INT48248

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 38
Total Number 42
Disease Relevance 19.30
Pain Relevance 25.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Scn10a) transmembrane transport (Scn10a)
Anatomy Link Frequency
dorsal root ganglia 9
trigeminal ganglion 4
ND7/23 3
sciatic nerve 3
neurons 3
Scn10a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 117 100.00 Very High Very High Very High
Peripheral nerve injury 84 100.00 Very High Very High Very High
Neuropeptide 43 100.00 Very High Very High Very High
dorsal root ganglion 34 100.00 Very High Very High Very High
nav1.8 15 100.00 Very High Very High Very High
Calcium channel 1 100.00 Very High Very High Very High
c fibre 132 99.96 Very High Very High Very High
Eae 94 99.92 Very High Very High Very High
Nerve growth factor 4 99.78 Very High Very High Very High
Nav1.9 15 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 198 100.00 Very High Very High Very High
Ganglion Cysts 52 100.00 Very High Very High Very High
Injury 181 99.92 Very High Very High Very High
Nociception 13 99.64 Very High Very High Very High
INFLAMMATION 15 98.12 Very High Very High Very High
Neuropathic Pain 56 98.06 Very High Very High Very High
Hyperalgesia 1 97.60 Very High Very High Very High
Pain 40 96.96 Very High Very High Very High
Arthralgia 6 95.72 Very High Very High Very High
Disease 3 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PN3 mRNA was not detected in sections of brain and spinal cord taken from either normal or nerve-injured rats. (3) In contrast, immunohistochemical studies showed that major changes in the subcellular distribution of PN3 protein were caused by either CCI or complete transection of the sciatic nerve.
Neg (not) Gene_expression (detected) of PN3 mRNA in spinal cord associated with eae, sciatic nerve and spinal cord
1) Confidence 0.78 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9482802 Disease Relevance 1.05 Pain Relevance 0.89
To assess further the role of PN3, we have used electrophysiological, in situ hybridization and immunohistochemical methods to monitor changes in TTXR sodium current and the distribution of PN3 in normal and peripheral nerve-injured rats. (1) Whole-cell patch-clamp recordings showed that there were no significant changes in the TTXR and TTX-sensitive sodium current densities of small DRG neurons after chronic constriction injury (CCI) of the sciatic nerve. (2) Additionally, in situ hybridization showed that there was no change in the expression of PN3 mRNA in the DRG up to 14 d after CCI.
Gene_expression (expression) of PN3 mRNA in sciatic nerve associated with dorsal root ganglion, eae, injury and sciatic nerve
2) Confidence 0.78 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9482802 Disease Relevance 0.99 Pain Relevance 0.89
In situ hybridization to rat DRG indicated that PN3 is expressed primarily in small sensory neurons of the peripheral nervous system.
Gene_expression (expressed) of PN3 in DRG associated with peripheral nervous system and sodium channel
3) Confidence 0.78 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8626372 Disease Relevance 0.08 Pain Relevance 0.58
Previous work has revealed acute administration of inflammatory mediators, such as Freund's complete adjuvant (FCA) or carrageenan caused an upregulation in the levels of Na(V)1.7 and Na(V)1.8 protein in DRG (dorsal root ganglia) tissue up to 4 days post-insult.
Gene_expression (levels) of Na(V)1.8 in dorsal root ganglia associated with inflammatory mediators
4) Confidence 0.75 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17950013 Disease Relevance 0.59 Pain Relevance 0.66
Expression of both Na(v)1.8 and Na(v)1.9 increases with age, beginning at embryonic day (E) 15 and E17, respectively, and reaching adult levels by postnatal day 7.
Gene_expression (Expression) of Na(v)1.8
5) Confidence 0.75 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11487631 Disease Relevance 0 Pain Relevance 0.83
The present study investigated the effect of inhibiting the expression of Na(v)1.8 (PN3/SNS) sodium channels by an antisense oligodeoxynucleotide (ODN) on bladder nociceptive responses induced by intravesical acetic acid infusion in rats.
Gene_expression (expression) of PN3 in bladder associated with nociception and sodium channel
6) Confidence 0.75 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11606657 Disease Relevance 0.16 Pain Relevance 0.32
The present study investigated the effect of inhibiting the expression of Na(v)1.8 (PN3/SNS) sodium channels by an antisense oligodeoxynucleotide (ODN) on bladder nociceptive responses induced by intravesical acetic acid infusion in rats.
Gene_expression (expression) of Na(v)1.8 in bladder associated with nociception and sodium channel
7) Confidence 0.75 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11606657 Disease Relevance 0.16 Pain Relevance 0.31
This suggests that other regulatory proteins are required for normal levels of Na(V)1.8 expression.
Gene_expression (expression) of Na(V)1.8
8) Confidence 0.75 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12591166 Disease Relevance 0.18 Pain Relevance 0.48
In the present study, the expression of Na(V)1.7, Na(V)1.8 and Na(V)1.9 was examined over a 28 day timecourse during a rat model of FCA-induced chronic inflammatory joint pain.
