INT48240

Context Info Confidence 0.46 First Reported 1993 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 46 Total Number 48 Disease Relevance 23.51 Pain Relevance 24.42

signal transduction (Ngf) extracellular space (Ngf) extracellular region (Ngf)

Anatomy Link Frequency nerve 13 neurons 5 sensory neurons 4 fibroblast 3 glial cell 2 Ngf (Mus musculus)

Pain Link Frequency Relevance Heat Nerve growth factor 687 100.00 Hyperalgesia 29 99.92 bDMF 22 99.92 substance P 30 99.68 dorsal root ganglion 40 99.42 Inflammation 76 99.40 nociceptor 23 99.38 c fibre 13 98.92 nav1.3 6 98.72 diabetic neuropathy 10 98.60

Disease Link Frequency Relevance Heat Disease 330 100.00 Cancer 244 100.00 Melanoma 102 100.00 Asthma 90 100.00 Hypersensitivity 64 100.00 Death 51 100.00 Wallerian Degeneration 12 100.00 Aging 20 99.98 Hyperalgesia 46 99.92 Salivary Gland Disease 36 99.90

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It has recently become clear that the neurotrophic factor, nerve growth factor, interacts specifically with nociceptive sensory neurons during development and maturity.

nerve growth factor Spec (clear) Binding (interacts) of in sensory neurons associated with nociception and nerve growth factor

1) Confidence 0.46 Published 1993 Journal Neuroscience Section Abstract Doc Link 7506820 Disease Relevance 0.42 Pain Relevance 0.35

Therefore, it is reasonable to propose that NGF secreted by melanoma tumor was transferred through blood and bound to its cognate receptors in the salivary gland, ultimately resulting in the stimulation of multiple TFs expression including Egr-1 (Fig. 6).

NGF Binding (bound) of in blood associated with nerve growth factor, cancer and melanoma

2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 1.33 Pain Relevance 0.40

Administration of the neurotrophin nerve growth factor (NGF) to rats and humans has been shown to induce both thermal and mechanical hyperalgesia and is used as a model of inflammatory pain.

NGF Binding (Administration) of in nerve associated with hyperalgesia, nerve growth factor and ipn

3) Confidence 0.37 Published 2006 Journal J Pain Section Abstract Doc Link 16414556 Disease Relevance 0.41 Pain Relevance 0.70

Local diminution of the neural growth factor (NGF) contributes to the apparition of diabetic neuropathy.

NGF Binding (diminution) of in neural associated with diabetic neuropathy

4) Confidence 0.37 Published 2008 Journal Transl Res Section Abstract Doc Link 18593635 Disease Relevance 0.61 Pain Relevance 0.16

To explore the mechanism involved in peripheral hypersensitivity during chronic infection, mice were infected with 60 cercariae of S. mansoni and injected 17 weeks later with nerve growth factor, anti-nerve growth factor or with other molecules known to be associated with hyperalgesic processes.

nerve growth factor Binding (associated) of in nerve associated with hyperalgesia, nerve growth factor, hypersensitivity and infection

5) Confidence 0.37 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9438678 Disease Relevance 0.81 Pain Relevance 0.55

CONCLUSIONS: E. coli LPS can stimulate increased NGF message and protein in the bladder.

NGF Binding (message) of in bladder

6) Confidence 0.37 Published 2001 Journal BJU Int. Section Body Doc Link 11350415 Disease Relevance 0.11 Pain Relevance 0

These findings support a role for keratinocyte-derived nerve growth factor via its action on sensory c-fibers, and subsequent release of neuropeptides to mediate mast cell degranulation in systemic suppression of contact hypersensitivity responses in mice following ultraviolet B exposure.

nerve growth factor Binding (role) of in nerve associated with c fibre, nerve growth factor, neuropeptide and contact dermatitis

7) Confidence 0.37 Published 2002 Journal J. Invest. Dermatol. Section Abstract Doc Link 11874476 Disease Relevance 0.62 Pain Relevance 0.73

The peptidergic population responds to nerve growth factor (NGF), while the nonpeptidergic DRG neurons postnatally switch their dependency from NGF to glial cell line-derived neurotrophic factor (GDNF).

nerve growth factor Binding (responds) of in glial cell associated with nerve growth factor

8) Confidence 0.37 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11161605 Disease Relevance 0.45 Pain Relevance 0.43

The peptidergic population responds to nerve growth factor (NGF), while the nonpeptidergic DRG neurons postnatally switch their dependency from NGF to glial cell line-derived neurotrophic factor (GDNF).

NGF Binding (responds) of in glial cell associated with nerve growth factor

9) Confidence 0.37 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11161605 Disease Relevance 0.45 Pain Relevance 0.43

BACKGROUND: Nerve growth factor (NGF) is elevated in allergic diseases such as bronchial asthma and can lead to an induction of substance P (SP) and related neuropeptides in guinea-pigs large-diameter, neurofilament-positive airway neurons.

