 2 93.68 High High
Pressure And Volume Under Development 4 93.48 High High
Asthma 9 93.00 High High
Eczema 2 92.68 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

154 90.16 High High
Depression 8 83.92 Quite High
Infection 4 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Buprenorphine also induced de novo synthesis of PGD2 and LTC4 from lung mast cells.
Positive_regulation (induced) of Gene_expression (synthesis) of LTC4 in mast cells associated with buprenorphine
1) Confidence 0.65 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1280014 Disease Relevance 0 Pain Relevance 0.97
Fentanyl (10(-5)-10(-3) M) did not induce histamine and tryptase release or the de novo synthesis of PGD2 or LTC4 from any mast cells.
Neg (not) Positive_regulation (induce) of Gene_expression (synthesis) of LTC4 in mast cells
2) Confidence 0.65 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1280014 Disease Relevance 0 Pain Relevance 0.90
In contrast, buprenorphine caused histamine and tryptase release from HLMC, and not from HSMC, whilst it also induced de novo synthesis of PGD2 and LTC4 in HLMC.
Positive_regulation (induced) of Gene_expression (synthesis) of LTC4 in HLMC associated with buprenorphine
3) Confidence 0.63 Published 1993 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 7690200 Disease Relevance 0 Pain Relevance 0.30
The muscle relaxants and hypnotics examined did not induce any de novo synthesis of PGD2 or LTC4 in mast cells.
Neg (not) Spec (examined) Positive_regulation (induce) of Gene_expression (synthesis) of LTC4 in mast cells
4) Confidence 0.42 Published 1993 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 7690200 Disease Relevance 0 Pain Relevance 0.51
While concentrations of LTC4/D4/E4, were significantly higher in CRS-NP compared to CRS and controls, no differences were observed in LTB4 levels between the groups.
Positive_regulation (concentrations) of Gene_expression (/) of LTC4
5) Confidence 0.08 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.37 Pain Relevance 0.10
The degranulation of mast cells leads to the production of local and systemic mediators, such as leucotriens LTC4 and histamine, which act upon adjacent smooth muscle cells and nerve endings.
Positive_regulation (leads) of Gene_expression (production) of LTC4 in smooth muscle cells
6) Confidence 0.01 Published 2010 Journal Gut Pathog Section Body Doc Link PMC2876056 Disease Relevance 0.87 Pain Relevance 0.07
The degranulation of mast cells leads to the production of local and systemic mediators, such as leucotriens LTC4 and histamine, which act upon adjacent smooth muscle cells and nerve endings.
Positive_regulation (leads) of in nerve Gene_expression (production) of LTC4 in smooth muscle cells
7) Confidence 0.00 Published 2010 Journal Gut Pathog Section Body Doc Link PMC2876056 Disease Relevance 0.87 Pain Relevance 0.07

General Comments

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