INT482

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Context Info
Confidence 0.38
First Reported 1979
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ip6k2) kinase activity (Ip6k2)
Anatomy Link Frequency
nerve 1
heart 1
Ip6k2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 7 99.98 Very High Very High Very High
antagonist 6 99.56 Very High Very High Very High
noradrenaline 6 95.00 High High
cocaine 3 91.84 High High
Clonidine 2 88.04 High High
Catecholamine 3 83.48 Quite High
anesthesia 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Initial rates of extraneuronal uptake were measured after perfusion lasting for 2 min, either in the absence or in the presence of 100 mumol/l O-methyl-isoprenaline, a potent inhibitor of uptake2.
Negative_regulation (inhibitor) of uptake2
1) Confidence 0.38 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6527704 Disease Relevance 0 Pain Relevance 0.08
The present experiments clearly demonstrated that the tested alpha 1-antagonists and alpha 2-agonists inhibited uptake2 in rat heart but the tested alpha 1-agonists and an alpha 2-antagonist did not inhibit it.
Negative_regulation (inhibited) of uptake2 in heart associated with antagonist and agonist
2) Confidence 0.01 Published 1989 Journal Life Sci. Section Abstract Doc Link 2564613 Disease Relevance 0 Pain Relevance 0.57
Uptake2 inhibition by metanephrine (40 micrograms kg-1 min-1) enhanced cardiac responses to isoprenaline (0.05 to 1.0 microgram kg-1 i.v.), but did not significantly alter those to noradrenaline or nerve stimulation.
Negative_regulation (inhibition) of Uptake2 in nerve associated with noradrenaline
3) Confidence 0.00 Published 1979 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 41908 Disease Relevance 0 Pain Relevance 0.41

General Comments

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