INT48222

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2010
Negated 6
Speculated 0
Reported most in Body
Documents 123
Total Number 141
Disease Relevance 78.04
Pain Relevance 37.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
neutrophils 21
epithelial cells 18
fibroblasts 10
monocyte 10
Caco-2 10
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1741 100.00 Very High Very High Very High
Morphine 1443 100.00 Very High Very High Very High
cytokine 955 100.00 Very High Very High Very High
metalloproteinase 433 100.00 Very High Very High Very High
chemokine 310 100.00 Very High Very High Very High
fibrosis 57 100.00 Very High Very High Very High
Inflammatory stimuli 27 100.00 Very High Very High Very High
narcan 70 99.98 Very High Very High Very High
substance P 64 99.98 Very High Very High Very High
ischemia 28 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2152 100.00 Very High Very High Very High
Cancer 887 100.00 Very High Very High Very High
Sepsis 352 100.00 Very High Very High Very High
Necrosis 94 100.00 Very High Very High Very High
Osteoporosis 48 100.00 Very High Very High Very High
Cystic Fibrosis 36 100.00 Very High Very High Very High
Nicotine Addiction 571 99.98 Very High Very High Very High
Nociception 40 99.98 Very High Very High Very High
Cv Unclassified Under Development 35 99.98 Very High Very High Very High
Alagille Syndrome 60 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunosuppressant cyclosporin A (50 microM) partially reduced the ischemia-stimulated IL-8 and MCP-1 secretion by HCEC.
Positive_regulation (stimulated) of Localization (secretion) of IL-8 in HCEC associated with ischemia
1) Confidence 0.59 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 1.14 Pain Relevance 0.60
The protein kinase C (PKC) inhibitor, Go6976, also significantly reduced the stimulatory effect of pyocyanin on IL-1beta, and PDBu increased IL-8 release.
Positive_regulation (increased) of Localization (release) of IL-8 associated with kinase c
2) Confidence 0.56 Published 2006 Journal Respir Med Section Abstract Doc Link 16448811 Disease Relevance 0.28 Pain Relevance 0.36
While VEGF, PTHrP, and IL-11, all of which are critical regulators of tumor angiogenesis [26], [38] and osteoclast resorption [2], [11]–[13], [36], were not affected by the presence of HA, IL-8 secretion increased under these conditions.
Positive_regulation (increased) of Localization (secretion) of IL-8 in osteoclast associated with cancer
3) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809751 Disease Relevance 0.96 Pain Relevance 0.09
While VEGF and IL-11 secretion by MDA-MB231 cells were not affected by the scaffold type (Fig. 5A) and PTHrP was secreted at undetectable levels (<0.3 pM) from either mineralized or non-mineralized tumor models (data not shown), IL-8 secretion was increased by 38% in mineralized scaffolds HA (Fig 5A).
Positive_regulation (increased) of Localization (secretion) of IL-8 associated with cancer
4) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809751 Disease Relevance 0.57 Pain Relevance 0
signaling to increase IL-8 secretion.
Positive_regulation (increase) of Localization (secretion) of IL-8
5) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809751 Disease Relevance 0.77 Pain Relevance 0.07
In addition, we confirmed IL-8 mRNA expression and secretion of IL-8 by an endometrial cancer cell line (Ishikawa) using the reverse transcriptase-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) methods, respectively.
Positive_regulation (confirmed) of Localization (secretion) of IL-8 associated with endometriosis (extended)
6) Confidence 0.50 Published 1994 Journal J. Reprod. Immunol. Section Abstract Doc Link 7738906 Disease Relevance 0.26 Pain Relevance 0.08
g/per nostril) induce time-dependent nasal IL-8 release in normal subjects.
Positive_regulation (induce) of Localization (release) of IL-8 in nasal
7) Confidence 0.45 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0.43 Pain Relevance 0.31
Inhibitory effects at 0.5 mg/ml of native, polymeric AAT and Prolastin on zymosan-mediated IL-8 release
Positive_regulation (mediated) of Localization (release) of IL-8
8) Confidence 0.45 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0 Pain Relevance 0.03
However, during the next session, when 30 min after challenge with LPS, Prolastin (2.5 mg/ per nostril) was instilled, no induction of nasal IL-8 release was found compared to the basal levels.
