INT48203

Context Info Confidence 0.70 First Reported 1993 Last Reported 2011 Negated 1 Speculated 1 Reported most in Abstract Documents 67 Total Number 68 Disease Relevance 41.31 Pain Relevance 11.07

enzyme binding (Tgfb1) cytoplasm (Tgfb1) cell proliferation (Tgfb1) extracellular space (Tgfb1) extracellular region (Tgfb1) cell death (Tgfb1)

Anatomy Link Frequency striatum 2 respiratory 2 liver 2 T-cell 2 macrophage 1 Tgfb1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 173 100.00 Migraine 5 99.84 rheumatoid arthritis 94 99.72 opioid receptor 1 99.58 medulla 75 99.46 fibrosis 234 98.64 Chronic pancreatitis 34 97.96 Inflammation 360 97.92 Pain 23 97.64 central sensitization 1 97.52

Disease Link Frequency Relevance Heat Death 348 100.00 Apoptosis 1045 99.90 Migraine Disorders 5 99.84 Injury 59 99.82 Osteosclerosis 13 99.82 Rheumatoid Arthritis 94 99.72 Renal Cancer 48 99.70 Targeted Disruption 146 99.64 Sprains And Strains 27 99.60 Hypoxia 314 99.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Transforming growth factor beta1 (TGFbeta1) is increased in the striatum of patients with PD.

Positive_regulation (increased) of TGFbeta1 in striatum associated with disease

1) Confidence 0.70 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 12932441 Disease Relevance 0.77 Pain Relevance 0.20

These results show that an increase in TGFbeta1 levels aggravate the parkinsonian status of MPTP mice and may therefore be a risk factor for the development of PD.

Positive_regulation (increase) of TGFbeta1 associated with parkinson's disease and disease

2) Confidence 0.70 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 12932441 Disease Relevance 0.97 Pain Relevance 0.20

Transforming growth factor beta1 (TGFbeta1) is increased in the striatum of patients with PD.

Positive_regulation (increased) of Transforming growth factor beta1 in striatum associated with disease

3) Confidence 0.70 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 12932441 Disease Relevance 0.78 Pain Relevance 0.20

Similar increases in TGF-beta 1 transcripts scripts in the liver were also induced by an acute hepatotoxic dose (600 mg/kg) of acetaminophen.

Positive_regulation (increases) of TGF-beta 1 in liver associated with paracetamol

4) Confidence 0.67 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.10

We concluded that the R218C mutation increases TGFbeta1 bioactivity and enhances osteoclast formation in vitro.

Positive_regulation (increases) of TGFbeta1 in osteoclast

5) Confidence 0.64 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12843182 Disease Relevance 0.71 Pain Relevance 0.06

Using free-flow micropuncture techniques, the proximal-distal single-nephron GFR difference was found to be augmented in aquaporin-1 and Na/H exchanger-3 knockout mice, suggesting TGF activation in these strains of mice.

Positive_regulation (activation) of TGF in nephron associated with targeted disruption and sprains and strains

6) Confidence 0.61 Published 1999 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 10589702 Disease Relevance 0.78 Pain Relevance 0.18

At this time, mRNA levels of TGF-beta1 were increased.

Positive_regulation (levels) of TGF-beta1

7) Confidence 0.61 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11123210 Disease Relevance 0.86 Pain Relevance 0.20

Increased plasma transforming growth factor-beta1 in migraine.

Positive_regulation (Increased) of plasma transforming growth factor-beta1 in plasma associated with migraine

8) Confidence 0.57 Published 2005 Journal Headache Section Title Doc Link 16178953 Disease Relevance 0.57 Pain Relevance 0.95

We have previously shown that an identical dose of CCl4 also produces a marked increase in serum TGF-beta 1 concentrations which peak at 48 hr and produce a marked inhibition of the anti-sRBC IgM antibody forming cell (AFC) response.

Positive_regulation (increase) of TGF-beta 1

9) Confidence 0.48 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.08

At this time, mRNA levels of TGF-beta1 were increased.

Positive_regulation (increased) of TGF-beta1

10) Confidence 0.41 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11123210 Disease Relevance 0.86 Pain Relevance 0.20

We next compared classical Ashcroft scoring with micro-CT based evaluation of TGF?

Positive_regulation (evaluation) of TGF

11) Confidence 0.40 Published 2010 Journal Respir Res Section Body Doc Link PMC3022722 Disease Relevance 0.52 Pain Relevance 0.26

Already 3 days following injection of P2-specific T-cells, TGF-beta 1 mRNA levels began to increase, peaked at day 6 at levels about tenfold above normal, and thereafter declined.

Positive_regulation (increase) of TGF-beta 1 mRNA in T-cells

12) Confidence 0.37 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 7505838 Disease Relevance 0.82 Pain Relevance 0.77

Such data indicate that the RT-induced response in vivo is associated with increased TGF-?

Positive_regulation (increased) of TGF

13) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2955039 Disease Relevance 1.04 Pain Relevance 0.65

Thrombospondin-1 (TSP-1) is a matricellular protein which regulates both in vitro and in vivo activation of latent TGF-?

Positive_regulation (activation) of TGF

14) Confidence 0.25 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 0.96 Pain Relevance 0.16

Twenty days after exposure to 15 Gy, a pronounced increase in TGF-?

Positive_regulation (increase) of TGF

15) Confidence 0.24 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2955039 Disease Relevance 0.52 Pain Relevance 0.26

Overexpression of the mRNAs of transforming growth factor-beta1, CD68, and monocyte chemoattractant protein-1 was noted in APN-KO mice but not in WT mice.

Positive_regulation (Overexpression) of transforming growth factor-beta1 in monocyte

16) Confidence 0.22 Published 2010 Journal J. Gastroenterol. Section Body Doc Link 20155376 Disease Relevance 0.06 Pain Relevance 0

Additionally, cell proliferation increased in epithelium infected with Smad7 adv consistent with suppression of injury-induced upregulation of TGFbeta1 in epithelium.

Positive_regulation (upregulation) of TGFbeta1 in epithelium associated with injury

17) Confidence 0.19 Published 2004 Journal Lab. Invest. Section Abstract Doc Link 15258599 Disease Relevance 0.17 Pain Relevance 0

Both medium and large amounts of HA were enhanced by the stimulation of TGF-beta 1.

Positive_regulation (stimulation) of TGF-beta 1

18) Confidence 0.19 Published 2004 Journal J. Dent. Res. Section Abstract Doc Link 14691111 Disease Relevance 0.33 Pain Relevance 0.41

The latter has been ascribed to increased levels of the ECM organizer, transforming growth factor-beta 1 (TGF-?

Positive_regulation (increased) of transforming growth factor-beta 1 in ECM

19) Confidence 0.15 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.90 Pain Relevance 0.16

These results suggested that the antianalgesic action of Dyn A is mediated by activation of opioid receptors that are positively coupled to adenylate cyclase through a Gs regulatory protein.

Positive_regulation (coupled) of regulatory protein associated with opioid receptor

20) Confidence 0.14 Published 1993 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7904072 Disease Relevance 0.48 Pain Relevance 0.55

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