INT48117

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Context Info
Confidence 0.10
First Reported 1995
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.28

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extracellular region (GH1, CGA) signal transduction (CGA) extracellular space (GH1)
small molecule metabolic process (CGA) cellular nitrogen compound metabolic process (CGA) cell-cell signaling (CGA)
GH1 (Homo sapiens)
CGA (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 18 100.00 Very High Very High Very High
Opioid 9 91.04 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both hGH and naloxone increased the concentrations of human chorionic gonadotropin (hCG) and progesterone in the media.
hGH Positive_regulation (increased) of hCG associated with narcan
1) Confidence 0.10 Published 1995 Journal Gynecol. Endocrinol. Section Abstract Doc Link 7502693 Disease Relevance 0 Pain Relevance 0.38
High naloxone concentrations significantly decreased both hCG and progesterone secretion induced by high doses of hGH.
hGH Positive_regulation (induced) of hCG associated with narcan
2) Confidence 0.07 Published 1995 Journal Gynecol. Endocrinol. Section Abstract Doc Link 7502693 Disease Relevance 0 Pain Relevance 0.45
The concomitant treatment with ineffective doses of naloxone and hGH was able to enhance hCG and progesterone secretion reaching levels similar to those obtained with the highest doses of hGH alone.
hGH Positive_regulation (enhance) of hCG associated with narcan
3) Confidence 0.07 Published 1995 Journal Gynecol. Endocrinol. Section Abstract Doc Link 7502693 Disease Relevance 0 Pain Relevance 0.45

General Comments

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