INT48246

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Context Info
Confidence 0.64
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 10.33
Pain Relevance 4.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PLP1) structural molecule activity (PLP1)
Anatomy Link Frequency
uterus 1
CSF 1
optic 1
T cells 1
PLP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 19 100.00 Very High Very High Very High
intrathecal 3 99.98 Very High Very High Very High
Multiple sclerosis 21 98.32 Very High Very High Very High
Neuritis 25 97.56 Very High Very High Very High
headache 1 94.88 High High
nerve block 237 92.28 High High
cytokine 6 90.16 High High
Lasting pain 7 89.80 High High
Inflammation 16 89.72 High High
anesthesia 12 80.00 Quite High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 17 99.84 Very High Very High Very High
Togavirus Infection 6 98.96 Very High Very High Very High
Demyelinating Disease 35 98.32 Very High Very High Very High
Cancer 56 97.88 Very High Very High Very High
Optic Neuritis 24 97.80 Very High Very High Very High
Fever 1 95.16 Very High Very High Very High
Neurological Disease 2 95.08 Very High Very High Very High
Headache 1 94.88 High High
Hypoxia 10 93.60 High High
Uterine Fibroids 144 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[A case report of subacute panencephalitis associated with specific T cells sensitized to proteolipid protein (PLP) synthetic peptides identified with rubella virus].
Gene_expression (synthetic) of proteolipid protein in T cells associated with togavirus infection
1) Confidence 0.64 Published 1996 Journal Rinsho Shinkeigaku Section Title Doc Link 8976131 Disease Relevance 1.20 Pain Relevance 0.12
We have shown that the sensation of movement evoked by rTMS when applied over PMd is not affected by the absence of sensory feedback, to the same degree as when applied over M1, suggesting that a corollary discharge evoked by TMS over PMd induces sensation of movement.


