INT48239

Context Info Confidence 0.33 First Reported 1993 Last Reported 2011 Negated 0 Speculated 3 Reported most in Body Documents 52 Total Number 55 Disease Relevance 23.14 Pain Relevance 6.45

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a) DNA binding (Gtf3a)

Anatomy Link Frequency plasma 2 liver 2 brain 2 nerve 2 sensory neurons 1 Gtf3a (Mus musculus)

Pain Link Frequency Relevance Heat mu opioid receptor 320 100.00 Nerve growth factor 52 100.00 Neuropeptide 11 100.00 rheumatoid arthritis 110 99.84 depression 22 99.60 neurotrophin 3 7 99.58 Inflammation 458 99.00 metalloproteinase 8 98.10 Infliximab 32 97.56 Glutamate receptor 18 97.36

Disease Link Frequency Relevance Heat Cancer 283 100.00 Necrosis 23 100.00 Rheumatoid Arthritis 111 99.84 Disease 618 99.80 Nicotine Addiction 13 99.80 Hypoxia 19 99.68 Hepatocellular Cancer 6 99.68 Depression 22 99.60 Nociception 2 99.24 Targeted Disruption 874 99.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Additionally, we assessed the effect of a monoclonal antibody that binds to and sequesters nerve growth factor (anti-NGF) on pain-related behaviors and bone healing (mechanical properties and histomorphometric analysis) after fracture.

factor Binding (binds) of in nerve

1) Confidence 0.33 Published 2007 Journal J. Bone Miner. Res. Section Body Doc Link 17638576 Disease Relevance 0 Pain Relevance 0

Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response.

factor Binding (Interaction) of associated with stress and neuropeptide

2) Confidence 0.10 Published 2004 Journal J. Neurosci. Section Title Doc Link 15601950 Disease Relevance 0.31 Pain Relevance 0.25

CONCLUSIONS: Laparotomy is associated with higher levels of a heparin-binding plasma factor, consistent with PDGF.

factor Binding (binding) of in plasma

3) Confidence 0.09 Published 2001 Journal Surg Endosc Section Body Doc Link 11443442 Disease Relevance 0 Pain Relevance 0

It has recently become clear that the neurotrophic factor, nerve growth factor, interacts specifically with nociceptive sensory neurons during development and maturity.

factor Spec (clear) Binding (interacts) of in sensory neurons associated with nociception and nerve growth factor

4) Confidence 0.08 Published 1993 Journal Neuroscience Section Abstract Doc Link 7506820 Disease Relevance 0.42 Pain Relevance 0.35

The phosphorylation of ERK was reduced by tyrphostin AG1478, an inhibitor of phosphorylation of the epidermal growth factor receptor (EGFR), and by heparin, which neutralizes heparin-binding epithelial growth factor (HB-EGF), suggesting the involvement of a transactivation process, in which alpha(2)-adrenergic stimulation leads to proteolytic shedding of HB-EGF (and perhaps other EGFR agonists) from transmembrane-spanning precursors.

factor Binding (heparin-binding) of associated with agonist

5) Confidence 0.04 Published 2003 Journal Brain Res. Section Abstract Doc Link 12834899 Disease Relevance 0 Pain Relevance 0.09

Sohn et al. showed that the ligation of a C3 complement activation factor (iC3b), which is constitutively present in aqueous humor, stimulates APC upregulation of IL-10 and TGF-?

factor Binding (ligation) of

6) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.24 Pain Relevance 0.17

The association between the risk factor and the disease may thus be easier to detect.

factor Binding (association) of associated with disease

7) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629547 Disease Relevance 1.26 Pain Relevance 0

0.04) and refrigerator exposure at birth was found to be a risk factor for CD (OR?

factor Binding (found) of associated with disease

8) Confidence 0.03 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2629547 Disease Relevance 0.82 Pain Relevance 0.16

Moreover, G-CSF is a pleiotropic factor that for example also impacts on immunocompetence and inflammatory reactions.

factor Binding (impacts) of associated with inflammation

9) Confidence 0.03 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 1.41 Pain Relevance 0.08

The potential for IL-9 to be a mast cell growth factor has been recognized in studies of IL-9 transgenic mice which have significantly increased levels of mast cells in various tissues including the lung (Godfraind et al. 2009; Temann et al. 1988).

factor Binding (recognized) of in mast cells associated with targeted disruption

10) Confidence 0.03 Published 2010 Journal Immunogenetics Section Body Doc Link PMC2910299 Disease Relevance 0.60 Pain Relevance 0.03

Administration of the neurotrophin nerve growth factor (NGF) to rats and humans has been shown to induce both thermal and mechanical hyperalgesia and is used as a model of inflammatory pain.

factor Binding (Administration) of in nerve associated with hyperalgesia, nerve growth factor and ipn

11) Confidence 0.02 Published 2006 Journal J Pain Section Abstract Doc Link 16414556 Disease Relevance 0.41 Pain Relevance 0.70

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family of growth factors that includes EGF, transforming growth factor (TGF)-?

factor Binding (binding) of

12) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.10 Pain Relevance 0

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family, serves as a neurotrophic molecular and plays a significant role in the brain.

factor Spec (like) Binding (binding) of in brain

13) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2759290 Disease Relevance 0.53 Pain Relevance 0.17

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family, serves as a neurotrophic molecular and plays a significant role in the brain.

factor Spec (like) Binding (binding) of in brain

14) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2759290 Disease Relevance 0.53 Pain Relevance 0.16

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family of growth factors that includes EGF, transforming growth factor (TGF)-?

factor Binding (binding) of

15) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.10 Pain Relevance 0

The polymorphism -260 T>C [dbSNP: rs2569190] has been shown to increase transcriptional activity by lowering the affinity of the GC box for Sp3, a factor known to inhibit the activity of a number of promoters.

factor Binding (affinity) of

16) Confidence 0.02 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1634873 Disease Relevance 0.66 Pain Relevance 0.30

A compatibility study showed that hTF can bind to murine Factor VIIa with high affinity to induce coagulation [35], while mTF binds poorly to human Factor VIIa [35], [36].

Factor Binding (binds) of

17) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 0.77 Pain Relevance 0.04

Circulating tumour necrosis factor-?

factor Binding (Circulating) of associated with necrosis and cancer

18) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1064892 Disease Relevance 0.82 Pain Relevance 0.35

A further example of the newly identified mouse liver protein is the hepatoma-derived growth factor (Swiss-Prot: P51859), e.g. a heparin-binding protein with mitogenic activity in fibroblasts.

factor Binding (binding) of in liver associated with hepatocellular cancer

19) Confidence 0.02 Published 2009 Journal Proteome Sci Section Body Doc Link PMC2752743 Disease Relevance 1.11 Pain Relevance 0

A wide range of molecular function gene ontology terms were overrepresented, the most significant of which were monooxygenase activity, heme binding, iron ion binding and insulin-like growth factor binding (P < 0.01).

factor Binding (binding) of

20) Confidence 0.02 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.35 Pain Relevance 0

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