INT48162

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Context Info
Confidence 0.10
First Reported 1993
Last Reported 1993
Negated 0
Speculated 6
Reported most in Abstract
Documents 1
Total Number 6
Disease Relevance 2.14
Pain Relevance 3.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (LTC4S) nuclear envelope (LTC4S) small molecule metabolic process (LTC4S)
lyase activity (LTC4S) endoplasmic reticulum (LTC4S) nucleus (LTC4S)
Anatomy Link Frequency
mast cells 9
basophils 3
RIMS3 (Homo sapiens)
LTC4S (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 36 98.12 Very High Very High Very High
cINOD 24 96.72 Very High Very High Very High
Inflammation 6 94.44 High High
Kinase C 6 44.48 Quite Low
agonist 6 25.00 Low Low
Disease Link Frequency Relevance Heat
Disease 6 94.80 High High
INFLAMMATION 18 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the effects of NIM and of its in vivo metabolite, 4-hydroxy-NIM (OH-NIM), on the release of performed (histamine) and de novo synthesized mediators (sulfidopeptide leukotriene C4 [LTC4] and prostaglandin D2 [PGD2]) from human basophils and mast cells isolated from lung parenchyma (HLMC) and skin (HSMC).
OH-NIM Spec (investigated) Regulation (effects) of Localization (release) of leukotriene C4 in mast cells
1) Confidence 0.10 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7505332 Disease Relevance 0.36 Pain Relevance 0.54
We investigated the effects of NIM and of its in vivo metabolite, 4-hydroxy-NIM (OH-NIM), on the release of performed (histamine) and de novo synthesized mediators (sulfidopeptide leukotriene C4 [LTC4] and prostaglandin D2 [PGD2]) from human basophils and mast cells isolated from lung parenchyma (HLMC) and skin (HSMC).
NIM Spec (investigated) Regulation (effects) of Localization (release) of leukotriene C4 in mast cells
2) Confidence 0.10 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7505332 Disease Relevance 0.36 Pain Relevance 0.54
We investigated the effects of NIM and of its in vivo metabolite, 4-hydroxy-NIM (OH-NIM), on the release of performed (histamine) and de novo synthesized mediators (sulfidopeptide leukotriene C4 [LTC4] and prostaglandin D2 [PGD2]) from human basophils and mast cells isolated from lung parenchyma (HLMC) and skin (HSMC).
NIM Spec (investigated) Regulation (effects) of Localization (release) of leukotriene C4 in mast cells
3) Confidence 0.10 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7505332 Disease Relevance 0.36 Pain Relevance 0.54
We investigated the effects of NIM and of its in vivo metabolite, 4-hydroxy-NIM (OH-NIM), on the release of performed (histamine) and de novo synthesized mediators (sulfidopeptide leukotriene C4 [LTC4] and prostaglandin D2 [PGD2]) from human basophils and mast cells isolated from lung parenchyma (HLMC) and skin (HSMC).
OH-NIM Spec (investigated) Regulation (effects) of in basophils Localization (release) of leukotriene C4 in mast cells
4) Confidence 0.03 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7505332 Disease Relevance 0.36 Pain Relevance 0.54
We investigated the effects of NIM and of its in vivo metabolite, 4-hydroxy-NIM (OH-NIM), on the release of performed (histamine) and de novo synthesized mediators (sulfidopeptide leukotriene C4 [LTC4] and prostaglandin D2 [PGD2]) from human basophils and mast cells isolated from lung parenchyma (HLMC) and skin (HSMC).
NIM Spec (investigated) Regulation (effects) of in basophils Localization (release) of leukotriene C4 in mast cells
5) Confidence 0.03 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7505332 Disease Relevance 0.36 Pain Relevance 0.54
We investigated the effects of NIM and of its in vivo metabolite, 4-hydroxy-NIM (OH-NIM), on the release of performed (histamine) and de novo synthesized mediators (sulfidopeptide leukotriene C4 [LTC4] and prostaglandin D2 [PGD2]) from human basophils and mast cells isolated from lung parenchyma (HLMC) and skin (HSMC).
NIM Spec (investigated) Regulation (effects) of in basophils Localization (release) of leukotriene C4 in mast cells
6) Confidence 0.03 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7505332 Disease Relevance 0.36 Pain Relevance 0.54

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