INT48202

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 2
Speculated 7
Reported most in Abstract
Documents 146
Total Number 153
Disease Relevance 89.93
Pain Relevance 27.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Tgfb1) cytoplasm (Tgfb1) cell proliferation (Tgfb1)
extracellular space (Tgfb1) extracellular region (Tgfb1) cell death (Tgfb1)
Anatomy Link Frequency
T cells 10
liver 4
pancreas 3
macrophages 2
ductules 2
Tgfb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 690 100.00 Very High Very High Very High
cytokine 579 100.00 Very High Very High Very High
chemokine 156 100.00 Very High Very High Very High
Chronic pancreatitis 113 100.00 Very High Very High Very High
Enkephalin 11 100.00 Very High Very High Very High
Inflammatory mediators 4 100.00 Very High Very High Very High
Spinal cord 22 99.72 Very High Very High Very High
MU agonist 6 99.72 Very High Very High Very High
Morphine 11 99.50 Very High Very High Very High
fibrosis 257 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 2202 100.00 Very High Very High Very High
Hypoxia 1079 100.00 Very High Very High Very High
INFLAMMATION 741 100.00 Very High Very High Very High
Pancreatitis 124 100.00 Very High Very High Very High
Asthma 68 100.00 Very High Very High Very High
Necrosis 31 100.00 Very High Very High Very High
Parkinson's Disease 31 100.00 Very High Very High Very High
Renal Cancer 48 99.98 Very High Very High Very High
Metastasis 1621 99.88 Very High Very High Very High
Targeted Disruption 167 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes.
Gene_expression (overexpression) of TGF-beta 1 in pancreas associated with diabetes mellitus and chronic pancreatitis
1) Confidence 0.78 Published 1995 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 8554587 Disease Relevance 0.55 Pain Relevance 0.14
We have generated transgenic mice overexpressing TGF-beta 1 in pancreatic beta cells.
Gene_expression (overexpressing) of TGF-beta 1 in pancreatic beta cells associated with targeted disruption
2) Confidence 0.78 Published 1995 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8554587 Disease Relevance 0.51 Pain Relevance 0.12
Here, we show that overexpression of TGFbeta1, by recombinant adenovirus TGFbeta1 gene transfer, in the mesostriatal system of an MPTP mouse model of PD decreased the number of mesencephalic dopaminergic neurons.
Gene_expression (overexpression) of TGFbeta1 in dopaminergic neurons associated with parkinson's disease and disease
3) Confidence 0.78 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 12932441 Disease Relevance 0.79 Pain Relevance 0.21
Here, we show that overexpression of TGFbeta1, by recombinant adenovirus TGFbeta1 gene transfer, in the mesostriatal system of an MPTP mouse model of PD decreased the number of mesencephalic dopaminergic neurons.
Gene_expression (transfer) of TGFbeta1 in dopaminergic neurons associated with parkinson's disease and disease
4) Confidence 0.78 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 12932441 Disease Relevance 0.78 Pain Relevance 0.22
Transforming growth factor beta1 overexpression in the nigrostriatal system increases the dopaminergic deficit of MPTP mice.
Gene_expression (overexpression) of Transforming growth factor beta1 associated with parkinson's disease and enkephalin
5) Confidence 0.78 Published 2003 Journal Mol. Cell. Neurosci. Section Title Doc Link 12932441 Disease Relevance 0.78 Pain Relevance 0.30
Involvement of acute phase Th2 cytokine production and prolonged TGFbeta1 production contribute to intestinal hyper-kinesis in post nematode infectious rat model.
Gene_expression (production) of TGFbeta1 associated with cytokine
6) Confidence 0.78 Published 2006 Journal Nippon Rinsho Section Abstract Doc Link 16898608 Disease Relevance 0.52 Pain Relevance 0.39
Expression of transforming growth factor-beta 1 in chronic pancreatitis.
Gene_expression (Expression) of transforming growth factor-beta 1 associated with chronic pancreatitis
7) Confidence 0.78 Published 1995 Journal Digestion Section Title Doc Link 7657050 Disease Relevance 0.39 Pain Relevance 0.38
In comparison with Snus-treated mice, TS-Elastase-IL-1beta mice had an earlier onset and a greater extent of phenotypic changes, which were associated with up-regulation of TNF-alpha and increased expression of IL-6, TGF-beta, and SDF-1.
Gene_expression (expression) of TGF-beta
8) Confidence 0.75 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20065943 Disease Relevance 1.13 Pain Relevance 0.39
Synthesis of TGF-beta 1 appears to be normally restricted to a population of epithelial cells located in terminal/centroacinar regions of the ductules (together with occasional ductal cells) whereas in chronic pancreatitis, TGF-beta 1 is expressed in most ductular and ductal epithelial cells.
