INT48192

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Context Info
Confidence 0.42
First Reported 1993
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 4.41
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Setd1a) nucleus (Setd1a)
Anatomy Link Frequency
brain 4
Notch 1
Fascicles 1
CNS 1
Setd1a (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 1 98.16 Very High Very High Very High
cINOD 1 96.04 Very High Very High Very High
Inflammation 19 95.08 Very High Very High Very High
Central nervous system 20 93.04 High High
Serotonin 1 86.04 High High
Nerve growth factor 64 86.00 High High
antidepressant 3 84.68 Quite High
fluoxetine 1 79.52 Quite High
Potency 8 79.32 Quite High
beta blocker 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 8 99.76 Very High Very High Very High
Brain Tumor 196 99.16 Very High Very High Very High
Cv General 3 Under Development 1 98.16 Very High Very High Very High
Stroke 9 97.80 Very High Very High Very High
Hypertension 2 97.60 Very High Very High Very High
Injury 26 96.64 Very High Very High Very High
INFLAMMATION 20 95.08 Very High Very High Very High
Graft Vs Host Disease 6 93.56 High High
Frailty 4 93.44 High High
Cancer 208 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cell cycle (not viability) is blocked concomitantly with NSC block.
Neg (blocked) Gene_expression (blocked) of NSC
1) Confidence 0.42 Published 1993 Journal EXS Section Abstract Doc Link 7505659 Disease Relevance 0 Pain Relevance 0.10
The pharmacological effects are mediated by the activation of Notch signaling in the NSC, but not by the inhibition of GSK-3b signaling or inositol depletion, currently popular models to explain mood stabilizers' action.
Gene_expression (signaling) of NSC in Notch
2) Confidence 0.29 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 19108505 Disease Relevance 0.57 Pain Relevance 0.27
The current technique includes determination of the source of working stem cells (MSC, NSC, eNSC), the selection of culture media, the state of stem cell cycle (undifferentiated vs. differentiated), the mode of culture (adhere vs. suspension), the form of growth (neurosphere vs. monolayer), substrate variations (Fibronectin, laminin, or Matrigel) and using different animal models to test each therapeutic variation, each possible way of using different stem cells (MSC, NSC, eNSC) to treat different brain cancers.
Gene_expression (source) of NSC in brain associated with brain tumor
3) Confidence 0.01 Published 2008 Journal Cancer Cell Int Section Body Doc Link PMC2474582 Disease Relevance 0.43 Pain Relevance 0.10
The current technique includes determination of the source of working stem cells (MSC, NSC, eNSC), the selection of culture media, the state of stem cell cycle (undifferentiated vs. differentiated), the mode of culture (adhere vs. suspension), the form of growth (neurosphere vs. monolayer), substrate variations (Fibronectin, laminin, or Matrigel) and using different animal models to test each therapeutic variation, each possible way of using different stem cells (MSC, NSC, eNSC) to treat different brain cancers.
Gene_expression (source) of eNSC in brain associated with brain tumor
4) Confidence 0.01 Published 2008 Journal Cancer Cell Int Section Body Doc Link PMC2474582 Disease Relevance 0.43 Pain Relevance 0.10
Fascicles of various sizes and disorganized nerve fibers were noted to develop in rabbits having implant of HA-collagen scaffold, NSC and HA-collagen scaffold, and NT-3-supplemented HA-collagen composite scaffold (Figure 3B).
Gene_expression (scaffold) of NSC in Fascicles
5) Confidence 0.01 Published 2008 Journal J Transl Med Section Body Doc Link PMC2614414 Disease Relevance 0.26 Pain Relevance 0.07
Current thresholds derived from rabbits implanted with HA-collagen scaffold (n = 7), NSC and HA-collagen scaffold (n = 8), and NT-3-supplemented HA-collagen scaffold (n = 6) over 12 weeks were comparable.
Gene_expression (scaffold) of NSC
6) Confidence 0.01 Published 2008 Journal J Transl Med Section Body Doc Link PMC2614414 Disease Relevance 0.18 Pain Relevance 0
In vitro cultures have been used to demonstrate that NSC, neurons and glias express both class I and II MHCs, which were recently recognized to be crucial in the activity-dependent refinement and plasticity of neural connections in the developing and adult CNS [5].
Gene_expression (express) of NSC in CNS associated with central nervous system
7) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936305 Disease Relevance 0.37 Pain Relevance 0.28
The current technique includes determination of the source of working stem cells (MSC, NSC, eNSC), the selection of culture media, the state of stem cell cycle (undifferentiated vs. differentiated), the mode of culture (adhere vs. suspension), the form of growth (neurosphere vs. monolayer), substrate variations (Fibronectin, laminin, or Matrigel) and using different animal models to test each therapeutic variation, each possible way of using different stem cells (MSC, NSC, eNSC) to treat different brain cancers.
Spec (determination) Gene_expression (source) of NSC in brain associated with brain tumor
8) Confidence 0.01 Published 2008 Journal Cancer Cell Int Section Body Doc Link PMC2474582 Disease Relevance 0.50 Pain Relevance 0.10
The current technique includes determination of the source of working stem cells (MSC, NSC, eNSC), the selection of culture media, the state of stem cell cycle (undifferentiated vs. differentiated), the mode of culture (adhere vs. suspension), the form of growth (neurosphere vs. monolayer), substrate variations (Fibronectin, laminin, or Matrigel) and using different animal models to test each therapeutic variation, each possible way of using different stem cells (MSC, NSC, eNSC) to treat different brain cancers.
Spec (determination) Gene_expression (source) of eNSC in brain associated with brain tumor
9) Confidence 0.01 Published 2008 Journal Cancer Cell Int Section Body Doc Link PMC2474582 Disease Relevance 0.50 Pain Relevance 0.10
Of the 107 patients, 84 had angiographically established coronary atherosclerosis (>or=1 lesion with >or=50% narrowing, CAD+), and 23 had no major lesion (CAD-); 67 were taking ss1-selective BB (metoprolol or atenolol) for treatment of angina and/or hypertension and 40 were not.
Neg (no) Gene_expression (taking) of ss1-selective associated with angina, coronary artery disease and hypertension
10) Confidence 0.00 Published 2002 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 12090905 Disease Relevance 1.17 Pain Relevance 0.14

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