INT48217

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2010
Negated 7
Speculated 1
Reported most in Abstract
Documents 22
Total Number 23
Disease Relevance 21.12
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC4A3) plasma membrane (SLC4A3) transmembrane transport (SLC4A3)
Anatomy Link Frequency
smooth muscle 4
neuron 2
neuronal 1
multinucleated giant cells 1
muscle 1
SLC4A3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 98.00 Very High Very High Very High
fibrosis 1 97.92 Very High Very High Very High
imagery 18 92.44 High High
Angina 4 90.28 High High
cva 1 89.12 High High
abdominal pain 10 88.92 High High
Earache 1 88.36 High High
nud 5 87.36 High High
Pain 12 80.48 Quite High
palliative 2 80.44 Quite High
Disease Link Frequency Relevance Heat
Cancer 128 99.98 Very High Very High Very High
Carcinoma 32 99.76 Very High Very High Very High
Small Cell Lung Cancer 37 99.68 Very High Very High Very High
Renal Cancer 10 99.52 Very High Very High Very High
Necrosis 7 99.28 Very High Very High Very High
Disease 31 99.08 Very High Very High Very High
Malignant Fibrous Histiocytoma 11 98.88 Very High Very High Very High
Cold Sores 2 98.80 Very High Very High Very High
Cytomegalovirus Infection 3 98.24 Very High Very High Very High
INFLAMMATION 5 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The tumor cells expressed immunoreactivity for cytokeratin (AE1/AE3) and S-100.
Gene_expression (expressed) of AE3 associated with cancer
1) Confidence 0.75 Published 2009 Journal Indian J Pathol Microbiol Section Abstract Doc Link 19136797 Disease Relevance 0.66 Pain Relevance 0.08
Immunohistochemically, the neoplasm coexpressed vimentin and epithelial antigens (AE1/AE3, Cam 5.2, CK34betaE12, CK19 and EMA), most of them showing a peculiar immunostaining pattern in relation to the globular inclusions.
Gene_expression (coexpressed) of AE3 associated with cancer
2) Confidence 0.75 Published 2008 Journal APMIS Section Abstract Doc Link 19132990 Disease Relevance 1.12 Pain Relevance 0.13
Immunohistochemically, the neoplasm coexpressed vimentin and epithelial antigens (AE1/AE3, Cam 5.2, CK34betaE12, CK19 and EMA), most of them showing a peculiar immunostaining pattern in relation to the globular inclusions.
Gene_expression (coexpressed) of AE3 associated with cancer
3) Confidence 0.65 Published 2008 Journal APMIS Section Abstract Doc Link 19132990 Disease Relevance 1.12 Pain Relevance 0.13
Higher proportion of positive labeling of NSE, Syn, AE1/AE3, CD56, TTF-1, and CgA in PESCC was valuably applied in diagnosis and differential diagnosis.
Gene_expression (positive) of AE3
4) Confidence 0.65 Published 2010 Journal Dis. Esophagus Section Abstract Doc Link 19515193 Disease Relevance 0.67 Pain Relevance 0.12
The Ki-67 index (MIB-1) was >50%, but other markers such as cytokeratin AE1/AE3, smooth muscle actin, S-100 protein, CD34, and CD45 were negative.
Gene_expression (protein) of AE3 in smooth muscle
5) Confidence 0.65 Published 2008 Journal General thoracic and cardiovascular surgery Section Abstract Doc Link 19085056 Disease Relevance 0.82 Pain Relevance 0.07
Immunohistochemical staining of chromogranin A (CgA), neuron-specific enolase (NSE), synaptophysin (Syn), neuronal cell adhesion molecules (CD56), thyroid transcription factor-1 (TTF-1), cytokeration 34betaE12 (CK34betaE12), cytokeratin (AE1/AE3), and cytokeratin 10/13 was performed.
Gene_expression (/) of AE3 in neuronal associated with adhesions
6) Confidence 0.65 Published 2010 Journal Dis. Esophagus Section Abstract Doc Link 19515193 Disease Relevance 0.86 Pain Relevance 0.16
Histological findings showed necrosis and spindle tumor cells which were positive for AE1/AE3 and vimentin, and negative for calretinin, D2-40, and WT-1.
Neg (negative) Gene_expression (positive) of AE3 associated with necrosis and cancer
7) Confidence 0.65 Published 2010 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 20163019 Disease Relevance 1.52 Pain Relevance 0.07
Histological findings of specimens obtained from a percutaneous biopsy revealed spindle tumor cells, and the immunohistochemistry showed that the tumor cells were positive for CK-7, AE1/AE3, and vimentin and negative for calretinin, D2-40, and WT-1.
Neg (negative) Gene_expression (positive) of AE3 associated with cancer
8) Confidence 0.65 Published 2010 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 20163019 Disease Relevance 1.29 Pain Relevance 0.09
The foam cells were positive for CD68 and negative for AE1/AE3.
