INT48200

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 3.85
Pain Relevance 5.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Tgfb1) cytoplasm (Tgfb1) cell proliferation (Tgfb1)
extracellular space (Tgfb1) extracellular region (Tgfb1) cell death (Tgfb1)
Anatomy Link Frequency
liver 4
spinal cord 1
spleen 1
Tgfb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 10 99.84 Very High Very High Very High
Spinal cord 6 99.72 Very High Very High Very High
MU agonist 2 99.44 Very High Very High Very High
Paracetamol 5 99.32 Very High Very High Very High
lidocaine 102 99.18 Very High Very High Very High
Enkephalin 3 98.52 Very High Very High Very High
Opioid 4 96.96 Very High Very High Very High
Neuritis 6 95.00 High High
Endogenous opioid 2 94.92 High High
chemokine 27 94.00 High High
Disease Link Frequency Relevance Heat
Pancreatitis 10 99.84 Very High Very High Very High
Starvation 2 99.74 Very High Very High Very High
Cirrhosis 8 98.32 Very High Very High Very High
Experimental Autoimmune Neuritis 6 95.00 High High
INFLAMMATION 124 90.88 High High
Autoimmune Disease 1 88.16 High High
Neuropathic Pain 1 86.56 High High
Hypoxia 77 84.36 Quite High
Nociception 1 80.88 Quite High
Pain 7 76.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of liver-associated transforming growth factor beta 1 (TGF-beta 1) mRNA expression by carbon tetrachloride leads to the inhibition of T helper 2 cell-associated lymphokines.
Transcription (expression) of transforming growth factor beta 1 in liver
1) Confidence 0.69 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.07
Acute treatment of B6C3F1 mice with a hepatotoxic dose (500 mg/kg) of carbon tetrachloride (CCl4) produced a marked but transient increase in transforming growth factor beta 1 (TGF-beta 1) mRNA expression in the liver within 24 hr.
Transcription (expression) of transforming growth factor beta 1 in liver
2) Confidence 0.69 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.07
Induction of liver-associated transforming growth factor beta 1 (TGF-beta 1) mRNA expression by carbon tetrachloride leads to the inhibition of T helper 2 cell-associated lymphokines.
Transcription (expression) of TGF-beta 1 in liver
3) Confidence 0.69 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.07
Acute treatment of B6C3F1 mice with a hepatotoxic dose (500 mg/kg) of carbon tetrachloride (CCl4) produced a marked but transient increase in transforming growth factor beta 1 (TGF-beta 1) mRNA expression in the liver within 24 hr.
Transcription (expression) of TGF-beta 1 in liver
4) Confidence 0.60 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.07
Transcript levels of TGF-betas and their intracellular effectors correlated directly with genes encoding opioid peptides, whereas BAMBI correlated inversely.
Transcription (levels) of TGF-beta associated with opioid
5) Confidence 0.52 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20107078 Disease Relevance 0.47 Pain Relevance 0.97
No increase in TGF-beta 1 mRNA expression was detected in the spleen following treatment with either agent.
Transcription (expression) of TGF-beta 1 in spleen
6) Confidence 0.51 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.10
TGFb levels in CP patients were higher than those in LC patients, levels being raised in 6/23 patients.
Transcription (levels) of TGFb associated with cirrhosis and chronic pancreatitis
7) Confidence 0.41 Published 1998 Journal J Med Section Abstract Doc Link 10503164 Disease Relevance 1.68 Pain Relevance 0.89
In normal spinal cord tissue, both TGF-beta 1 and TGF-beta 3 mRNA were constitutively expressed at low levels.
Transcription (expressed) of TGF-beta 1 in spinal cord associated with spinal cord
8) Confidence 0.39 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 7505838 Disease Relevance 0.86 Pain Relevance 0.80
After 4 h serum starvation, cells were treated ± TGF-?
Transcription (treated) of TGF associated with starvation
9) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.18 Pain Relevance 0
There were no significant differences between the groups in levels of mRNA for IL-2, IL-8, TNFalpha, or TGFbeta1.
Transcription (levels) of TGFbeta1
10) Confidence 0.11 Published 2006 Journal Arthritis Rheum. Section Body Doc Link 16871547 Disease Relevance 0.06 Pain Relevance 0
In the absence of exogenous TGF-?
Neg (absence) Transcription (absence) of TGF
11) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.11 Pain Relevance 0
We also found that lidocaine (0.08%) significantly decreased exudate levels of TGF-?
Transcription (levels) of TGF associated with lidocaine
12) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.49 Pain Relevance 1.41
We found that D-ala(2),N-Me-Phe(4)-Gly-ol(5)enkephalin (DAMGO), a highly selective mu-opioid agonist, induced the expression of TGF-beta1 expression at the protein and mRNA levels.
Transcription (levels) of TGF-beta1 associated with mu agonist and enkephalin
13) Confidence 0.00 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18252865 Disease Relevance 0 Pain Relevance 0.78

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