INT48244

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Context Info
Confidence 0.76
First Reported 1994
Last Reported 2011
Negated 3
Speculated 7
Reported most in Body
Documents 172
Total Number 179
Disease Relevance 132.38
Pain Relevance 73.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
T cells 15
plasma 7
lymphocytes 6
mononuclear cell 5
blood 5
Il4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1598 100.00 Very High Very High Very High
cytokine 1532 100.00 Very High Very High Very High
Inflammatory mediators 100 100.00 Very High Very High Very High
chemokine 85 100.00 Very High Very High Very High
gABA 61 100.00 Very High Very High Very High
Enkephalin 45 100.00 Very High Very High Very High
dorsal root ganglion 506 99.92 Very High Very High Very High
Arthritis 242 99.92 Very High Very High Very High
Sciatic nerve 5 99.84 Very High Very High Very High
Neuritis 70 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1778 100.00 Very High Very High Very High
Cancer 293 100.00 Very High Very High Very High
Necrosis 125 100.00 Very High Very High Very High
Adhesions 46 100.00 Very High Very High Very High
Cytomegalovirus Infection 45 100.00 Very High Very High Very High
Cold Sores 484 99.96 Very High Very High Very High
Ganglion Cysts 532 99.92 Very High Very High Very High
Arthritis 222 99.92 Very High Very High Very High
Hypersensitivity 220 99.80 Very High Very High Very High
Syndrome 86 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In DBTC-treated rats, adenovirus-mediated transfer of the IL-4 gene modified the pattern of infiltrating inflammatory cells in the pancreas.
Gene_expression (transfer) of IL-4 in pancreas
1) Confidence 0.76 Published 2005 Journal Scand. J. Gastroenterol. Section Body Doc Link 16165721 Disease Relevance 0 Pain Relevance 0
Expression of beta-Gal and IL-4 in pancreatic cells was analyzed by X-Gal staining and reverse transcriptase-polymerase chain reaction (RT-PCR), respectively.
Spec (analyzed) Gene_expression (Expression) of IL-4
2) Confidence 0.76 Published 2005 Journal Scand. J. Gastroenterol. Section Body Doc Link 16165721 Disease Relevance 0 Pain Relevance 0
RT-PCR analysis using RNA from pancreata of AdrIL-4-treated rats indicated that IL-4 was expressed for at least 14 days after adenovirus application.
Gene_expression (expressed) of IL-4
3) Confidence 0.76 Published 2005 Journal Scand. J. Gastroenterol. Section Body Doc Link 16165721 Disease Relevance 0 Pain Relevance 0
Expression of the IL-4 transgene was accompanied by a transient increase of the IL-10 mRNA level in the pancreas.
Gene_expression (Expression) of IL-4 in pancreas
4) Confidence 0.76 Published 2005 Journal Scand. J. Gastroenterol. Section Body Doc Link 16165721 Disease Relevance 0 Pain Relevance 0
Exposure to these analgesics was associated with a differential suppression of interleukin-4 production by T-cells, as well as a more generalized suppression of cytokine production by macrophages.
Gene_expression (production) of interleukin-4 in macrophages associated with analgesic and cytokine
5) Confidence 0.73 Published 1995 Journal Immunol. Lett. Section Abstract Doc Link 7590906 Disease Relevance 0 Pain Relevance 0.30
In this study, we investigated mucosal expression of ET-1, interleukin-4 (IL-4), and the activity of constitutive nitric oxide synthase (cNOS) during indomethacin-induced gastric mucosal injury, and evaluated the effect of antiulcer agents on this process.
Spec (investigated) Gene_expression (expression) of IL-4 associated with injury
6) Confidence 0.69 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10424717 Disease Relevance 0.42 Pain Relevance 0.10
Pretreatment with H2-receptor antagonist, ranitidine produced a 15.7% reduction in the mucosal damage caused by indomethacin, 29.5% decrease in epithelial cell apoptosis and a 19.6% reduction in ET-1, while the expression of IL-4 increased by 10.8% and that of cNOS showed a 2-fold increase.