Gene_expression (Synthesis) of TGF-beta 1 in ductules associated with chronic pancreatitis
9) Confidence 0.75 Published 1995 Journal Digestion Section Abstract Doc Link 7657050 Disease Relevance 0.50 Pain Relevance 0.43
Synthesis of TGF-beta 1 appears to be normally restricted to a population of epithelial cells located in terminal/centroacinar regions of the ductules (together with occasional ductal cells) whereas in chronic pancreatitis, TGF-beta 1 is expressed in most ductular and ductal epithelial cells.
Gene_expression (expressed) of TGF-beta 1 in ductules associated with chronic pancreatitis
10) Confidence 0.75 Published 1995 Journal Digestion Section Abstract Doc Link 7657050 Disease Relevance 0.47 Pain Relevance 0.38
None of the well-defined asthma/inflammatory genes (Il1b, Il4, Il10, Il13, Il6, Tnfa, Infg, Tgfb1) are differentially expressed, although they connect many of the genes that are.
Gene_expression (expressed) of Tgfb1 associated with asthma and inflammation
11) Confidence 0.69 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.26 Pain Relevance 0.34
The pancreas morphology of transgenic mice that overexpress transforming growth factor-beta1 (TGF-beta1) in the pancreas resembles partially morphological features of chronic pancreatitis, such as progressive accumulation of extracellular matrix (ECM).
Gene_expression (overexpress) of transforming growth factor-beta1 in pancreas associated with targeted disruption and chronic pancreatitis
12) Confidence 0.68 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11123210 Disease Relevance 0.59 Pain Relevance 0.17
The pancreas morphology of transgenic mice that overexpress transforming growth factor-beta1 (TGF-beta1) in the pancreas resembles partially morphological features of chronic pancreatitis, such as progressive accumulation of extracellular matrix (ECM).
Gene_expression (overexpress) of TGF-beta1 in pancreas associated with targeted disruption and chronic pancreatitis
13) Confidence 0.68 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11123210 Disease Relevance 0.59 Pain Relevance 0.18
We have previously shown that an identical dose of CCl4 also produces a marked increase in serum TGF-beta 1 concentrations which peak at 48 hr and produce a marked inhibition of the anti-sRBC IgM antibody forming cell (AFC) response.
Gene_expression (produce) of TGF-beta 1
14) Confidence 0.65 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.08
No increase in TGF-beta 1 mRNA expression was detected in the spleen following treatment with either agent.
Gene_expression (expression) of TGF-beta 1 in spleen
15) Confidence 0.65 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.10
Sclerosing encapsulating peritonitis (SEP) is a serious complication of long-term continuous ambulatory peritoneal dialysis (CAPD), very likely related to a persisting expression of the transforming growth factor beta1 (TGFbeta1) gene on peritoneal mesothelial cells.
Gene_expression (expression) of TGFbeta1 in mesothelial cells associated with renal failure and peritonitis
16) Confidence 0.64 Published 1999 Journal J. Nephrol. Section Abstract Doc Link 10626830 Disease Relevance 1.35 Pain Relevance 0.07
RESULTS: The TGF-beta1 level in PPP was 2.62*+/- 0.23 (mean +/- SE) ng/mL in migraine, 2.08 +/- 0.20 ng/mL in tension-type headache, and 1.80 +/- 0.09 ng/mL in controls (P= .007, ANOVA; *P < .01, post hoc tests vs. the controls).
Gene_expression (level) of TGF-beta1 in PPP
17) Confidence 0.63 Published 2005 Journal Headache Section Body Doc Link 16178953 Disease Relevance 0.16 Pain Relevance 0
CED is caused by various missense mutations in the TGFB1 gene that encodes TGFbeta1, the most common of which is an arginine-cysteine amino acid change at codon 218 (R218C) in the latency-associated peptide domain of TGFbeta1.
Gene_expression (encodes) of TGFbeta1 associated with camurati-engelmann disease
18) Confidence 0.62 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12843182 Disease Relevance 0.75 Pain Relevance 0.09
Four days after antisense plasmid DNA injection (age of 26 days), messenger RNA expression for TGF-beta 1 was 77 percent lower than in the control group.
Gene_expression (expression) of TGF-beta 1
19) Confidence 0.62 Published 2001 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 11547147 Disease Relevance 0 Pain Relevance 0.06
Modulation TGF-beta 1 gene expression in vivo can alter the natural history of cranial suture fusion.
Gene_expression (expression) of TGF-beta 1 gene in cranial suture
20) Confidence 0.62 Published 2001 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 11547147 Disease Relevance 0 Pain Relevance 0

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