INT48201

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 13.65
Pain Relevance 5.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Tgfb1) cytoplasm (Tgfb1) cell proliferation (Tgfb1)
extracellular space (Tgfb1) extracellular region (Tgfb1) cell death (Tgfb1)
Anatomy Link Frequency
muscle 2
spinal cord 2
T cells 2
embryos 1
plasma 1
Tgfb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 90 100.00 Very High Very High Very High
cytokine 70 100.00 Very High Very High Very High
metalloproteinase 39 100.00 Very High Very High Very High
Inflammatory response 16 100.00 Very High Very High Very High
Spinal cord 15 100.00 Very High Very High Very High
Inflammatory mediators 7 100.00 Very High Very High Very High
Chronic pancreatitis 12 98.84 Very High Very High Very High
fibrosis 15 96.20 Very High Very High Very High
Neurotransmitter 20 94.96 High High
Paracetamol 2 93.48 High High
Disease Link Frequency Relevance Heat
Hypoxia 154 100.00 Very High Very High Very High
INFLAMMATION 114 100.00 Very High Very High Very High
Pancreatitis 23 99.92 Very High Very High Very High
Metastasis 212 99.64 Very High Very High Very High
Congenital Anomalies 5 99.22 Very High Very High Very High
Lung Injury 1 99.20 Very High Very High Very High
Apoptosis 90 98.66 Very High Very High Very High
Immunization 21 97.60 Very High Very High Very High
Syndrome 77 96.88 Very High Very High Very High
Fibrosis 17 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization for TGF-beta 1 performed on spinal cord sections 6 days after injection of cells localized TGF-beta 1 mRNA to many nonneuronal cells with the typical morphology of microglia.
Localization (localized) of TGF-beta 1 mRNA in spinal cord associated with spinal cord
1) Confidence 0.59 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 7505838 Disease Relevance 0.74 Pain Relevance 0.77
In situ hybridization for TGF-beta 1 performed on spinal cord sections 6 days after injection of cells localized TGF-beta 1 mRNA to many nonneuronal cells with the typical morphology of microglia.
Localization (localized) of TGF-beta 1 in spinal cord associated with spinal cord
2) Confidence 0.52 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 7505838 Disease Relevance 0.76 Pain Relevance 0.79
Controlled presentation of TGF-beta1 is achieved by either direct perfusion or in situ controlled release from gelatin microspheres immobilized in the 3D-microFCCS.
Localization (presentation) of TGF-beta1
3) Confidence 0.48 Published 2009 Journal Biomaterials Section Abstract Doc Link 19394078 Disease Relevance 0.07 Pain Relevance 0.07
Primary hepatocytes cultured for 7 days with the in situ controlled released TGF-beta1 exhibited up to four-fold higher albumin secretion and two-fold higher phase I/II enzymatic activities, significantly improving the sensitivity of hepatocytes to acetaminophen-mediated hepatotoxicity, compared to hepatocytes cultured with directly perfused TGF-beta1 or without TGF-beta1.
Localization (released) of TGF-beta1 in hepatocytes associated with paracetamol and hepatotoxicity
4) Confidence 0.45 Published 2009 Journal Biomaterials Section Abstract Doc Link 19394078 Disease Relevance 0.09 Pain Relevance 0.09
Relying on the precise pathogenic effect that TGF-?
Localization (effect) of TGF
5) Confidence 0.37 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 0.98 Pain Relevance 0.14
The sections done with EXACT Grunding system and from paraffin blocks were stained with haematoxylin/eosin and by use of biotin-streptavidin immunohistochemistry for transforming growth factor beta1 (TGFbeta1), fibroblast growth factor receptor 1 (FGFR1), interleukin 10 (IL10).
Localization (immunohistochemistry) of TGFbeta1 in fibroblast
6) Confidence 0.21 Published 2009 Journal Stomatologija Section Body Doc Link 20179398 Disease Relevance 0 Pain Relevance 0
Interleukin (IL)-10, a potent anti-inflammatory cytokine, limits the severity of acute pancreatitis and downregulates transforming growth factor (TGF)-beta release by inflammatory cells on stimulation.
Localization (release) of TGF associated with inflammation, pancreatitis and cytokine
7) Confidence 0.17 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12016137 Disease Relevance 0.80 Pain Relevance 0.30
TGF-beta(1) release was measured on plasma, and its pancreatic expression was assessed by quantitative RT-PCR and immunohistochemistry.
Localization (release) of TGF in plasma
8) Confidence 0.17 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12016137 Disease Relevance 1.04 Pain Relevance 0.30
Heroin and M also had a highly stimulatory effect on the release of anti-inflammatory cytokines such as TGF-beta1 and IL-10, though this effect was observed after 120 min, peaking at 24 h and then somewhat decreasing at 48 h.
Localization (release) of TGF-beta1 associated with inflammation and cytokine
9) Confidence 0.15 Published 2000 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 10988355 Disease Relevance 0.39 Pain Relevance 0.67
and PGE2), while cells of the adaptive immune system display counter-inflammatory responses such as IL-10 and TGF?
Localization (responses) of TGF in immune system associated with inflammatory response
10) Confidence 0.15 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2889944 Disease Relevance 1.68 Pain Relevance 0.33
Mechanism of TGF-?
Localization (Mechanism) of TGF
11) Confidence 0.14 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.04
2 KO embryos, although it should be kept in mind that despite their similar expression pattern at the NMJ, wit is a BMP type II receptor orthologue and gbb also represents a BMP orthologue rather than a TGF-?
Localization (represents) of TGF in embryos
12) Confidence 0.14 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0.13 Pain Relevance 0.07
In order to investigate whether neuromuscular synaptic dysfunction contributed to the observed lack of breathing, we studied synaptic transmission at NMJs of dissected diaphragm muscles of three TGF-?
Localization (muscles) of TGF in muscles
13) Confidence 0.14 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0
Moreover, the analysis of miniature events and hypertonic sucrose stimulation pointed to a presynaptically localized defect in TGF-?
Localization (localized) of TGF
14) Confidence 0.14 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.05
MDA-MB-231 cells did not show significant additive responses to TGF-?
Localization (responses) of TGF in MDA-MB-231
15) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.89 Pain Relevance 0
Therefore, we used a mouse model of bone metastasis to assess global crosstalk between the hypoxia and TGF-?
Localization (crosstalk) of TGF associated with hypoxia and metastasis
16) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.54 Pain Relevance 0
The reduction of NMJs could be related to a synapse-independent malformation of the diaphragm muscle, which can be observed in TGF-?
Localization (observed) of TGF in muscle associated with congenital anomalies
17) Confidence 0.12 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0.10 Pain Relevance 0.11
RESULTS: Exposure to ionizing radiation results in a dose-dependent release of TGF alpha.
Localization (release) of TGF
18) Confidence 0.11 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15355899 Disease Relevance 0.08 Pain Relevance 0
Ionizing irradiation also results in the release of TGF alpha for patients undergoing radiation therapy for hormone-refractory prostate cancer.
Localization (release) of TGF
19) Confidence 0.11 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15355899 Disease Relevance 0.06 Pain Relevance 0
During this period, additional irradiation fails to induce XRCC1, ERCC1, or additional TGF alpha release.


Localization (release) of TGF
20) Confidence 0.11 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15355899 Disease Relevance 0 Pain Relevance 0

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