INT48144

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2011
Negated 7
Speculated 4
Reported most in Abstract
Documents 117
Total Number 124
Disease Relevance 43.00
Pain Relevance 20.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgf2) extracellular space (Fgf2) extracellular region (Fgf2)
nucleus (Fgf2) embryo development (Fgf2) cytoplasm (Fgf2)
Anatomy Link Frequency
fibroblast 20
astrocytes 4
nucleus 3
spinal 3
myocardium 3
Fgf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 222 100.00 Very High Very High Very High
Nerve growth factor 355 99.88 Very High Very High Very High
allodynia 6 99.88 Very High Very High Very High
agonist 251 99.84 Very High Very High Very High
Acupuncture 19 99.84 Very High Very High Very High
metalloproteinase 96 99.64 Very High Very High Very High
antidepressant 60 99.54 Very High Very High Very High
fluoxetine 35 99.36 Very High Very High Very High
Pain 70 99.26 Very High Very High Very High
cINOD 13 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 379 100.00 Very High Very High Very High
Apoptosis 167 100.00 Very High Very High Very High
Pituitary Cancer 118 100.00 Very High Very High Very High
Aids-related Complex 50 100.00 Very High Very High Very High
Necrosis 26 100.00 Very High Very High Very High
Neuropathic Pain 40 99.88 Very High Very High Very High
Head Trauma 12 99.84 Very High Very High Very High
Retinal Degeneration 145 99.80 Very High Very High Very High
Hydrocephalus 36 99.80 Very High Very High Very High
Rheumatoid Arthritis 92 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Higher dosage of yohimbine inhibited the baseline expression of bFGF.
Gene_expression (expression) of bFGF
1) Confidence 0.78 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8815881 Disease Relevance 0 Pain Relevance 0.48
These results indicate that regulation of bFGF expression in photoreceptors is unique in the CNS and suggest that endogenous bFGF promotes photoreceptor survival.
Gene_expression (expression) of bFGF in photoreceptors
2) Confidence 0.78 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8815881 Disease Relevance 0 Pain Relevance 0.45
Of particular interest is the finding that the induced bFGF expression occurred almost exclusively in the inner segment region of photoreceptors.
Gene_expression (expression) of bFGF in photoreceptors
3) Confidence 0.78 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8815881 Disease Relevance 0 Pain Relevance 0.48
Moreover, glucocorticoids might also be able to modulate FGF-2 expression in the neuronal fiber surrounding Schwann cells, which may be potentially involved in sprouting and outgrowth of lesioned axons [18].
Gene_expression (expression) of FGF-2 in neuronal
4) Confidence 0.78 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.23 Pain Relevance 0.22
Moreover, dexamethasone, a potent synthetic glucocorticoid agonist, was shown to induce the FGF-2 gene expression in primary culture of rat astrocytes from different CNS regions [86], and also to increase FGF-2 immunoreactivity in the substantia nigra astrocytes [88], further emphasizing the influence of steroid hormones on astroglial FGF-2 mechanisms.
Gene_expression (expression) of FGF-2 in substantia nigra associated with substantia nigra, agonist, central nervous system and dexamethasone
5) Confidence 0.78 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.26 Pain Relevance 0.24
Because the levels of astroglial reaction (seen by the increased number of GFAP immunepositive cells) and the levels of the changes in the astroglial FGF-2 immunoreactivity were higher after facial nerve transection (without fiber regeneration) than after crush (leading to a favorable regeneration), it is possible that such a regenerative failure-impairing the internalization of FGF-2 synthesized in the periphery might have favored FGF-2 synthesis in reactive astrocytes of transected facial nucleus.
Gene_expression (synthesis) of FGF-2 in astrocytes
6) Confidence 0.78 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0 Pain Relevance 0.08
It was reported that the FGF-2 synthesized in the tongue may be retrogradaly transported to the hypoglossal nucleus thus acting as a target derived neurotrophic factor.
Gene_expression (synthesized) of FGF-2 in nucleus
7) Confidence 0.78 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.06 Pain Relevance 0.10
The present study is aimed at establishing whether prolonged antidepressant treatments increase the expression of basic fibroblast growth factor (FGF2), a polypeptide growth factor that has a broad neurotrophic activity in the adult central nervous system.
Gene_expression (expression) of basic fibroblast growth factor in fibroblast associated with antidepressant and central nervous system
8) Confidence 0.78 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11961119 Disease Relevance 0 Pain Relevance 0.47