Neg (no) Positive_regulation (induction) of Localization (release) of IL-8 in nasal
9) Confidence 0.45 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0.42 Pain Relevance 0.29
Increase of intracellular Ca(2+) resulted in inducing IL-8 gene expression and protein secretion, and addition of EGTA or BAPTA/AM before Ca(2+) stimulation inhibited the induction of IL-8 production.
Positive_regulation (resulted) of Localization (secretion) of IL-8
10) Confidence 0.44 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.15 Pain Relevance 0.18
Increase of intracellular Ca(2+) resulted in inducing IL-8 gene expression and protein secretion, and addition of EGTA or BAPTA/AM before Ca(2+) stimulation inhibited the induction of IL-8 production.
Positive_regulation (inducing) of Localization (secretion) of IL-8
11) Confidence 0.44 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.15 Pain Relevance 0.18
Co-culture of hRPE cells with monocytes increased steady-state IL-8 and MCP-1 mRNA and protein secretion.
Positive_regulation (increased) of Localization (secretion) of IL-8 in monocytes
12) Confidence 0.44 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.14 Pain Relevance 0.17
In this study, we show that human cere-bromicrovascular endothelial cells (HCEC) subjected to a 4 h in vitro ischemia (hypoxia + glucose deprivation) followed by a 4-24 h recovery express elevated levels of ICAM-1, IL-8, and MCP-1 mRNAs (semi-quantitative RT-PCR) and secrete increased amounts of the immunoreactive chemokines IL-8 and MCP-1 (ELISA).
Positive_regulation (elevated) of Localization (levels) of IL-8 in HCEC associated with chemokine, hypoxia and ischemia
13) Confidence 0.43 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 0.97 Pain Relevance 0.43
We cannot determine from these experiments whether Prolastin is directly suppressing IL-8 release or suppressing another inflammatory response that leads to IL-8 release; nonetheless, our finding suggests that effects of Prolastin directed against endotoxin-stimulated inflammatory responses may be beneficial.
Positive_regulation (leads) of Localization (release) of IL-8 associated with inflammatory response
14) Confidence 0.41 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0.42 Pain Relevance 0.28
The IL-8 release in response to LPS challenge increased over time compared to baseline levels (Fig. 4).
Positive_regulation (increased) of Localization (release) of IL-8
15) Confidence 0.41 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0.25 Pain Relevance 0.03
In conclusion, this study shows that PKC signal pathway seems to be involved in the pyocyanin-mediated upregulation of the IL-1beta and PDBu-induced IL-8 release in BEAS-2B cells.
Positive_regulation (upregulation) of Localization (release) of IL-8 in BEAS-2B associated with kinase c
16) Confidence 0.41 Published 2006 Journal Respir Med Section Abstract Doc Link 16448811 Disease Relevance 0.29 Pain Relevance 0.37
The ischemia-induced expression of ICAM-1 in HCEC, and the expression/release of IL-8 and MCP-1 in HCEC were abolished by the non-steroid anti-inflammatory drug, indomethacin (100-300 microM).
Positive_regulation (induced) of Localization (expression/release) of IL-8 in HCEC associated with inflammation and ischemia
17) Confidence 0.40 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 1.13 Pain Relevance 0.52
In other cell types such as alveolar macrophages, it has been shown that H2O2 and cigarette smoke can stimulate IL-8 secretion by inhibiting the activity of HDAC enzymes (Ito et al 2001).
Positive_regulation (stimulate) of Localization (secretion) of IL-8 in alveolar macrophages
18) Confidence 0.39 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.96 Pain Relevance 0.10
In this regard, we have reported that H2O2 elicited a concentration-dependent increase in the amount of IL-8 released from bronchial epithelial cells, whose apoptotic death was also stimulated by oxidative stress (Pelaia et al 2004).
Positive_regulation (increase) of Localization (released) of IL-8 in epithelial cells associated with stress, apoptosis and death
19) Confidence 0.39 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 1.23 Pain Relevance 0.09
In our observation, ICD did not significantly induce IL-8 secretion in differentiated, cultured macrophages.
Neg (not) Positive_regulation (induce) of Localization (secretion) of IL-8 in macrophages
20) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2195454 Disease Relevance 0.35 Pain Relevance 0.13

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