Gene_expression (expression) of IL-4 in epithelial cell associated with antagonist and apoptosis
7) Confidence 0.69 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10424717 Disease Relevance 0.65 Pain Relevance 0.10
In this study, we investigated mucosal expression of ET-1, interleukin-4 (IL-4), and the activity of constitutive nitric oxide synthase (cNOS) during indomethacin-induced gastric mucosal injury, and evaluated the effect of antiulcer agents on this process.
Spec (investigated) Gene_expression (expression) of interleukin-4 associated with injury
8) Confidence 0.69 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10424717 Disease Relevance 0.42 Pain Relevance 0.10
MATERIAL AND METHODS: Recombinant adenovirus constructs carrying the Escherichia coli beta-galactosidase gene (Adbeta-gal) or the rat IL-4 gene (AdrIL-4) were injected into the left gastric artery of healthy LEW.1W rats.
Gene_expression (carrying) of IL-4 in gastric artery
9) Confidence 0.66 Published 2005 Journal Scand. J. Gastroenterol. Section Body Doc Link 16165721 Disease Relevance 0 Pain Relevance 0
Expression of IL-4 in vitro
Gene_expression (Expression) of IL-4
10) Confidence 0.63 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 0.94 Pain Relevance 0.44
Vector-mediated IL-4 expression also reduced thermal hyperalgesia.
Gene_expression (expression) of IL-4 associated with thermal hyperalgesia
11) Confidence 0.63 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 0.49 Pain Relevance 0.69
IL-4 produced by subcutaneous inoculation of S4IL4 suppressed expression of p-p38 but not pERK in the dorsal horn.
Gene_expression (produced) of IL-4 in dorsal horn associated with dorsal horn
12) Confidence 0.63 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 1.12 Pain Relevance 1.10
Previous studies have suggested that proinflammatory cytokines may play a role in the initiation of neuropathic pain [3-6]; therefore, we were interested to determine whether expression of IL-4 prior to the time of spinal nerve injury would prevent the development of neuropathic pain.
Gene_expression (expression) of IL-4 in spinal nerve associated with nervous system injury, neuropathic pain and cytokine
13) Confidence 0.63 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 0.71 Pain Relevance 0.85
IL-4 produced in the DRG is transported both centrally (towards the spinal cord) and peripherally (towards the skin) in the bipolar axon of the sensory neuron, and the experiments performed do not allow us to distinguish the effects of IL-4 in the nerve from effects that occur at the level of the spinal cord.
Gene_expression (produced) of IL-4 in spinal cord associated with dorsal root ganglion and spinal cord
14) Confidence 0.63 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 1.02 Pain Relevance 0.88
Construction of the IL-4-expressing HSV vector
Gene_expression (expressing) of IL-4 associated with cold sores
15) Confidence 0.63 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 1.47 Pain Relevance 0.89
In the experiments that are the subject of the current report, we have demonstrated that transgene-mediated expression of IL-4 in DRG effectively reduces nocifensive behaviors and blocks expression of IL-1?
Gene_expression (expression) of IL-4 associated with dorsal root ganglion
16) Confidence 0.63 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 1.31 Pain Relevance 1.22
Vector-mediated IL-4 production did not affect normal sensory function.
Gene_expression (production) of IL-4
17) Confidence 0.63 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 1.00 Pain Relevance 0.76
Interleukin-4 gene transfer into rat pancreas by recombinant adenovirus.
Gene_expression (transfer) of Interleukin-4 gene in pancreas
18) Confidence 0.59 Published 2005 Journal Scand. J. Gastroenterol. Section Title Doc Link 16165721 Disease Relevance 0.36 Pain Relevance 0.22
After optimization of the transduction protocol, effects of the IL-4 gene transfer on pancreatic inflammation and fibrosis were studied in DBTC-treated rats.
Gene_expression (transfer) of IL-4
19) Confidence 0.59 Published 2005 Journal Scand. J. Gastroenterol. Section Body Doc Link 16165721 Disease Relevance 0 Pain Relevance 0
This study examines the alterations in serum levels of TGF-beta and IL-4 after a thermal injury.
Gene_expression (levels) of IL-4 associated with injury
20) Confidence 0.58 Published 2001 Journal Shock Section Abstract Doc Link 11699077 Disease Relevance 0.71 Pain Relevance 0.13

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