INT48232

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 2
Speculated 5
Reported most in Abstract
Documents 245
Total Number 255
Disease Relevance 96.31
Pain Relevance 57.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP1) extracellular region (MMP1) proteinaceous extracellular matrix (MMP1)
Anatomy Link Frequency
fibroblasts 30
chondrocytes 19
joints 4
cartilage 4
tendon cells 3
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 4495 100.00 Very High Very High Very High
cytokine 1133 99.82 Very High Very High Very High
agonist 66 99.76 Very High Very High Very High
Inflammatory stimuli 31 99.74 Very High Very High Very High
Inflammation 1483 99.52 Very High Very High Very High
Arthritis 464 99.44 Very High Very High Very High
qutenza 36 99.42 Very High Very High Very High
Osteoarthritis 1825 99.38 Very High Very High Very High
chemokine 163 99.32 Very High Very High Very High
endometriosis 444 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Wound Healing 194 100.00 Very High Very High Very High
Breast Cancer 182 100.00 Very High Very High Very High
Gingival Overgrowth 110 99.98 Very High Very High Very High
Rupture 64 99.92 Very High Very High Very High
Carcinoma 61 99.92 Very High Very High Very High
Pancreatic Cancer 53 99.92 Very High Very High Very High
Endometriosis 586 99.84 Very High Very High Very High
Atherosclerotic Plaque 48 99.84 Very High Very High Very High
Shock 109 99.82 Very High Very High Very High
Cancer 868 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of MMP-1 mRNA was also detected in two human pancreatic carcinoma cell lines and three pancreatic carcinoma tissues by the reverse transcription polymerase chain reaction method.
Gene_expression (Expression) of MMP-1 mRNA associated with pancreatic cancer
1) Confidence 0.78 Published 1999 Journal Mod. Pathol. Section Abstract Doc Link 10430270 Disease Relevance 1.48 Pain Relevance 0.11
Expression of the MMP-1 in human pancreatic carcinoma: relationship with prognostic factor.
Gene_expression (Expression) of MMP-1 associated with pancreatic cancer
2) Confidence 0.78 Published 1999 Journal Mod. Pathol. Section Title Doc Link 10430270 Disease Relevance 1.10 Pain Relevance 0.13
These findings suggest that MMP-1 expression is related to the carcinogenesis and prognosis of human pancreatic ductal adenocarcinoma.
Gene_expression (expression) of MMP-1 associated with adenocarcinoma
3) Confidence 0.78 Published 1999 Journal Mod. Pathol. Section Abstract Doc Link 10430270 Disease Relevance 1.34 Pain Relevance 0.05
MMP-1 was expressed in the carcinoma cells themselves and in stromal fibroblasts.
Gene_expression (expressed) of MMP-1 in fibroblasts associated with carcinoma
4) Confidence 0.78 Published 1999 Journal Mod. Pathol. Section Abstract Doc Link 10430270 Disease Relevance 1.49 Pain Relevance 0.10
MMP-1 was expressed faintly in fetal and normal pancreatic tissues.
Gene_expression (expressed) of MMP-1
5) Confidence 0.78 Published 1999 Journal Mod. Pathol. Section Abstract Doc Link 10430270 Disease Relevance 1.18 Pain Relevance 0.13
MMP-1 expression, however, had no relation to the presence of lymph node metastasis, tumor size, or tumor-node-metastasis stage in pancreatic carcinomas.
Gene_expression (expression) of MMP-1 in node associated with cancer, pancreatic cancer and metastasis
6) Confidence 0.78 Published 1999 Journal Mod. Pathol. Section Abstract Doc Link 10430270 Disease Relevance 1.48 Pain Relevance 0.09
However, only nimesulide had the ability to significantly reduce collagenase synthesis.
Gene_expression (synthesis) of collagenase
7) Confidence 0.77 Published 1993 Journal Drugs Section Abstract Doc Link 7506192 Disease Relevance 0.25 Pain Relevance 0.31
RESULTS: In general, median expression of MMP-1 in the ulcer tissue was significantly increased compared to the surrounding mucosa (16.8 [4.7-33.4] vs. 10.9 [2.8-17.8] ng/mg protein) (p < 0.001).
