INT48199

Context Info Confidence 0.54 First Reported 1993 Last Reported 2010 Negated 6 Speculated 3 Reported most in Body Documents 17 Total Number 20 Disease Relevance 9.57 Pain Relevance 2.74

enzyme binding (Tgfb1) cytoplasm (Tgfb1) cell proliferation (Tgfb1) extracellular space (Tgfb1) extracellular region (Tgfb1) cell death (Tgfb1)

Anatomy Link Frequency plasma 1 embryos 1 neurons 1 osteoclast 1 MDA-MB-231 1 Tgfb1 (Mus musculus)

Pain Link Frequency Relevance Heat gABA 36 100.00 spinal inflammation 2 99.24 Neuritis 6 98.52 fibrosis 105 97.96 Inflammation 131 97.60 Pain 9 93.44 cytokine 34 92.92 medulla 60 91.44 Spinal cord 9 87.36 Action potential 28 76.60

Disease Link Frequency Relevance Heat Cancer 261 100.00 Necrosis 4 100.00 Breast Cancer 80 99.78 Hypoxia 154 99.62 Camurati-engelmann Disease 8 99.48 Low Back Pain 2 99.24 Apoptosis 214 98.72 Experimental Autoimmune Neuritis 6 98.52 Fibrosis 53 97.96 INFLAMMATION 139 97.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results support an essential role of angiotensin II in TGF regulation mediated through the angiotensin II type 1A receptor.

Regulation (regulation) of TGF

1) Confidence 0.54 Published 1999 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 10589702 Disease Relevance 0.67 Pain Relevance 0.17

A mutation affecting the latency-associated peptide of TGFbeta1 in Camurati-Engelmann disease enhances osteoclast formation in vitro.

Regulation (affecting) of TGFbeta1 in osteoclast associated with camurati-engelmann disease

2) Confidence 0.42 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 12843182 Disease Relevance 0.84 Pain Relevance 0.09

Our data indicate that TGF-beta 1 and -beta 3 are involved in regulating the glial response in EAN and that activated microglial cells might control their own activity state by expressing TGF-beta 1.

Regulation (involved) of TGF-beta 1 in microglial cells associated with neuritis

3) Confidence 0.33 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 7505838 Disease Relevance 0.59 Pain Relevance 0.59

In humans, some clinical reports have shown changes in the plasma concentrations of TGF-?

Regulation (changes) of TGF in plasma

4) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2955039 Disease Relevance 1.01 Pain Relevance 0.50

Similarly, no effect of cilomilast treatment on TGF-?

Neg (no) Regulation (effect) of TGF

5) Confidence 0.15 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.99 Pain Relevance 0.46

Similarly to collagen, cilomilast had no significant effect on mRNA level of TGF-?

Neg (no) Regulation (effect) of TGF

6) Confidence 0.10 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.44 Pain Relevance 0.22

Altogether, after analyzing the morphology and function of the NMJ, we found no alteration in embryonic TGF-?

Neg (no) Regulation (alteration) of TGF

7) Confidence 0.08 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.17

2 KO embryos revealed no difference in its overall structure (as illustrated by Nissl-staining) and also the fiber connections, as illustrated with anti-neurofilament 150 kDa antibody, did not show alterations in the TGF-?

Neg (not) Regulation (alterations) of TGF in embryos

8) Confidence 0.08 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.05

, demonstrating that hypoxia does not directly regulate TGF-?

Neg (not) Regulation (regulate) of TGF associated with hypoxia

9) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.48 Pain Relevance 0

One possible explanation for the extensive reduction of the frequencies of glutamatergic or GABA/glycinergic miniature events in TGF-?

Spec (possible) Regulation (explanation) of TGF associated with gaba

10) Confidence 0.07 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.17

Ultra-structural analysis of synapses of preBötC neurons reveals no changes in TGF-?

Neg (no) Regulation (changes) of TGF in neurons

11) Confidence 0.07 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.04

In VSMCs, incubation with L-mevalonate significantly decreased the effect of statins on TGF-?

Regulation (effect) of TGF

12) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.60 Pain Relevance 0

In this study we explore how these cellular action regulate TGF-?

Regulation (regulate) of TGF

13) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.43 Pain Relevance 0

To determine the role of the TGF-beta1 regulatory pathway in mediating the effects of dexamethasone, neutralizing anti-TGF-beta antibodies were used.

Spec (determine) Regulation (role) of TGF-beta1

14) Confidence 0.04 Published 1999 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10233182 Disease Relevance 0.25 Pain Relevance 0

signaling pathways in vitro by examining bone-metastatic MDA-MB-231 breast cancer cells for changes in TGF-?

Regulation (changes) of TGF in MDA-MB-231 associated with breast cancer

15) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.52 Pain Relevance 0

The loss of this protective effect, attributed to changes in TGF-?

Regulation (changes) of TGF

16) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.70 Pain Relevance 0.09

We further investigated the effect of statins on TGF-?

Spec (investigated) Regulation (effect) of TGF

17) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.11 Pain Relevance 0

Modulation of the TGF- ?

Regulation (Modulation) of TGF

18) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.43 Pain Relevance 0

[Effects of bushen tongdu decoction on serum tumor necrosis factor-alpha and transforming growth factor beta1, in patients with ankylosing spondylitis].

Regulation (Effects) of transforming growth factor beta1 associated with spinal inflammation, necrosis and cancer

19) Confidence 0.02 Published 2008 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Title Doc Link 19317165 Disease Relevance 0.49 Pain Relevance 0.19

METHOD: The effects of TGF-beta1 and/or IGF-1 delivery on osteochondral repair in adult rabbits were examined through histomorphometric analysis of 11 markers of osteochondral repair.

Regulation (effects) of TGF-beta1

20) Confidence 0.01 Published 2007 Journal Osteoarthr. Cartil. Section Body Doc Link 16965923 Disease Relevance 0 Pain Relevance 0

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