INT48218

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Context Info
Confidence 0.75
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 7.59
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (KRIT1) protein complex (KRIT1)
Anatomy Link Frequency
smooth muscle 1
neuron 1
muscle 1
striatum 1
oocytes 1
KRIT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 12 99.58 Very High Very High Very High
agonist 6 93.84 High High
headache 8 90.52 High High
cva 7 88.76 High High
imagery 4 87.96 High High
abdominal pain 3 84.20 Quite High
Central nervous system 6 83.44 Quite High
Pain 1 80.48 Quite High
pain pelvic 1 79.12 Quite High
dopamine receptor 1 72.48 Quite High
Disease Link Frequency Relevance Heat
Cancer 82 99.98 Very High Very High Very High
Renal Cancer 10 99.52 Very High Very High Very High
Adenocarcinoma 24 99.00 Very High Very High Very High
Neuroendocrine Cancer 62 98.08 Very High Very High Very High
Hyalinosis 1 93.68 High High
Transitional Cell Carcinoma 9 92.80 High High
Metastasis 16 91.00 High High
Carcinoma 50 90.88 High High
Headache 10 90.52 High High
Hemorrhage 6 88.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results indicated that repeated treatment with haloperidol, clozapine or risperidone increased CaM protein and CaMII mRNA levels but decreased calmodulin-dependent protein kinase IIalpha (CaMKIIalpha) IV (CaMKIV), kinase alpha (CaMKKalpha), kinase beta (CaMKKbeta) and calcineurin protein levels in the striatum of Sprague-Dawley rats (Rattus Norvegicus).
Gene_expression (levels) of CaM in striatum
1) Confidence 0.75 Published 2009 Journal Neuroscience Section Abstract Doc Link 19289156 Disease Relevance 0.21 Pain Relevance 0.07
Immunohistochemically, the neoplasm coexpressed vimentin and epithelial antigens (AE1/AE3, Cam 5.2, CK34betaE12, CK19 and EMA), most of them showing a peculiar immunostaining pattern in relation to the globular inclusions.
Gene_expression (coexpressed) of Cam associated with cancer
2) Confidence 0.75 Published 2008 Journal APMIS Section Abstract Doc Link 19132990 Disease Relevance 1.12 Pain Relevance 0.13
Immunohistochemically, the neoplastic cells were positive for vimentin, smooth muscle actin, desmin and calponin, negative for S-100 protein, CD34, CD31 and cytokeratins (AE1/AE3, Cam 5.2).
Neg (negative) Gene_expression (negative) of Cam in smooth muscle
3) Confidence 0.75 Published 2005 Journal Pathologica Section Abstract Doc Link 16619980 Disease Relevance 0.15 Pain Relevance 0.08
Deletion of KRIT1 gene and of the flanking genes was detected on the 384-well ABI Prism 7900 Sequence Detection System (Applied Biosystems) by the measurements of the amplicons Copy Number (CN) using a RT-QPCR approach with SYBR-Green I detection.
Gene_expression (Deletion) of KRIT1 gene
4) Confidence 0.67 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926733 Disease Relevance 0 Pain Relevance 0
The lesional cells were strongly immunoreactive to CAM 5.2, 34 beta E12, AE1/AE3, EMA and vimentin.
Gene_expression (immunoreactive) of CAM
5) Confidence 0.65 Published 1999 Journal Pathology Section Abstract Doc Link 10643002 Disease Relevance 0.42 Pain Relevance 0.08
Immunohistochemical staining was performed using Ventana Enhanced DAB Detection Kit and Biotin-StreptAvidin (B-SA) amplified methodology (Ventana, Tucson, AZ) and commercially available prediluted monoclonal antibodies against the following antigens: neuron specific enolase (NSE), synaptophysin, chromogranin, E-cadherin, pancytokeratin, CAM 5.2, and Ki-67 (all Ventana, Tucson, AZ).


Gene_expression (5.2) of CAM in neuron
6) Confidence 0.65 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC2174438 Disease Relevance 0.06 Pain Relevance 0
The CCM genes are identified as Krit 1 (CCM1), MGC4607 (CCM2), and PDCD10 (CCM3).
Gene_expression (identified) of Krit 1
7) Confidence 0.65 Published 2010 Journal Neurosurg Rev Section Abstract Doc Link 19760287 Disease Relevance 0.35 Pain Relevance 0.21
The CCM genes are identified as Krit 1 (CCM1), MGC4607 (CCM2), and PDCD10 (CCM3).
Gene_expression (identified) of CCM
8) Confidence 0.65 Published 2010 Journal Neurosurg Rev Section Abstract Doc Link 19760287 Disease Relevance 0.35 Pain Relevance 0.21
All tumours were negative for CAM 5.2, chromogranin, synaptophysin, Leu 7, neurofilament protein, muscle-specific actin (HHF-35) and desmin (D33).
Neg (negative) Gene_expression (negative) of CAM in muscle associated with cancer
9) Confidence 0.65 Published 1996 Journal Histopathology Section Abstract Doc Link 8872144 Disease Relevance 0.55 Pain Relevance 0.08
Immunohistochemically, the neoplasm coexpressed vimentin and epithelial antigens (AE1/AE3, Cam 5.2, CK34betaE12, CK19 and EMA), most of them showing a peculiar immunostaining pattern in relation to the globular inclusions.
Gene_expression (5.2) of Cam associated with cancer
10) Confidence 0.65 Published 2008 Journal APMIS Section Abstract Doc Link 19132990 Disease Relevance 1.10 Pain Relevance 0.12
In addition, injection of CaM kinase II in Xenopus oocytes led only to desensitization of expressed rMOR1, but not of an S261A/S266A receptor mutant.
Gene_expression (injection) of CaM in oocytes
11) Confidence 0.65 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9326307 Disease Relevance 0 Pain Relevance 0.37
The tumor tissue infiltrating the lymphatics, which seemed to be RCC, demonstrated positive staining for EMA and keratins CAM-5.2, AE1/AE3, and MAK-6 and negative staining for keratin 34 beta E12.
Gene_expression (staining) of CAM associated with cancer and renal cancer
12) Confidence 0.65 Published 1994 Journal Cancer Section Abstract Doc Link 7506117 Disease Relevance 1.89 Pain Relevance 0.07
To investigate the role of calcium/calmodulin-dependent protein kinase II (CaM kinase II) on mu-opioid receptor desensitization, we coexpressed rMOR1 and constitutively active CaM kinase II in HEK293 cells.
Gene_expression (coexpressed) of CaM associated with opioid receptor
13) Confidence 0.58 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9326307 Disease Relevance 0 Pain Relevance 0.37
Pancytokeratin, E-cadherin, and CAM 5.2 immunolabeling was present in both the signet-cell adenocarcinoma and the neuroendocrine tumor components.
Gene_expression (present) of CAM associated with adenocarcinoma and neuroendocrine cancer
14) Confidence 0.58 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC2174438 Disease Relevance 1.41 Pain Relevance 0
A significant multiplicative interaction was found only for emotional demands and job control.
Gene_expression (found) of interaction
15) Confidence 0.15 Published 2010 Journal Int J Behav Med Section Body Doc Link PMC2862948 Disease Relevance 0 Pain Relevance 0
For pull-down experiments, vectors encoding FLAG-tagged Krit1 and OSM were transfected into HEK293 cells (the American Type Culture Collection (ATCC) Rockville, MA, USA) using lipofectamine.
Gene_expression (transfected) of Krit1
16) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

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