NGF Binding (lead) of in neurons associated with asthma, nerve growth factor, hypersensitivity, neuropeptide, disease and substance p

10) Confidence 0.37 Published 2004 Journal Clin. Exp. Allergy Section Abstract Doc Link 15347383 Disease Relevance 0.30 Pain Relevance 0.30

BACKGROUND: Nerve growth factor (NGF) is elevated in allergic diseases such as bronchial asthma and can lead to an induction of substance P (SP) and related neuropeptides in guinea-pigs large-diameter, neurofilament-positive airway neurons.

Nerve growth factor Binding (lead) of in neurons associated with asthma, nerve growth factor, hypersensitivity, neuropeptide, disease and substance p

11) Confidence 0.37 Published 2004 Journal Clin. Exp. Allergy Section Abstract Doc Link 15347383 Disease Relevance 0.30 Pain Relevance 0.30

We examined the effect of electrical stimulation on the expression of Nav1.3, Nav1.8, and Nav1.9 by using cultured embryonic mouse sensory neurons under conditions in which nerve growth factor (NGF) was not limiting.

NGF Binding (limiting) of in nerve associated with nav1.3, nerve growth factor, nav1.8 and nav1.9

12) Confidence 0.36 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 14515348 Disease Relevance 0.22 Pain Relevance 1.33

We examined the effect of electrical stimulation on the expression of Nav1.3, Nav1.8, and Nav1.9 by using cultured embryonic mouse sensory neurons under conditions in which nerve growth factor (NGF) was not limiting.

nerve growth factor Binding (limiting) of in nerve associated with nav1.3, nerve growth factor, nav1.8 and nav1.9

13) Confidence 0.36 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 14515348 Disease Relevance 0.22 Pain Relevance 1.33

After washing, we added biotinylated goat antihuman NGF and allowed it to bind to the NGF.

NGF Binding (bind) of associated with nerve growth factor

14) Confidence 0.36 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257644 Disease Relevance 0.29 Pain Relevance 0.55

Nerve growth factor in standard and samples was bound to an anti-NGF mouse monoclonal antibody coated onto a BD Falcon 96-well microplate (BD Biosciences, Bedford, MA, USA).

Nerve growth factor Binding (bound) of in Nerve associated with nerve growth factor

15) Confidence 0.36 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257644 Disease Relevance 0.33 Pain Relevance 0.51

After washing, we added biotinylated goat antihuman NGF and allowed it to bind to the NGF.

NGF Binding (bind) of associated with nerve growth factor

16) Confidence 0.36 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257644 Disease Relevance 0.28 Pain Relevance 0.55

Mice deficient for nerve growth factor (NGF) and its high-affinity receptor, encoded by the trkA proto-oncogene, suffer from complete loss of sympathetic neurons and sensory neurons responsive to temperature and pain.

nerve growth factor Binding (deficient) of in sensory neurons associated with pain and nerve growth factor

17) Confidence 0.35 Published 1994 Journal FASEB J. Section Abstract Doc Link 8050673 Disease Relevance 0.23 Pain Relevance 0.14

Mice deficient for nerve growth factor (NGF) and its high-affinity receptor, encoded by the trkA proto-oncogene, suffer from complete loss of sympathetic neurons and sensory neurons responsive to temperature and pain.

NGF Binding (deficient) of in sensory neurons associated with pain and nerve growth factor

18) Confidence 0.35 Published 1994 Journal FASEB J. Section Abstract Doc Link 8050673 Disease Relevance 0.23 Pain Relevance 0.14

The signal for the sympathetic invasion of the DRG has not yet been shown, but associated with Wallerian degeneration is the upregulation of nerve growth factor (NGF) in the distal stump of the partially injured nerve, which may be retrograde-transported to the DRG in uninjured sensory axons to induce sprouting of sympathetic axons.

NGF Binding (associated) of in sympathetic associated with dorsal root ganglion, nerve growth factor and wallerian degeneration

19) Confidence 0.34 Published 1997 Journal Pain Section Abstract Doc Link 9272789 Disease Relevance 1.71 Pain Relevance 0.97

The signal for the sympathetic invasion of the DRG has not yet been shown, but associated with Wallerian degeneration is the upregulation of nerve growth factor (NGF) in the distal stump of the partially injured nerve, which may be retrograde-transported to the DRG in uninjured sensory axons to induce sprouting of sympathetic axons.

nerve growth factor Binding (associated) of in sympathetic associated with dorsal root ganglion, nerve growth factor and wallerian degeneration

20) Confidence 0.34 Published 1997 Journal Pain Section Abstract Doc Link 9272789 Disease Relevance 1.70 Pain Relevance 0.96

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