INT48141

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Context Info
Confidence 0.39
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 9.93
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf3) extracellular region (Csf3) enzyme binding (Csf3)
Anatomy Link Frequency
granulocyte 3
neutrophils 2
macrophage 1
liver 1
bone marrow 1
Csf3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 16 99.56 Very High Very High Very High
Inflammation 14 99.00 Very High Very High Very High
cytokine 13 98.42 Very High Very High Very High
Angina 3 97.20 Very High Very High Very High
Cancer pain 3 96.04 Very High Very High Very High
fibrosis 7 92.36 High High
ketamine 1 85.20 High High
anesthesia 3 80.72 Quite High
Hyperalgesia 1 71.96 Quite High
primary afferent fibers 1 67.28 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 8 100.00 Very High Very High Very High
Syndrome 6 99.98 Very High Very High Very High
Neutropenia 8 99.96 Very High Very High Very High
Body Weight 20 99.12 Very High Very High Very High
Skin Diseases 3 99.08 Very High Very High Very High
INFLAMMATION 15 99.00 Very High Very High Very High
Emphysema 20 98.80 Very High Very High Very High
Cancer 23 98.20 Very High Very High Very High
Leukemia 4 97.80 Very High Very High Very High
Angina 3 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because of the symptoms associated with G-CSF, these individuals must be monitored closely.
G-CSF Binding (associated) of
1) Confidence 0.39 Published 1996 Journal Transfusion Section Body Doc Link 8701455 Disease Relevance 0 Pain Relevance 0
Moreover, G-CSF is a pleiotropic factor that for example also impacts on immunocompetence and inflammatory reactions.
G-CSF Binding (impacts) of associated with inflammation
2) Confidence 0.36 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 1.47 Pain Relevance 0.08
Sweet's syndrome associated with G-CSF.
G-CSF Binding (associated) of associated with syndrome
3) Confidence 0.28 Published 1993 Journal Br. J. Haematol. Section Title Doc Link 7504506 Disease Relevance 0.95 Pain Relevance 0.09
Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy.
G-CSF Binding (association) of in granulocyte associated with neutropenia and skin diseases
4) Confidence 0.26 Published 2001 Journal Pediatr Dermatol Section Title Doc Link 11737689 Disease Relevance 0.81 Pain Relevance 0.19
As with all glyco-protein hormones, G-CSF interacts with target cells by binding to specific cell-surface receptors.
G-CSF Binding (binding) of
5) Confidence 0.26 Published 1993 Journal Acta Haematol Pol Section Abstract Doc Link 7504384 Disease Relevance 0.25 Pain Relevance 0
Radiation-induced liver damage and G-CSF-mobilized CD34+ HSCs administration
G-CSF Binding (Radiation) of in liver associated with hepatotoxicity
6) Confidence 0.20 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2941114 Disease Relevance 0.44 Pain Relevance 0.04
Combination of G-CSF and ATRA had an additive effect, indicating that mobilization of BMCs may play an important role in lung regeneration after injury.
G-CSF Binding (Combination) of in lung associated with injury
7) Confidence 0.17 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695612 Disease Relevance 0.84 Pain Relevance 0
Surprisingly, G-CSF, previously recognized as a late acting lineage-specific factor for neutrophil production, not only disrupts homeostasis between stem cells and their microenvironment, but also induces significant quantitative and qualitative changes in the accessory cell compartment, affecting lymphocytes, monocytes, natural killer, dendritic, and stromal cells.
G-CSF Binding (recognized) of in stem cells
8) Confidence 0.14 Published 2000 Journal Bone Marrow Transplant. Section Abstract Doc Link 10918400 Disease Relevance 0.19 Pain Relevance 0.12
SPR measurements showed that PEGLip bind both recombinant and plasma-derived FVIII45,46 as well as FVIIa.47 PEGLip also bind additional proteins such as recombinant human granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF), and glucagon-like peptide 1 (GLP-1).48 Affinity constants (KD) for all of these interactions were in the low nM range (0.4–12 nM).
G-CSF Binding (interactions) of in macrophage
9) Confidence 0.07 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2939703 Disease Relevance 0 Pain Relevance 0
[Splenic and bone marrow increased 18F-FDG uptake in a PET scan performed following treatment with G-CSF].
G-CSF Binding (treatment) of in bone marrow
10) Confidence 0.05 Published 2004 Journal Rev Esp Med Nucl Section Title Doc Link 15000944 Disease Relevance 0.24 Pain Relevance 0.10
Interruption of G-CSF and GM-CSF signaling in vivo led to reduced tumor growth and nerve remodeling, and abrogated bone cancer pain.
G-CSF Binding (Interruption) of in nerve associated with cancer pain and cancer
11) Confidence 0.04 Published 2009 Journal Nat. Med. Section Abstract Doc Link 19525966 Disease Relevance 1.32 Pain Relevance 0.63
After 5 days, G-CSF (10 ?
G-CSF Binding (After) of
12) Confidence 0.04 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17815 Disease Relevance 0.27 Pain Relevance 0
Furthermore, studies have indicated that there are PD–PK interactions between neutrophils and G-CSF, since neutrophils appear to contribute to G-CSF clearance [14].
G-CSF Binding (interactions) of in neutrophils
13) Confidence 0.04 Published 2010 Journal Ann Hematol Section Body Doc Link PMC2924967 Disease Relevance 0.06 Pain Relevance 0
Recombinant human granulocyte-stimulating factor (rh-GSF)
granulocyte-stimulating factor Binding (Recombinant) of in granulocyte
14) Confidence 0.03 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785861 Disease Relevance 0.64 Pain Relevance 0.03
Blood samples were collected for measurement of plasma G-CSF at ?
G-CSF Binding (measurement) of in Blood
15) Confidence 0.03 Published 2010 Journal Ann Hematol Section Body Doc Link PMC2924967 Disease Relevance 0 Pain Relevance 0
A number of cytokines are used as haemopoietic growth factors and this review focuses on toxicities associated with granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), interleukin (IL)-1, IL-3, IL-4, IL-6 and macrophage colony-stimulating factor (M-CSF).
G-CSF Binding (associated) of in granulocyte associated with cytokine
16) Confidence 0.02 Published 1995 Journal Drug Saf Section Abstract Doc Link 8652081 Disease Relevance 0.33 Pain Relevance 0.16
MDX-447 has been found to be immunologically active at all doses, binding to circulating monocytes and neutrophils (when given with G-CSF), causing monocytopenia and stimulating increases in circulating plasma cytokines.
G-CSF Binding (binding) of in monocytes associated with cytokine
17) Confidence 0.01 Published 1997 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 9435876 Disease Relevance 1.06 Pain Relevance 0.13
MDX-447 has been found to be immunologically active at all doses, binding to circulating monocytes and neutrophils (when given with G-CSF), causing monocytopenia and stimulating increases in circulating plasma cytokines.
G-CSF Binding (binding) of in neutrophils associated with cytokine
18) Confidence 0.00 Published 1997 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 9435876 Disease Relevance 1.06 Pain Relevance 0.13

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