INT48233

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Context Info
Confidence 0.58
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 34
Total Number 39
Disease Relevance 12.94
Pain Relevance 9.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP1) extracellular region (MMP1) proteinaceous extracellular matrix (MMP1)
Anatomy Link Frequency
chondrocytes 8
cartilage 8
fibroblasts 6
epithelial cells 2
endometrium 2
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 651 100.00 Very High Very High Very High
Osteoarthritis 337 99.44 Very High Very High Very High
endometriosis 168 97.92 Very High Very High Very High
qutenza 8 97.92 Very High Very High Very High
Snapping jaw 8 97.88 Very High Very High Very High
Inflammation 272 97.72 Very High Very High Very High
cytokine 159 97.52 Very High Very High Very High
rheumatoid arthritis 233 96.76 Very High Very High Very High
Arthritis 91 96.36 Very High Very High Very High
Hippocampus 11 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 9 99.82 Very High Very High Very High
Lung Injury 1 99.48 Very High Very High Very High
Osteoarthritis 306 99.44 Very High Very High Very High
Targeted Disruption 1 99.10 Very High Very High Very High
Endometriosis 224 97.92 Very High Very High Very High
Temporomandibular Joint Syndrome 8 97.88 Very High Very High Very High
Hypertrophy 22 97.80 Very High Very High Very High
INFLAMMATION 313 97.72 Very High Very High Very High
Osteoporosis 21 97.68 Very High Very High Very High
Chondrosarcoma 54 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, only nimesulide had the ability to significantly reduce collagenase synthesis.
Negative_regulation (reduce) of Gene_expression (synthesis) of collagenase
1) Confidence 0.58 Published 1993 Journal Drugs Section Abstract Doc Link 7506192 Disease Relevance 0.25 Pain Relevance 0.31
This project was originally designed to examine the expression of MMPs and the tissue inhibitors of MMPs (TIMPs) by diseased human TMJ synovial fibroblasts and to determine their ability to degrade Type I collagen.
Spec (examine) Negative_regulation (examine) of Spec (examine) Gene_expression (expression) of MMP in fibroblasts associated with snapping jaw and metalloproteinase
2) Confidence 0.41 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15652180 Disease Relevance 0.51 Pain Relevance 0.78
The protection of matrix degradation in response to IL-1 by sierrasil may reflect a reduction in matrix metalloprotease (MMP) production (also transcriptionally regulated in response to IL-1?)
Negative_regulation (reduction) of Gene_expression (production) of MMP
3) Confidence 0.41 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1276811 Disease Relevance 0.45 Pain Relevance 0.26
Heat-shock-induced MMP-1 expression was decreased by treatment of the TRPV1 inhibitors (capsazepine and ruthenium red) or knockdown of TRPV1 using RNA interference in HaCaT cells.
Negative_regulation (decreased) of Gene_expression (expression) of MMP-1 associated with shock and metalloproteinase
4) Confidence 0.41 Published 2007 Journal J. Invest. Dermatol. Section Abstract Doc Link 17508023 Disease Relevance 0.63 Pain Relevance 0.48
These data suggest that HA inhibits the expression and production of MMP-1 and MMP-3 in IL-1beta-stimulated human synovial cells.
Negative_regulation (inhibits) of Gene_expression (expression) of MMP-1 in synovial cells associated with metalloproteinase
5) Confidence 0.37 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15383690 Disease Relevance 0.19 Pain Relevance 0.88
We therefore prepose that intra-articular HA may rescue inflamed joints from bone and cartilage destruction by reducing the production of MMP-1 and MMP-3.
Negative_regulation (reducing) of Gene_expression (production) of MMP-1 in cartilage associated with metalloproteinase
6) Confidence 0.37 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15383690 Disease Relevance 0.06 Pain Relevance 0.75
Knock-down of TRPV1 using siRNA transfection also decreased MMP-1 expression, as well as UV-induced Ca(2+) influx in HaCaT.
Negative_regulation (decreased) of Gene_expression (expression) of MMP-1 associated with targeted disruption and metalloproteinase
7) Confidence 0.36 Published 2009 Journal J. Cell. Physiol. Section Abstract Doc Link 19206161 Disease Relevance 0.10 Pain Relevance 0.70
Pretreatment with 2.5 and 10 mmol/l glucosamine was able, to differing degrees, to downregulate mRNA and protein levels of MMP-1, MMP-3 and MMP-13.
Negative_regulation (downregulate) of Gene_expression (levels) of MMP-1
8) Confidence 0.34 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0.31 Pain Relevance 0.12
ligand rosiglitazone suppresses MMP-1 and MMP13 gene expression more effectively than either compound alone.
Negative_regulation (suppresses) of Gene_expression (expression) of MMP-1
9) Confidence 0.34 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.13 Pain Relevance 0.03
As a result, combined treatment should lead to greater inhibition of MMP-1 and MMP-13 gene expression compared with either compound alone.
Negative_regulation (inhibition) of Gene_expression (expression) of MMP-1
10) Confidence 0.34 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.13 Pain Relevance 0.03
Both the inhibition of MMP-13 and the potentiation of MMP-1 expression by fluoroquinolones were accompanied by corresponding changes in IL-1beta-stimulated MMP output.
Negative_regulation (inhibition) of Gene_expression (expression) of MMP-1
11) Confidence 0.28 Published 2005 Journal Rheumatology (Oxford) Section Body Doc Link 16148020 Disease Relevance 0 Pain Relevance 0
Rosiglitazone inhibited MMP-1 and MMP-13 expression in IL-1-?
Negative_regulation (inhibited) of Gene_expression (expression) of MMP-1
12) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2656243 Disease Relevance 0.13 Pain Relevance 0.10
ligand rosiglitazone and the RXR ligand LG268 specifically inhibit MMP-1 and MMP-13 gene expression in IL-1?
Negative_regulation (inhibit) of Gene_expression (expression) of MMP-1
13) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.40 Pain Relevance 0
leads to additive inhibition of MMP-1 and MMP-13 production, suggesting that these compounds could be used together, in lower doses than single-drug treatment, to reduce or block joint destruction in arthritis, thus minimizing the risk of adverse side effects.