Gene_expression (expression) of MMP-1
8) Confidence 0.77 Published 2000 Journal Z Gastroenterol Section Body Doc Link 11132534 Disease Relevance 0.16 Pain Relevance 0
On the basis of the concept that MMPs are synthesized in tissue and released into the blood stream we evaluated the levels of MMPs, their inhibitors, and MTC1 in blood plasma from patients with TCC of the bladder at different grades, stages, and with and without metastasis.
Gene_expression (synthesized) of MMP in blood associated with metalloproteinase, metastasis and transitional cell carcinoma
9) Confidence 0.75 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.90 Pain Relevance 0.21
This project was originally designed to examine the expression of MMPs and the tissue inhibitors of MMPs (TIMPs) by diseased human TMJ synovial fibroblasts and to determine their ability to degrade Type I collagen.
Spec (examine) Gene_expression (expression) of MMP in fibroblasts associated with snapping jaw and metalloproteinase
10) Confidence 0.75 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15652180 Disease Relevance 0.51 Pain Relevance 0.78
These studies have shown that high strains (or long duty cycles) applied by stretching bioreactors can cause tenocytes to produce abnormal levels of matrix metalloproteases (MMPs), which would in turn degrade the collagen and cause degeneration [131,137-144].
Gene_expression (produce) of MMP associated with sprains and strains
11) Confidence 0.75 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2695438 Disease Relevance 0.92 Pain Relevance 0.08
The study revealed that the most highly expressed MMPs are located in the stroma, except MMP13, which was located in the epithelium.
Gene_expression (expressed) of MMP in stroma associated with metalloproteinase
12) Confidence 0.75 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.86 Pain Relevance 0.21
The protection of matrix degradation in response to IL-1 by sierrasil may reflect a reduction in matrix metalloprotease (MMP) production (also transcriptionally regulated in response to IL-1?)
Gene_expression (production) of MMP
13) Confidence 0.75 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1276811 Disease Relevance 0.45 Pain Relevance 0.25
Taking these aspects into account, the present study evidences no systematic induction of MMP-1 mRNA expression or other undesired effects with high or even disproportionally high irradiances and irradiation doses of wIRA in skin fibroblast cultures, supporting the notion that wIRA does not bring along noxious consequences when clinically administered in an appropriate form.
Gene_expression (expression) of MMP-1 mRNA in skin
14) Confidence 0.74 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0.07 Pain Relevance 0
We measured the gene expression of MMP-1 (Hs00233958_m1) and actin (Hs99999903_m1) using assay-on-demand primers (Applied Biosystems, Foster City, California, USA).
Gene_expression (expression) of MMP-1
15) Confidence 0.74 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0 Pain Relevance 0
Even with an extreme single irradiation dose of 3951 J/cm² (which would mean an irradiance of 1098 mW/cm², if administered during 1 hour; an irradiance is not presented) Kim et al. [53] found no increase of MMP-1 mRNA expression after single infrared irradiation, but only after multiple irradiations.
Gene_expression (expression) of MMP-1 mRNA
16) Confidence 0.74 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0.09 Pain Relevance 0
Conclusions: wIRA(+RL) even at the investigated disproportionally high irradiances does not induce cell death or a systematic increase of MMP-1 mRNA expression, both of which can be easily induced by UV-A radiation.
Gene_expression (expression) of MMP-1 mRNA associated with death
17) Confidence 0.74 Published 2007 Journal GMS German Medical Science Section Abstract Doc Link PMC2703241 Disease Relevance 0.25 Pain Relevance 0.03
These data suggest that HA inhibits the expression and production of MMP-1 and MMP-3 in IL-1beta-stimulated human synovial cells.
Gene_expression (expression) of MMP-1 in synovial cells associated with metalloproteinase
18) Confidence 0.68 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15383690 Disease Relevance 0.18 Pain Relevance 0.88
We therefore prepose that intra-articular HA may rescue inflamed joints from bone and cartilage destruction by reducing the production of MMP-1 and MMP-3.
Gene_expression (production) of MMP-1 in cartilage associated with metalloproteinase
19) Confidence 0.68 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15383690 Disease Relevance 0.06 Pain Relevance 0.75
The IL-1beta-mediated induction of MMP-1 mRNA expression was attenuated by 10 microg/ml HA (p=0.026) and that of MMP-3 mRNA was strongly down-regulated in the presence of 10 or 1000 microg/ml HA (p<0.001).
Gene_expression (expression) of MMP-1 mRNA associated with metalloproteinase
20) Confidence 0.68 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15383690 Disease Relevance 0.22 Pain Relevance 0.89

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