INT48257

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Context Info
Confidence 0.41
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 7.82
Pain Relevance 8.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (P2rx7) mitochondrion organization (P2rx7) protein complex (P2rx7)
transmembrane transport (P2rx7) cytoplasm (P2rx7) cell death (P2rx7)
Anatomy Link Frequency
paw 1
nerve 1
brain 1
IB4 1
hearts 1
P2rx7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 176 100.00 Very High Very High Very High
substance P 20 100.00 Very High Very High Very High
agonist 50 99.98 Very High Very High Very High
Inflammation 156 99.96 Very High Very High Very High
Potency 124 99.96 Very High Very High Very High
potassium channel 48 99.70 Very High Very High Very High
Antinociceptive 29 99.28 Very High Very High Very High
IPN 22 99.22 Very High Very High Very High
Pain 89 98.68 Very High Very High Very High
Analgesic 6 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 179 99.96 Very High Very High Very High
Neuropathic Pain 168 99.28 Very High Very High Very High
Inflammatory Pain 40 99.22 Very High Very High Very High
Injury 129 99.00 Very High Very High Very High
Hypersensitivity 8 98.80 Very High Very High Very High
Pain 95 98.40 Very High Very High Very High
Ganglion Cysts 12 97.88 Very High Very High Very High
Cv Unclassified Under Development 10 96.10 Very High Very High Very High
Nociception 33 95.12 Very High Very High Very High
Increased Venous Pressure Under Development 5 92.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Relief of inflammatory pain in rats by local use of the selective P2X7 ATP receptor inhibitor, oxidized ATP.
Negative_regulation (inhibitor) of P2X7 associated with analgesic and ipn
1) Confidence 0.41 Published 2002 Journal Arthritis Rheum. Section Title Doc Link 12483745 Disease Relevance 0.10 Pain Relevance 0.43
CONCLUSION: Oxidized ATP inhibits inflammatory pain in arthritic rats by inhibition of the P2X7 receptor for ATP, which is localized on nerve terminals.


Negative_regulation (inhibition) of P2X7 receptor in nerve
2) Confidence 0.41 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12483745 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: Oxidized ATP (oATP) is a selective inhibitor of the P2Z/P2X7 ATP receptor for extracellular ATP, which contributes to the antinociceptive effect.
Negative_regulation (inhibitor) of P2X7 associated with antinociceptive
3) Confidence 0.41 Published 2002 Journal Arthritis Rheum. Section Abstract Doc Link 12483745 Disease Relevance 0.07 Pain Relevance 0.21
CP-96,345 [(2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)-methyl]- 1-azabicyclo[2.2.2.]octan-3-amine], a novel nonpeptide antagonist of the substance P receptor, was evaluated for blocking action at substance P receptors on myenteric neurons of guinea-pig small intestine.
Negative_regulation (antagonist) of P receptor in small intestine associated with antagonist and substance p
4) Confidence 0.32 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7682179 Disease Relevance 0 Pain Relevance 0.39
We showed the antinociceptive activity of oATP, which is able to block the P2X7 receptor [1], in rats bearing acute paw inflammation.
Negative_regulation (block) of P2X7 receptor in paw associated with inflammation and antinociceptive
5) Confidence 0.31 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.44 Pain Relevance 0.37
Indeed, recent studies have reported that MCP-1 recruits neutrophils into brain parenchyma via an unknown pathway [56,57] and that inhibition of P2X7 receptor reduces neutrophil infiltration [58].
Negative_regulation (inhibition) of P2X7 in brain
6) Confidence 0.31 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.30 Pain Relevance 0.07
The question arises about the mechanisms by which the oATP-induced inhibition of P2X7 receptor activation are able to relieve inflammatory pain.
Negative_regulation (inhibition) of P2X7 receptor associated with ipn
7) Confidence 0.26 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.41 Pain Relevance 0.37
They include a loss of binding of IB4, downregulation of the purinergic receptor P2X(3), upregulation of galanin and neuropeptide Y immunoreactivity in large diameter DRG cells, and expression of the transcription factor ATF3.
Negative_regulation (downregulation) of purinergic receptor P2X in IB4 associated with dorsal root ganglion and neuropeptide
8) Confidence 0.25 Published 2003 Journal Neuroscience Section Abstract Doc Link 14568039 Disease Relevance 1.01 Pain Relevance 0.95
Compound 36, for example, a hybrid of a preferred LHS for P2X7 and RHS for KATP possesses potent activity at hP2X7 (pIC50?
Negative_regulation (preferred) of P2X7 associated with potassium channel
9) Confidence 0.21 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0 Pain Relevance 0.45
In both the tetrazoles and triazoles, increasing the length of the spacer between the core and the right hand side aromatic group to two carbons significantly decreased P2X7 potency.
Negative_regulation (decreased) of P2X7 associated with potency
10) Confidence 0.21 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0.51 Pain Relevance 0.81
Compound 36, for example, a hybrid of a preferred LHS for P2X7 and RHS for KATP possesses potent activity at hP2X7 (pIC50?
Negative_regulation (hybrid) of P2X7 associated with potassium channel
11) Confidence 0.21 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0 Pain Relevance 0.45
Fig. 5Cyanoguanidine KATP opener 35 and P2X7 antagonist 36
Negative_regulation (antagonist) of P2X7 associated with antagonist and potassium channel
12) Confidence 0.19 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0 Pain Relevance 0.48
This effect was reduced by pretreatment with the P2X7 receptor antagonist BBG.
Negative_regulation (reduced) of P2X7 associated with antagonist
13) Confidence 0.19 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.69 Pain Relevance 0.36
In the stab-wound model, stimulation of P2 receptors with agonists preferring P2Y1 and P2X7 receptor subtypes promoted the morphological changes of resting to activated microglial cells.
Negative_regulation (preferring) of P2X7 in microglial cells associated with injury and agonist
14) Confidence 0.19 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.60 Pain Relevance 0.16
Recently, it was reported that in mice lacking P2X7 inflammatory and neuropathic hypersensitivity is completely absent to both mechanical and thermal stimuli, whilst normal nociceptive processing is preserved [12].
Negative_regulation (lacking) of P2X7 associated with nociception, inflammation, hypersensitivity and neuropathic pain
15) Confidence 0.16 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 1.77 Pain Relevance 1.11
Similar reductions were evidenced under suffusion of CGRP antibody serum (1:1,000) and after CGRP receptor desensitization but not after substance P receptor desensitization.
Neg (not) Negative_regulation (desensitization) of P receptor associated with substance p
16) Confidence 0.08 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7508205 Disease Relevance 0.75 Pain Relevance 0.52
P2X7 receptors are associated with TNF-?
Negative_regulation (receptors) of P2X7
17) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2861665 Disease Relevance 0.84 Pain Relevance 0.56
Ischemia/reperfusion in ex vivo hearts caused the release of substance P, which was associated with an increase in renin and norepinephrine overflow and with sustained reperfusion arrhythmias; substance P receptor blockade prevented these changes.
Negative_regulation (blockade) of P receptor in hearts associated with ischemia and substance p
18) Confidence 0.00 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20668055 Disease Relevance 0.32 Pain Relevance 0.72

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