INT48219

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2011
Negated 10
Speculated 0
Reported most in Abstract
Documents 34
Total Number 36
Disease Relevance 33.18
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC4A1) transmembrane transport (SLC4A1)
Anatomy Link Frequency
smooth muscle 5
spindle cells 2
neuron 2
erythrocyte 1
muscle 1
SLC4A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 35 98.00 Very High Very High Very High
fibrosis 1 97.92 Very High Very High Very High
imagery 16 92.60 High High
Pain 12 92.40 High High
Angina 4 90.28 High High
anesthesia 1 89.36 High High
cva 1 89.28 High High
abdominal pain 12 89.08 High High
Earache 1 88.36 High High
nud 5 87.36 High High
Disease Link Frequency Relevance Heat
Cancer 511 99.98 Very High Very High Very High
Carcinoma 70 99.76 Very High Very High Very High
Small Cell Lung Cancer 37 99.68 Very High Very High Very High
Ependymoma 37 99.62 Very High Very High Very High
Renal Cancer 10 99.52 Very High Very High Very High
Necrosis 8 99.28 Very High Very High Very High
Disease 24 99.08 Very High Very High Very High
Malignant Fibrous Histiocytoma 19 98.88 Very High Very High Very High
Cold Sores 2 98.64 Very High Very High Very High
Chondrosarcoma 38 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical studies showed weak membranous positivity for epithelial membrane antigen and focal cytoplasmic positivity for CD34; stains for smooth muscle actin, cytokeratin AE1/AE3, desmin, CD56, H-caldesmon, calponin, and S-100 protein were negative.
Neg (negative) Gene_expression (negative) of AE1 in smooth muscle
1) Confidence 0.75 Published 2005 Journal Ann Diagn Pathol Section Abstract Doc Link 16084452 Disease Relevance 0.96 Pain Relevance 0.10
Immunohistochemically, the neoplasm coexpressed vimentin and epithelial antigens (AE1/AE3, Cam 5.2, CK34betaE12, CK19 and EMA), most of them showing a peculiar immunostaining pattern in relation to the globular inclusions.
Gene_expression (coexpressed) of AE1 associated with cancer
2) Confidence 0.75 Published 2008 Journal APMIS Section Abstract Doc Link 19132990 Disease Relevance 1.12 Pain Relevance 0.13
Pathological examination revealed hypercellularity of spindle cells, that showed positive for CD34, vimentin, desmin and Mic-2, and negative for S100, alphaSMA, c-kit, AE1/3, p53 and bcl-2.
Neg (negative) Gene_expression (negative) of AE1 in spindle cells associated with hyperplasia
3) Confidence 0.75 Published 2010 Journal Hinyokika Kiyo Section Abstract Doc Link 20610922 Disease Relevance 0.65 Pain Relevance 0.07
Immunohistochemically, the neoplastic cells were positive for vimentin, smooth muscle actin, desmin and calponin, negative for S-100 protein, CD34, CD31 and cytokeratins (AE1/AE3, Cam 5.2).
Neg (negative) Gene_expression (negative) of AE1 in smooth muscle
4) Confidence 0.75 Published 2005 Journal Pathologica Section Abstract Doc Link 16619980 Disease Relevance 0.15 Pain Relevance 0.08
In our case these markers were negative and CK AE1/AE3 was strongly and diffusely positive in whole tumor including pseudoglandular and acantholytic areas.
Gene_expression (/) of AE1 associated with cancer
5) Confidence 0.65 Published 2011 Journal Diagn Pathol Section Body Doc Link PMC3024921 Disease Relevance 1.87 Pain Relevance 0
Higher proportion of positive labeling of NSE, Syn, AE1/AE3, CD56, TTF-1, and CgA in PESCC was valuably applied in diagnosis and differential diagnosis.
Gene_expression (positive) of AE1
6) Confidence 0.65 Published 2010 Journal Dis. Esophagus Section Abstract Doc Link 19515193 Disease Relevance 0.67 Pain Relevance 0.12
Immunohistochemical staining of chromogranin A (CgA), neuron-specific enolase (NSE), synaptophysin (Syn), neuronal cell adhesion molecules (CD56), thyroid transcription factor-1 (TTF-1), cytokeration 34betaE12 (CK34betaE12), cytokeratin (AE1/AE3), and cytokeratin 10/13 was performed.
Gene_expression (/) of AE1 in neuronal associated with adhesions
7) Confidence 0.65 Published 2010 Journal Dis. Esophagus Section Abstract Doc Link 19515193 Disease Relevance 0.86 Pain Relevance 0.16
Histological findings showed necrosis and spindle tumor cells which were positive for AE1/AE3 and vimentin, and negative for calretinin, D2-40, and WT-1.