Gene_expression (applied) of PMd
2) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952623 Disease Relevance 0 Pain Relevance 0.47
However, when the M1 stimulation intensity was reduced in control experiment 1 (see supplementary Text S1's Supplementary control experiment section and supplementary Figure S1) such that the induced sensation was similar to the sensation of movement induced over PMd, we found that even intermediate (subjective scale ?
Gene_expression (over) of PMd
3) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952623 Disease Relevance 0 Pain Relevance 0.29
Finally, Desmurget et al. used 4 s stimulation trains where we only produced sensations of movement over M1 and PMd with 500 ms trains.
Gene_expression (produced) of PMd
4) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952623 Disease Relevance 0.09 Pain Relevance 0
Nearly 90% of patients in our program had a PMD prior to enrollment in case management, and nearly 90% had health insurance prior to enrollment.
Gene_expression (management) of PMD
5) Confidence 0.38 Published 2010 Journal Western Journal of Emergency Medicine Section Body Doc Link PMC2967685 Disease Relevance 0.29 Pain Relevance 0.19
It has been well established that steroid hormones such as estrogen and progesterone regulate the expression of myelin proteins such as proteolipid protein (reviewed in [57]).
Gene_expression (expression) of proteolipid protein
6) Confidence 0.32 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 1.01 Pain Relevance 0.05
To study the immunological mechanisms causing axonal degeneration, we induced experimental autoimmune encephalomyelitis (EAE) in wildtype Lewis rats and Lewis rats with a slowly progressive myelin degeneration due to proteolipid protein (PLP) overexpression.
Gene_expression (overexpression) of PLP associated with multiple sclerosis
7) Confidence 0.32 Published 2006 Journal Acta Neuropathol. Section Abstract Doc Link 16718350 Disease Relevance 1.22 Pain Relevance 0.20
To study the immunological mechanisms causing axonal degeneration, we induced experimental autoimmune encephalomyelitis (EAE) in wildtype Lewis rats and Lewis rats with a slowly progressive myelin degeneration due to proteolipid protein (PLP) overexpression.
Gene_expression (overexpression) of proteolipid protein associated with multiple sclerosis
8) Confidence 0.32 Published 2006 Journal Acta Neuropathol. Section Abstract Doc Link 16718350 Disease Relevance 1.22 Pain Relevance 0.20
It is worthwhile to note that directions of expression changes of ANXA1, NR4A1 and PLP1 were opposite from that of the estrogen treated rat uterus.
Gene_expression (expression) of PLP1 in uterus
9) Confidence 0.29 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.84 Pain Relevance 0.04
RNAi knockdown experiments of MRF in cultured oligodendrocytic cells were found to prevent expression of many important CNS myelin genes, including CNPase, PLP, MAG, and MOBP.
Gene_expression (expression) of PLP associated with central nervous system
10) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864763 Disease Relevance 0.07 Pain Relevance 0.10
In both monkeys, one array was implanted in M1 and one in PMd.
Gene_expression (one) of PMd
11) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3006173 Disease Relevance 0.06 Pain Relevance 0.18
Decoding in M1 and PMd
Gene_expression (Decoding) of PMd
12) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3006173 Disease Relevance 0.05 Pain Relevance 0
Using an in situ hybridization technique that gives high resolution and is very sensitive, we examined myelin basic protein and proteolipid protein gene expression three and twenty-four hours after a H-I insult.
Gene_expression (expression) of proteolipid protein
13) Confidence 0.14 Published 2001 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 11255033 Disease Relevance 0.88 Pain Relevance 0.08
Interestingly, some cells in the subventricular layer expressed proteolipid protein transcripts, and 3 h after a H--I insult they were degenerating in the injured but not contralateral side.
Gene_expression (expressed) of proteolipid protein
14) Confidence 0.10 Published 2001 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 11255033 Disease Relevance 0.71 Pain Relevance 0.05
There were elevated levels of cells that in response to MBP and PLP expressed IFN-gamma, IL-4 and TGF-beta mRNA in blood and further enriched in CSF in both ON and MS, compared to patients with other neurological diseases.
Gene_expression (expressed) of PLP in CSF associated with multiple sclerosis, neurological disease and neuritis
15) Confidence 0.09 Published 1994 Journal J. Neuroimmunol. Section Abstract Doc Link 7507500 Disease Relevance 0.94 Pain Relevance 1.09
OBJECTIVE: To study the intrathecal synthesis of anti-myelin basic protein (MBP) and anti-proteolipid protein (PLP) antibodies in patients in the early stages of multiple sclerosis.
Gene_expression (synthesis) of anti-proteolipid protein associated with multiple sclerosis and intrathecal
16) Confidence 0.09 Published 1994 Journal Arch. Neurol. Section Abstract Doc Link 7524468 Disease Relevance 0.17 Pain Relevance 0.17
and proteolipid protein (PLP), are not differentially expressed in the
Neg (not) Gene_expression (expressed) of proteolipid protein
17) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2581793 Disease Relevance 0.05 Pain Relevance 0.03
The results demonstrate a potential for intrathecal synthesis of both anti-myelin basic protein and anti-proteolipid protein antibodies of high apparent affinity in patients with optic neuritis.
Gene_expression (synthesis) of anti-proteolipid protein in optic associated with optic neuritis, neuritis and intrathecal
18) Confidence 0.01 Published 1995 Journal Ann. Neurol. Section Abstract Doc Link 8526468 Disease Relevance 0.79 Pain Relevance 0.72
Presence of the multiple sclerosis-associated DRB1*1501 gene was not associated with preferential synthesis of high-affinity antibodies reactive with a single myelin basic protein peptide or with preferential synthesis of either anti-myelin basic protein or anti-proteolipid protein antibodies.
Gene_expression (synthesis) of anti-proteolipid protein associated with multiple sclerosis
19) Confidence 0.01 Published 1995 Journal Ann. Neurol. Section Abstract Doc Link 8526468 Disease Relevance 0.74 Pain Relevance 0.74

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