Spec (examined) Gene_expression (expression) of Na(V)1.8 in joint associated with pain, arthralgia and inflammation
9) Confidence 0.75 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17950013 Disease Relevance 0.60 Pain Relevance 0.68
Using Northern blot analysis and membrane potential measurement, several siRNAs were identified that were capable of a highly-selective attenuation of Na(V)1.8 message as well as functional expression in clonal ND7/23 cells which were stably transfected with the rat Na(V)1.8 gene.
Gene_expression (expression) of Na(V)1.8 in ND7/23
10) Confidence 0.75 Published 2007 Journal Neuroscience Section Abstract Doc Link 17367951 Disease Relevance 0.52 Pain Relevance 0.60
Na(v)1.8 is expressed in a higher proportion of neuronal profiles than Na(v)1.9 at all stages during development, as in the adult.
Gene_expression (expressed) of Na(v)1.8 in neuronal
11) Confidence 0.75 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11487631 Disease Relevance 0 Pain Relevance 0.81
The differential expression of Na(v)1.8 and Na(v)1.9 in late embryonic development, with their distinctive kinetic properties, may contribute to the development of spontaneous and stimulus-evoked excitability in small diameter primary sensory neurons in the perinatal period and the activity-dependent changes in differentiation they produce.
Gene_expression (expression) of Na(v)1.8 in primary sensory neurons
12) Confidence 0.75 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11487631 Disease Relevance 0 Pain Relevance 0.64
Tetrodotoxin-resistant (TTX-R) sodium channels Na(v)1.8/SNS and Na(v)1.9/NaN are preferentially expressed in small diameter dorsal root ganglia (DRG) neurons.
Gene_expression (expressed) of Na(v)1.9/NaN in dorsal root ganglia associated with tetrodotoxin and sodium channel
13) Confidence 0.73 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560118 Disease Relevance 0 Pain Relevance 0.38
The novel sodium channel PN3/alpha-SNS, which was cloned from a rat dorsal root ganglion (DRG) cDNA library, is expressed predominantly in small sensory neurons and may contribute to the tetrodotoxin-resistant (TTXR) sodium current that is believed to be associated with central sensitization in chronic neuropathic pain states.
Gene_expression (expressed) of PN3 in dorsal root ganglion associated with ganglion cysts, tetrodotoxin, dorsal root ganglion, central sensitization, neuropathic pain and sodium channel
14) Confidence 0.68 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9482802 Disease Relevance 0.42 Pain Relevance 0.55
The alteration in immunolabeling was attributed to translocation of presynthesized, intracellularly located PN3 protein from neuronal somata to peripheral axons, with subsequent accumulation at the site of injury.
Gene_expression (presynthesized) of PN3 protein in neuronal associated with injury
15) Confidence 0.68 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9482802 Disease Relevance 0.89 Pain Relevance 0.87
[Expression of PN3 and NaN in trigeminal ganglion during occlusal trauma in rat].
Gene_expression (Expression) of PN3 in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion and injury
16) Confidence 0.67 Published 2004 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Title Doc Link 15498355 Disease Relevance 0.20 Pain Relevance 0.19
These results indicate that the basic kinetic properties of mEPSCs are present by PN 3-5 and do not change significantly over the first two postnatal weeks.
Gene_expression (present) of PN 3
17) Confidence 0.65 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 7507519 Disease Relevance 0.08 Pain Relevance 0.24
The siRNA, which was delivered to lumbar dorsal root ganglia (DRG) via an indwelling epidural cannula, caused a significant reduction of Na(V)1.8 mRNA expression in lumbar 4 and 5 (L4-L5) DRG neurons and consequently reversed mechanical allodynia in CCI rats.
Gene_expression (expression) of Na(V)1.8 in dorsal root ganglia associated with allodynia, injury and epidural
18) Confidence 0.65 Published 2007 Journal Neuroscience Section Abstract Doc Link 17367951 Disease Relevance 0.74 Pain Relevance 0.66
Using Northern blot analysis and membrane potential measurement, several siRNAs were identified that were capable of a highly-selective attenuation of Na(V)1.8 message as well as functional expression in clonal ND7/23 cells which were stably transfected with the rat Na(V)1.8 gene.
Gene_expression (transfected) of Na(V)1.8 in ND7/23
19) Confidence 0.65 Published 2007 Journal Neuroscience Section Abstract Doc Link 17367951 Disease Relevance 0.64 Pain Relevance 0.65
Tetrodotoxin-resistant (TTX-R) sodium channels Na(v)1.8/SNS and Na(v)1.9/NaN are preferentially expressed in small diameter dorsal root ganglia (DRG) neurons.
Gene_expression (expressed) of Na(v)1.9/NaN in dorsal root ganglia associated with tetrodotoxin and sodium channel
20) Confidence 0.63 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560118 Disease Relevance 0 Pain Relevance 0.38

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