INT48250

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Context Info
Confidence 0.29
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.47
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rara) nucleus (Rara) enzyme binding (Rara)
DNA binding (Rara) transcription factor binding (Rara) cytoplasm (Rara)
Anatomy Link Frequency
lung 1
Rara (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 11 98.84 Very High Very High Very High
antagonist 2 97.64 Very High Very High Very High
agonist 1 90.76 High High
Inflammatory response 36 84.08 Quite High
dexamethasone 122 82.16 Quite High
Inflammation 41 58.92 Quite High
alcohol 4 47.20 Quite Low
qutenza 1 25.00 Low Low
corticosteroid 8 12.56 Low Low
cytokine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 16 99.76 Very High Very High Very High
Stress 2 96.88 Very High Very High Very High
Disease 3 94.72 High High
Hypersensitivity 2 94.36 High High
Asthma 2 93.80 High High
Autoimmune Disease 2 93.48 High High
Lung Cancer 14 85.64 High High
INFLAMMATION 77 83.72 Quite High
Rheumatoid Arthritis 128 81.68 Quite High
Nicotine Addiction 30 80.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is also evidence that BC supplementation can result in a changed regulation of the transcription factor retinoic acid receptor (RAR) [15].
Regulation (regulation) of RAR
1) Confidence 0.29 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2877315 Disease Relevance 0.91 Pain Relevance 0
However, the ammonia-induced RAR stimulation was not significantly altered by prior treatment with the SP blocker (300 and 500 micrograms/kg).
Neg (not) Regulation (altered) of RAR associated with substance p
2) Confidence 0.25 Published 1994 Journal Lung Section Abstract Doc Link 7507541 Disease Relevance 0 Pain Relevance 0.53
Interestingly, interferon-stimulated genes, which were predominant in our study, can also be RAR-regulated [37, 38].
Regulation (regulated) of RAR
3) Confidence 0.13 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2877315 Disease Relevance 0.84 Pain Relevance 0.17
On the other hand, impaired distal airspace formation during postnatal lung development has also been reported in RAR-?
Regulation (reported) of RAR in lung
4) Confidence 0.04 Published 2006 Journal Respir Res Section Body Doc Link PMC1448204 Disease Relevance 0.72 Pain Relevance 0.13

General Comments

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