INT48214

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Context Info
Confidence 0.47
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 5.98
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (SELL) plasma membrane (SELL)
Anatomy Link Frequency
monocytes 2
Lymphocytes 2
neutrophils 2
head 1
SELL (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 137 94.60 High High
cINOD 8 91.44 High High
rheumatoid arthritis 121 91.40 High High
methotrexate 3 91.08 High High
Inflammatory response 55 90.84 High High
aspirin 2 89.92 High High
cytokine 46 74.32 Quite High
chemokine 28 20.36 Low Low
metalloproteinase 13 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 146 99.76 Very High Very High Very High
Brain Injury 72 99.56 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 98.38 Very High Very High Very High
INFLAMMATION 209 94.60 High High
Death 6 93.36 High High
Rheumatoid Arthritis 121 91.40 High High
Osteoarthritis 18 86.92 High High
Injury 49 77.96 Quite High
Shock 7 64.56 Quite High
Sepsis 2 57.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lymphocytes from healthy subjects were preincubated with various concentrations of these substances and adhesion to plastic bound CD11a/CD18, CD11c/CD18, CD44 and CD62L mAbs was determined.
CD62L Binding (bound) of in Lymphocytes associated with adhesions
1) Confidence 0.47 Published 1999 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 10740409 Disease Relevance 0.76 Pain Relevance 0.38
Specific adhesion molecules important in mediating adhesive interactions include CD62L (L-selectin) and CD11b (Mac-1) on neutrophils and monocytes, which bind to their corresponding counter-receptors to facilitate leukocyte-endothelial cell interactions [5]–[8].
CD62L Binding (bind) of in monocytes associated with adhesions
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.64 Pain Relevance 0.18
Brief treatment of human peripheral blood lymphocytes with the potential anti-HIV compound aurintricarboxylic acid (ATA) prompts the selective release of already bound L-selectin-specific anti-Leu8 and anti-LAM1-1 antibodies from the cells.
L-selectin Binding (bound) of in lymphocytes associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.36 Published 1993 Journal Mol. Immunol. Section Abstract Doc Link 7505884 Disease Relevance 0.10 Pain Relevance 0
Specific disengagement of cell-bound anti-LAM-1 (anti-L-selectin) antibodies by aurintricarboxylic acid.
L-selectin Binding (disengagement) of
4) Confidence 0.36 Published 1993 Journal Mol. Immunol. Section Title Doc Link 7505884 Disease Relevance 0.10 Pain Relevance 0.06
Specific adhesion molecules important in mediating adhesive interactions include CD62L (L-selectin) and CD11b (Mac-1) on neutrophils and monocytes, which bind to their corresponding counter-receptors to facilitate leukocyte-endothelial cell interactions [5]–[8].
L-selectin Binding (bind) of in monocytes associated with adhesions
5) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.64 Pain Relevance 0.18
Our findings of initially low sL-selectin levels in TBI patients are consistent with earlier studies showing an inverse relationship between sL-selectin concentrations and increased risk of organ failure or death following isolated head injuries [80].
sL-selectin Binding (findings) of in head associated with death and brain injury
6) Confidence 0.28 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.98 Pain Relevance 0.08
Photobleaching fluorescence resonance energy transfer (pFRET) measurements on flow-sorted cells suggests that these two antibodies compete for the same epitope, while anti-LAM1-5-FITC and anti-Leu8-PE bind to distinct sites, although they also compete for binding.
anti-Leu8 Binding (bind) of
7) Confidence 0.26 Published 1993 Journal Mol. Immunol. Section Abstract Doc Link 7505884 Disease Relevance 0.08 Pain Relevance 0.08
Interestingly, the ATA-sensitive anti-Leu8 strongly competes with the ATA-resistant anti-LAM1-3 for binding.
anti-Leu8 Binding (competes) of
8) Confidence 0.20 Published 1993 Journal Mol. Immunol. Section Abstract Doc Link 7505884 Disease Relevance 0.09 Pain Relevance 0.06
Specific disengagement of cell-bound anti-LAM-1 (anti-L-selectin) antibodies by aurintricarboxylic acid.
anti-LAM-1 Binding (disengagement) of
9) Confidence 0.20 Published 1993 Journal Mol. Immunol. Section Title Doc Link 7505884 Disease Relevance 0.09 Pain Relevance 0.06
Combining the data on competition, pFRET and ATA effect, we suggest that the ATA sensitive anti-Leu8 and resistant anti-LAM1-3 bind to overlapping but non-identical epitopes.
anti-Leu8 Binding (bind) of
10) Confidence 0.20 Published 1993 Journal Mol. Immunol. Section Abstract Doc Link 7505884 Disease Relevance 0.07 Pain Relevance 0.09
Specific adhesion molecules important in mediating adhesive interactions include CD62L (L-selectin) and CD11b (Mac-1) on neutrophils and monocytes, which bind to their corresponding counter-receptors to facilitate leukocyte-endothelial cell interactions [5]–[8].
CD62L Binding (bind) of in neutrophils associated with adhesions
11) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.64 Pain Relevance 0.18
Specific adhesion molecules important in mediating adhesive interactions include CD62L (L-selectin) and CD11b (Mac-1) on neutrophils and monocytes, which bind to their corresponding counter-receptors to facilitate leukocyte-endothelial cell interactions [5]–[8].
L-selectin Binding (bind) of in neutrophils associated with adhesions
12) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.64 Pain Relevance 0.18
This antibody recognises sulphated carbohydrate structures on counterligands for L-selectin [26], which are expressed on HEV from lymphoid and chronically inflamed tissues [12].
L-selectin Binding (counterligands) of
13) Confidence 0.05 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 1.16 Pain Relevance 0.36

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