INT48238

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Context Info
Confidence 0.62
First Reported 1993
Last Reported 2011
Negated 1
Speculated 6
Reported most in Abstract
Documents 25
Total Number 31
Disease Relevance 11.48
Pain Relevance 16.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) extracellular region (Ngf)
Anatomy Link Frequency
nerve 17
primary sensory neurons 6
brain 4
skin 4
peripheral nervous system 4
Ngf (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 340 100.00 Very High Very High Very High
Inflammation 174 100.00 Very High Very High Very High
substance P 101 100.00 Very High Very High Very High
Pain 79 100.00 Very High Very High Very High
cytokine 65 100.00 Very High Very High Very High
Neuropeptide 63 100.00 Very High Very High Very High
nociceptor 8 99.96 Very High Very High Very High
adenocard 87 99.78 Very High Very High Very High
Enkephalin 4 99.70 Very High Very High Very High
sodium channel 10 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 203 100.00 Very High Very High Very High
Pain 56 100.00 Very High Very High Very High
Targeted Disruption 73 99.98 Very High Very High Very High
Bladder Disease 2 99.52 Very High Very High Very High
Herpes Simplex Virus 1 99.10 Very High Very High Very High
Neuropathic Pain 58 99.04 Very High Very High Very High
Ganglion Cysts 17 98.76 Very High Very High Very High
Diabetic Neuropathy 39 98.36 Very High Very High Very High
Cough 24 97.68 Very High Very High Very High
Nociception 20 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a Herpes simplex virus expression vector, we have investigated the effect of localized NGF expression in a genetic mouse model of progressive diabetic neuropathy, the +/+ Leprdb mouse.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of NGF associated with nerve growth factor, herpes simplex virus and diabetic neuropathy
1) Confidence 0.62 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16427624 Disease Relevance 0.82 Pain Relevance 0.67
Previous studies suggest that reproductive hormones may regulate the expression of NGF.
Spec (may) Regulation (regulate) of Gene_expression (expression) of NGF associated with nerve growth factor
2) Confidence 0.62 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882380 Disease Relevance 0.10 Pain Relevance 0.29
In this study we tested the hypothesis that neuropeptides released by cutaneous sensory nerves have the capacity to modulate directly the expression of keratinocyte nerve growth factor, which would have important implications for the maintenance and repair of nerves in the skin.
Regulation (modulate) of Gene_expression (expression) of nerve growth factor in nerve associated with nerve growth factor and neuropeptide
3) Confidence 0.52 Published 2001 Journal J. Invest. Dermatol. Section Abstract Doc Link 11710915 Disease Relevance 0 Pain Relevance 0.52
We report here that transgenic expression of NGF under control of the K14 keratin promoter can rescue some elements of the peripheral nervous system and restore normal growth and viability to ngf-/- mice.
Regulation (control) of Gene_expression (expression) of NGF in peripheral nervous system associated with targeted disruption and peripheral nervous system
4) Confidence 0.45 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15010204 Disease Relevance 0.40 Pain Relevance 0.13
Our results indicate that primary sensory neurons are responsive to NGF over-expression in the CNS.
Regulation (responsive) of Gene_expression (over) of NGF in primary sensory neurons associated with nerve growth factor
5) Confidence 0.45 Published 1995 Journal Eur. J. Neurosci. Section Abstract Doc Link 8542060 Disease Relevance 0.35 Pain Relevance 1.29
The aim of this study was to investigate the in vivo effects of CNS over-expression of nerve growth factor (NGF) on primary sensory neurons.
Spec (investigate) Regulation (effects) of Gene_expression (over) of NGF in primary sensory neurons associated with nerve growth factor
6) Confidence 0.45 Published 1995 Journal Eur. J. Neurosci. Section Abstract Doc Link 8542060 Disease Relevance 0.30 Pain Relevance 0.65
Comparison of the effect of oestradiol, tamoxifen and raloxifene on nerve growth factor-alpha expression in specific neonatal mouse uterine cell types using laser capture microdissection.
Regulation (effect) of Gene_expression (expression) of nerve growth factor in uterine associated with nerve growth factor
7) Confidence 0.45 Published 2003 Journal J. Mol. Endocrinol. Section Title Doc Link 12580757 Disease Relevance 0.17 Pain Relevance 0.45
The aim of this study was to investigate the in vivo effects of CNS over-expression of nerve growth factor (NGF) on primary sensory neurons.
Spec (investigate) Regulation (effects) of Gene_expression (over) of nerve growth factor in primary sensory neurons associated with nerve growth factor
8) Confidence 0.45 Published 1995 Journal Eur. J. Neurosci. Section Abstract Doc Link 8542060 Disease Relevance 0.30 Pain Relevance 0.62
M) and the change in NGF levels in NAL after provocation (p < 0.01, r = 0.7; Figure 2).