Negative_regulation (inhibition) of Gene_expression (production) of MMP-1 in joint associated with arthritis
14) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.79 Pain Relevance 0.05
Rosiglitazone inhibits MMP-1 and MMP-13 gene expression in chondrocytic cells
Negative_regulation (inhibits) of Gene_expression (expression) of MMP-1
15) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.19 Pain Relevance 0.09
binding to the DR-1/AP-1 site in suppressing MMP-1 and MMP-13 production and addressed possible mechanisms of inhibition, including competitive binding between RXR:PPAR?
Negative_regulation (suppressing) of Gene_expression (production) of MMP-1
16) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.09 Pain Relevance 0.03
, ligands block MMP-1 and MMP-13 gene expression, RXR:PPAR?
Negative_regulation (block) of Gene_expression (expression) of MMP-1
17) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.15 Pain Relevance 0.04
heterodimer to the DR-1 element precludes binding of AP-1 proteins to its site and thereby antagonizes the expression of MMP-1.
Negative_regulation (antagonizes) of Gene_expression (expression) of MMP-1
18) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.33 Pain Relevance 0.14
Inhibition of MMP-1 expression was partially blocked by antibody to CD44, while it was not affected by antibody to ?
Negative_regulation (Inhibition) of Gene_expression (expression) of MMP-1
19) Confidence 0.23 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0 Pain Relevance 0
The effects on TIMP-1 and MMP-1 expression appeared to be mostly dependent on CD44, while the effect on MMP-7 expression was dependent on CD44 and integrin signaling.
Negative_regulation (dependent) of Gene_expression (expression) of MMP-1
20) Confidence 0.22 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.40 Pain Relevance 0.17

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