The present study is aimed at establishing whether prolonged antidepressant treatments increase the expression of basic fibroblast growth factor (FGF2), a polypeptide growth factor that has a broad neurotrophic activity in the adult central nervous system.
Gene_expression (expression) of FGF2 in fibroblast associated with antidepressant and central nervous system
9) Confidence 0.78 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11961119 Disease Relevance 0 Pain Relevance 0.47
Antidepressant treatments induce the expression of basic fibroblast growth factor in cortical and hippocampal neurons.
Gene_expression (expression) of basic fibroblast growth factor in neurons associated with antidepressant
10) Confidence 0.78 Published 2002 Journal Mol. Pharmacol. Section Title Doc Link 11961119 Disease Relevance 0 Pain Relevance 0.54
Administration of 18 microg of anti-FGF-2 antibodies attenuated mechanical allodynia at day 21 after SpNL and reduced FGF-2 and glial acidic fibrillary protein mRNA expression and immunoreactivity in the L5 spinal cord segment of rats with SpNL.
Gene_expression (expression) of FGF-2 in spinal cord segment associated with allodynia and spinal cord
11) Confidence 0.78 Published 2005 Journal J. Mol. Neurosci. Section Abstract Doc Link 16280602 Disease Relevance 0.83 Pain Relevance 0.89
Following inflammation, the area density of GFAP-IR as well as the proportion of astrocytes expressing FGF-2 increased significantly while the degree of astrocyte arborisation decreased as shown by a shape factor.
Gene_expression (expressing) of FGF-2 in astrocytes associated with inflammation
12) Confidence 0.78 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135927 Disease Relevance 0.34 Pain Relevance 0.18
The data indicate that spinal astrocytes may influence pain processes particularly by increased FGF-2 synthesis.
Gene_expression (synthesis) of FGF-2 in spinal associated with pain
13) Confidence 0.78 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135927 Disease Relevance 0.43 Pain Relevance 0.18
After 12 days, the immunoreactivity (IR) for glial fibrillary acidic protein (GFAP), morphometric parameters, and fibroblast growth factor-2 (FGF-2) expression of astrocytes were quantitatively evaluated in the dorsal horn of the spinal segment L4.
Gene_expression (expression) of FGF-2 in spinal associated with dorsal horn
14) Confidence 0.78 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135927 Disease Relevance 0.33 Pain Relevance 0.16
After 12 days, the immunoreactivity (IR) for glial fibrillary acidic protein (GFAP), morphometric parameters, and fibroblast growth factor-2 (FGF-2) expression of astrocytes were quantitatively evaluated in the dorsal horn of the spinal segment L4.
Gene_expression (expression) of fibroblast growth factor-2 in spinal associated with dorsal horn
15) Confidence 0.78 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135927 Disease Relevance 0.33 Pain Relevance 0.16
In this study, we focused on bFGF, which is a well-known mitogen for various types of cells, and is present in the salivary gland as well as in saliva.
Gene_expression (present) of bFGF in saliva
16) Confidence 0.77 Published 2000 Journal Adv. Dent. Res. Section Abstract Doc Link 11842932 Disease Relevance 0.07 Pain Relevance 0
Fluoxetine and olanzapine have synergistic effects in the modulation of fibroblast growth factor 2 expression within the rat brain.
Gene_expression (expression) of fibroblast growth factor 2 in fibroblast associated with fluoxetine
17) Confidence 0.77 Published 2004 Journal Biol. Psychiatry Section Title Doc Link 15158429 Disease Relevance 0.09 Pain Relevance 0.29
METHODS: We investigated the expression of the neurotrophic molecule basic fibroblast growth factor 2 (FGF-2) after acute or chronic administration of FLX and OLA, alone or in combination.
Spec (investigated) Gene_expression (expression) of FGF-2 in fibroblast
18) Confidence 0.77 Published 2004 Journal Biol. Psychiatry Section Body Doc Link 15158429 Disease Relevance 0 Pain Relevance 0
Ribonuclease (RNase) protection assay and Western blot analysis were employed to determine FGF-2 expression in different brain structures and to identify the intracellular pathways possibly involved in FGF-2 modulation.
Spec (determine) Gene_expression (expression) of FGF-2 in brain structures
19) Confidence 0.77 Published 2004 Journal Biol. Psychiatry Section Body Doc Link 15158429 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Based on these data, we hypothesize a role of endogenously synthesized FGF-2 in the effects of FLX/OLA combination on brain function and plasticity, which could contribute to its superior efficacy for the treatment of resistant depression.


Gene_expression (synthesized) of FGF-2 in brain
20) Confidence 0.77 Published 2004 Journal Biol. Psychiatry Section Body Doc Link 15158429 Disease Relevance 0 Pain Relevance 0

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