INT48253

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.86
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AMY2A) small molecule metabolic process (AMY2A) hydrolase activity, acting on glycosyl bonds (AMY2A)
extracellular region (AMY2A) carbohydrate metabolic process (AMY2A)
Anatomy Link Frequency
sympathetic 1
PFC 1
AMY2A (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 3 95.68 Very High Very High Very High
Pain 12 92.04 High High
Dopamine 80 90.76 High High
Chronic pancreatitis 18 89.76 High High
nMDA receptor 3 86.20 High High
Pyramidal cell 12 80.88 Quite High
Snapping jaw 2 76.44 Quite High
agonist 14 75.60 Quite High
Lasting pain 1 75.00 Quite High
Pain scale 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Stress 9 99.96 Very High Very High Very High
Adenocarcinoma 31 99.84 Very High Very High Very High
Pancreatitis 29 97.80 Very High Very High Very High
Abdominal Pain 3 95.68 Very High Very High Very High
Pain 9 92.04 High High
Disease 3 78.64 Quite High
Attention Deficit Hyperactivity Disorder 36 78.24 Quite High
Temporomandibular Joint Syndrome 2 76.44 Quite High
Hyperamylasemia 2 75.00 Quite High
Calcification 1 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous reports suggest that elevated salivary alpha-amylase may reflect increased physical stress.
Positive_regulation (elevated) of alpha-amylase associated with stress
1) Confidence 0.59 Published 2007 Journal Reg Anesth Pain Med Section Abstract Doc Link 17350522 Disease Relevance 0.34 Pain Relevance 0.24
Since there are positive correlations between salivary alpha-amylase secretion and sympathetic parameter increment during stress, salivary alpha-amylase might be an indicator of sympathetic-adrenal-medullary (SAM) system and central sympathetic activity In contrast, it is well known that sympathetic neural activity is significantly involved in development and deterioration of pain symptoms as a part of pain disorders.
Positive_regulation (salivary) of alpha-amylase in sympathetic associated with stress and pain
2) Confidence 0.42 Published 2009 Journal Masui Section Abstract Doc Link 19928502 Disease Relevance 0.52 Pain Relevance 0.39
Increasing the concentration of alpha-amylase significantly decreased its viscoelasticity.
Positive_regulation (Increasing) of alpha-amylase
3) Confidence 0.37 Published 2003 Journal Journal of biomedical materials research. Part A Section Abstract Doc Link 12746886 Disease Relevance 0.15 Pain Relevance 0.15
Elevated alpha-amylase activity in serum was thought for a long time to be a laboratory standard in diagnosis of acute pancreatic disease.
Positive_regulation (Elevated) of alpha-amylase associated with pancreatitis
4) Confidence 0.13 Published 1993 Journal Cesk Pediatr Section Abstract Doc Link 7507802 Disease Relevance 0.31 Pain Relevance 0.07
In previous laboratory measurements using Spofa test (Slovakofarma) they were found to have elevated alpha-amylase in serum, thus the pancreatic disorder was put in question.
Positive_regulation (elevated) of alpha-amylase
5) Confidence 0.13 Published 1993 Journal Cesk Pediatr Section Abstract Doc Link 7507802 Disease Relevance 0.33 Pain Relevance 0.09
In this study we determined the clinical accuracy of alpha2-macroglobulin, alpha-amylase, C-reactive protein, lipase, non-esterified fatty acids, pancreatic alpha-amylase and phospholipase A in the diagnosis and prognosis of acute pancreatitis in a group of patients with acute abdominal pain using receiver operator characteristic curve analysis.
Positive_regulation (pancreatic) of alpha-amylase associated with abdominal pain and pancreatitis
6) Confidence 0.10 Published 2000 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 11156345 Disease Relevance 0.43 Pain Relevance 0.10
This analysis revealed a significant increase in the mRNA ratio of BGLAP/Amy2A in PDAC (p < 0.0001) compared to normal pancreatic tissues.
Positive_regulation (increase) of Amy2A associated with adenocarcinoma
7) Confidence 0.07 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.63 Pain Relevance 0.39
Arnsten and Dudley [66] have shown that the PFC-enhancing effects of methylphenidate are prevented by blockade of either NE alpha-2 or DAD1 receptors, suggesting that stimulants facilitate endogenous stimulation of D1 and alpha-2A receptors in the PFC.
Positive_regulation (stimulation) of alpha-2A in PFC
8) Confidence 0.05 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.15 Pain Relevance 0.35

General Comments

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