INT48164

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Context Info
Confidence 0.55
First Reported 1993
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.22
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (LTC4S) nuclear envelope (LTC4S) small molecule metabolic process (LTC4S)
lyase activity (LTC4S) endoplasmic reticulum (LTC4S) nucleus (LTC4S)
Anatomy Link Frequency
HLMC 4
eosinophils 2
LTC4S (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 12 93.92 High High
agonist 3 88.64 High High
adenocard 2 88.64 High High
Kinase C 2 83.24 Quite High
cINOD 9 75.00 Quite High
Inflammation 2 42.32 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 75.00 Quite High
Disease 2 42.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, at comparable concentrations, only nimesulide was able to inhibit the synthesis of PAF and LTC4 in activated eosinophils.
Negative_regulation (inhibit) of Gene_expression (synthesis) of LTC4 in eosinophils
1) Confidence 0.55 Published 1996 Journal Eur Respir J Suppl Section Abstract Doc Link 8871060 Disease Relevance 0.07 Pain Relevance 0.18
NIM (10(-6) to 10(-3) M) markedly inhibited the de novo synthesis of LTC4 from basophils, LTC4 and PGD2 from HLMC and PGD2 from HSMC.
Negative_regulation (inhibited) of Gene_expression (synthesis) of LTC4 in HLMC
2) Confidence 0.28 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7505332 Disease Relevance 0.07 Pain Relevance 0.28
NIM (10(-6) to 10(-3) M) markedly inhibited the de novo synthesis of LTC4 from basophils, LTC4 and PGD2 from HLMC and PGD2 from HSMC.
Negative_regulation (inhibited) of Gene_expression (synthesis) of LTC4 in HLMC
3) Confidence 0.28 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7505332 Disease Relevance 0.07 Pain Relevance 0.28

General Comments

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