Neg (negative) Gene_expression (negative) of AE3 in foam cells
9) Confidence 0.65 Published 2003 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 14567739 Disease Relevance 0.45 Pain Relevance 0.19
Pancytokeratin (AE1/AE3) and LMWK (Cam5.2) are reported to be positive in all SmCC [22].
Gene_expression (positive) of AE3 associated with small cell lung cancer
10) Confidence 0.65 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC2034542 Disease Relevance 1.21 Pain Relevance 0.06
The lesional cells were strongly immunoreactive to CAM 5.2, 34 beta E12, AE1/AE3, EMA and vimentin.
Gene_expression (immunoreactive) of AE3
11) Confidence 0.65 Published 1999 Journal Pathology Section Abstract Doc Link 10643002 Disease Relevance 0.42 Pain Relevance 0.08
The multinucleated giant cells, in all cases, were strongly positive for cytokeratin AE1/AE3 and were negative for S-100, HSV I and II, CMV, and HPV-ISH.
Gene_expression (positive) of AE3 in multinucleated giant cells associated with genital human papilloma virus, cold sores and cytomegalovirus infection
12) Confidence 0.65 Published 1998 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 9422321 Disease Relevance 1.57 Pain Relevance 0.11
In all 7 lesions examined immunohistochemically, the tumor cells stained intensely positive for vimentin, S-100 protein, EMA, CAM5.2, AE1/AE3, and CK18 (Fig. 5d,e).
Spec (examined) Gene_expression (stained) of AE3 associated with cancer
13) Confidence 0.65 Published 2008 Journal Skeletal Radiol Section Body Doc Link PMC2257990 Disease Relevance 0.63 Pain Relevance 0
The Ki-67 index (MIB-1) was >50%, but other markers such as cytokeratin AE1/AE3, smooth muscle actin, S-100 protein, CD34, and CD45 were negative.
Neg (negative) Gene_expression (negative) of AE3 in smooth muscle
14) Confidence 0.65 Published 2008 Journal General thoracic and cardiovascular surgery Section Abstract Doc Link 19085056 Disease Relevance 0.83 Pain Relevance 0.07
Examination of the tumor by immunohistochemistry and electron microscopy indicated it to be neuroendocrine in nature, expressing synaptophysin and AE1/AE3, and containing dense core granules.
Gene_expression (expressing) of AE3 associated with cancer
15) Confidence 0.58 Published 2004 Journal World J Surg Oncol Section Abstract Doc Link PMC514615 Disease Relevance 1.17 Pain Relevance 0
These were negative for cytokeratin (AE1/AE3), HMB45, S100 protein, melanin A, NSE (neuron specific enolase), CD34 and CD 117.
Neg (negative) Gene_expression (negative) of AE3 in neuron
16) Confidence 0.58 Published 2008 Journal Cases J Section Body Doc Link PMC2584078 Disease Relevance 0.96 Pain Relevance 0.08
Immunohistochemically, the neoplastic cells were positive for vimentin, smooth muscle actin, desmin and calponin, negative for S-100 protein, CD34, CD31 and cytokeratins (AE1/AE3, Cam 5.2).
Neg (negative) Gene_expression (negative) of AE3 in smooth muscle
17) Confidence 0.58 Published 2005 Journal Pathologica Section Abstract Doc Link 16619980 Disease Relevance 0.15 Pain Relevance 0.08
Immunohistochemical studies showed weak membranous positivity for epithelial membrane antigen and focal cytoplasmic positivity for CD34; stains for smooth muscle actin, cytokeratin AE1/AE3, desmin, CD56, H-caldesmon, calponin, and S-100 protein were negative.
Neg (negative) Gene_expression (negative) of AE3 in smooth muscle
18) Confidence 0.58 Published 2005 Journal Ann Diagn Pathol Section Abstract Doc Link 16084452 Disease Relevance 0.96 Pain Relevance 0.10
Immunohistochemical staining showed cytokeratin AE1/AE3 and carcinoembryonic antigen positive in all samples, epithelial membrane antigen, S-100 and alpha-foetoprotein positive in two, neurone-specific enolase, chromogranin A, synaptophysin, and 5-hydroxytryptamine positive in one.
Gene_expression (positive) of AE3
19) Confidence 0.29 Published 2008 Journal Cancer Lett. Section Abstract Doc Link 18308466 Disease Relevance 0.34 Pain Relevance 0.16
By immunohistochemistry, the carcinoma cells were positive for cytokeratin AE1/AE3, cytokeratin 5/6, EMA, and MIC-2 (membranous staining).
Gene_expression (positive) of AE3 associated with carcinoma
20) Confidence 0.29 Published 2006 Journal Pediatr. Dev. Pathol. Section Abstract Doc Link 16944983 Disease Relevance 0.60 Pain Relevance 0.12

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