Regulation (change) of Gene_expression (levels) of NGF associated with nerve growth factor
9) Confidence 0.45 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257644 Disease Relevance 0.16 Pain Relevance 1.00
Thus, our current results support the current hypothesis that NGF-dependent neurons are primarily responsible for the development of allodynia.
Regulation (responsible) of Gene_expression (neurons) of NGF-dependent in neurons associated with allodynia and nerve growth factor
10) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.75 Pain Relevance 1.03
We are speculating that NGF production in the inflamed pancreas is responsible for plastic changes in the sensory neurons by activating proalgesic receptors and channels such as the NGF receptor tyrosine kinase A (TrkA) and Transient Receptor Potential Family V receptor 1 (TRPV1; previously known as VR1) thereby contributing to the generation of pain [24-26].
Regulation (responsible) of Gene_expression (production) of NGF in pancreas associated with pain
11) Confidence 0.39 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC554992 Disease Relevance 0.89 Pain Relevance 0.74
Excessive expression of inflammatory factors such as NGF and IL-6 in the bladder is considered to be responsible for the development and propagation of IC/PBS symptoms [32, 33].
Regulation (responsible) of Gene_expression (expression) of NGF in bladder associated with nerve growth factor and inflammation
12) Confidence 0.39 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2989383 Disease Relevance 0.94 Pain Relevance 0.25
In order to address this question experimentally we examined the effect of the neuropeptides, substance P and neurokinin A, on nerve growth factor expression in human keratinocytes and the murine keratinocyte PAM 212 cell line by quantitative reverse transcriptase-polymerase chain reaction, enzyme-linked immunosorbent assay, and the PC-12 nerve growth factor bioassay.
Spec (examined) Regulation (effect) of Gene_expression (expression) of nerve growth factor in nerve associated with nerve growth factor, neuropeptide and substance p
13) Confidence 0.38 Published 2001 Journal J. Invest. Dermatol. Section Abstract Doc Link 11710915 Disease Relevance 0 Pain Relevance 0.68
NGF receptors on mast cells act as autoreceptors, regulating mast cell NGF synthesis and release while at the same time being sensitive to NGF from the environment.
Regulation (regulating) of Gene_expression (synthesis) of NGF in mast cell associated with nerve growth factor
14) Confidence 0.37 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.30 Pain Relevance 0.74
Subsequent to NGF or BDNF exposure, no nuclear translocation of the NF-?
Regulation (Subsequent) of Gene_expression (exposure) of NGF
15) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0 Pain Relevance 0
Our data do not rule out the possibility of NGF or BDNF acting on gene expression in BMSC through one, or several, intermediate factors.
Neg (not) Spec (possibility) Regulation (acting) of Gene_expression (possibility) of NGF
16) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.86 Pain Relevance 0.27
Through microarray analysis we demonstrated that cytokine gene expression by BMSC changes in response to NGF or BDNF exposure (Figure 3A, B).
Regulation (response) of Gene_expression (exposure) of NGF associated with cytokine
17) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.35 Pain Relevance 0.09
Transgenic mice expressing nerve growth factor (NGF) under the control of a myelin basic protein promoter display above normal NGF levels in the spinal white matter from birth to the age of 2 months.
Regulation (under) of Gene_expression (expressing) of NGF in white matter associated with targeted disruption and nerve growth factor
18) Confidence 0.27 Published 2000 Journal Neuropeptides Section Abstract Doc Link 11049732 Disease Relevance 0.34 Pain Relevance 0.48
Transgenic mice that overexpress NGF under the keratin promoter (hyper-NGF mice) show increased levels of NGF in the skin from embryonic day 11 through adulthood, hypertrophy of the peripheral nervous system and mechanical hyperalgesia.
Regulation (under) of Gene_expression (overexpress) of NGF in peripheral nervous system associated with targeted disruption, hypertrophy, hyperalgesia, peripheral nervous system and nerve growth factor
19) Confidence 0.27 Published 1999 Journal J. Neurosci. Res. Section Abstract Doc Link 10397634 Disease Relevance 0.82 Pain Relevance 0.96
Altered expression of nerve growth factor in the skin of transgenic mice leads to changes in response to mechanical stimuli.
Regulation (Altered) of Gene_expression (expression) of nerve growth factor in skin associated with targeted disruption and nerve growth factor
20) Confidence 0.26 Published 1993 Journal Neuroscience Section Title Doc Link 7506820 Disease Relevance 0.55 Pain Relevance 0.49

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