Neg (negative) Gene_expression (positive) of AE1 associated with necrosis and cancer
8) Confidence 0.65 Published 2010 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 20163019 Disease Relevance 1.52 Pain Relevance 0.07
The tumor tissue infiltrating the lymphatics, which seemed to be RCC, demonstrated positive staining for EMA and keratins CAM-5.2, AE1/AE3, and MAK-6 and negative staining for keratin 34 beta E12.
Gene_expression (staining) of AE1 associated with cancer and renal cancer
9) Confidence 0.65 Published 1994 Journal Cancer Section Abstract Doc Link 7506117 Disease Relevance 1.89 Pain Relevance 0.07
E12 (M0630, 1:100, 1 hr; Dako, Mississauga, ON), mouse monoclonal Vimentin (Vim3B4, 1:200, 1 hr; American Research Products, Belmont, MA), mouse monoclonal E-cadherin (36B5, 1:100, overnight; Vector Labs, Burlington, ON), mouse monoclonal p63(7JUL, 1:50, 2 hrs; Vector Labs) and human cytokeratin cocktail (AE1/AE3, 1:200, 1 hr; Dako).
Gene_expression (/) of AE1
10) Confidence 0.65 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 0 Pain Relevance 0
Immunohistochemically, strong staining for cytokeratin (CK) AE1/AE3 was observed in all tumor cells, but not in OGCs (Figure 1G).
Gene_expression (staining) of AE1 associated with cancer
11) Confidence 0.65 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2936386 Disease Relevance 0.95 Pain Relevance 0.05
The spindle-shaped tumor cells constituting most of the tumor were not reactive for CK AE1/AE3, but instead were strongly positive for vimentin (Figure 1P).
Neg (not) Gene_expression (reactive) of AE1 associated with cancer
12) Confidence 0.65 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2936386 Disease Relevance 1.36 Pain Relevance 0.07
Immunohistochemically tumor cells were diffusely positive for CK AE1/AE3 (Figure 1G) and focally positive for epithelial membrane antigen and syndecan 1 (Figure 1H).
Gene_expression (positive) of AE1 associated with cancer
13) Confidence 0.65 Published 2011 Journal Diagn Pathol Section Body Doc Link PMC3024921 Disease Relevance 0.99 Pain Relevance 0.03
Immunohistochemically tumor cells were diffusely positive for cytokeratin (CK) AE1/AE3 and focally positive for epithelial membrane antigen and syndecan 1.
Gene_expression (positive) of AE1 associated with cancer
14) Confidence 0.65 Published 2011 Journal Diagn Pathol Section Abstract Doc Link PMC3024921 Disease Relevance 1.46 Pain Relevance 0
The Ki-67 index (MIB-1) was >50%, but other markers such as cytokeratin AE1/AE3, smooth muscle actin, S-100 protein, CD34, and CD45 were negative.
Neg (negative) Gene_expression (negative) of AE1 in smooth muscle
15) Confidence 0.65 Published 2008 Journal General thoracic and cardiovascular surgery Section Abstract Doc Link 19085056 Disease Relevance 0.83 Pain Relevance 0.07
The Ki-67 index (MIB-1) was >50%, but other markers such as cytokeratin AE1/AE3, smooth muscle actin, S-100 protein, CD34, and CD45 were negative.
Gene_expression (protein) of AE1 in smooth muscle
16) Confidence 0.65 Published 2008 Journal General thoracic and cardiovascular surgery Section Abstract Doc Link 19085056 Disease Relevance 0.83 Pain Relevance 0.07
The spindle cells were focally positive with calretinin in 2 cases, CD56 in 2, AE1/3 in 4, smooth muscle actin in 12, and desmin in 8 cases, and negative with alpha-inhibin, epithelial membrane antigen, beta-catenin, CD34, and transforming growth factor-beta, with focal nuclear positivity for estrogen receptor in 5 and progesterone receptor in 11 cases.
Gene_expression (positive) of AE1 in spindle cells
17) Confidence 0.65 Published 2008 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18636018 Disease Relevance 0.73 Pain Relevance 0.09
The foam cells were positive for CD68 and negative for AE1/AE3.
Neg (negative) Gene_expression (negative) of AE1 in foam cells
18) Confidence 0.65 Published 2003 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 14567739 Disease Relevance 0.45 Pain Relevance 0.19
Immunohistochemically, neoplastic cells diffusely stained with anti-vimentin antibodies and were focally positive for chromogranin A, neuron-specific enolase, lysozyme, and cytokeratins AE1/AE3.
Gene_expression (positive) of AE1 in neuron
19) Confidence 0.65 Published 2001 Journal Ultrastruct Pathol Section Abstract Doc Link 11297323 Disease Relevance 1.05 Pain Relevance 0.13
The lesional cells were strongly immunoreactive to CAM 5.2, 34 beta E12, AE1/AE3, EMA and vimentin.
Gene_expression (immunoreactive) of AE1
20) Confidence 0.65 Published 1999 Journal Pathology Section Abstract Doc Link 10643002 Disease Relevance 0.42 Pain Relevance 0.08

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