INT48259

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 33
Total Number 39
Disease Relevance 10.94
Pain Relevance 14.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adcyap1) signal transduction (Adcyap1) extracellular space (Adcyap1)
extracellular region (Adcyap1)
Anatomy Link Frequency
pituitary 12
ear 3
chromaffin cells 2
dorsal root ganglion 2
plasma 1
Adcyap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 99 100.00 Very High Very High Very High
Calcitonin gene-related peptide 36 100.00 Very High Very High Very High
adenocard 2 100.00 Very High Very High Very High
Neurotransmitter 16 99.86 Very High Very High Very High
dorsal root ganglion 4 99.84 Very High Very High Very High
Endogenous opioid 2 99.84 Very High Very High Very High
amygdala 410 99.68 Very High Very High Very High
Spinal cord 18 99.60 Very High Very High Very High
qutenza 39 99.40 Very High Very High Very High
Dorsal horn 16 99.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 99.36 Very High Very High Very High
Shock 272 99.02 Very High Very High Very High
Nervous System Injury 10 98.36 Very High Very High Very High
Cystitis 5 98.28 Very High Very High Very High
Autoimmune Disease 6 97.80 Very High Very High Very High
INFLAMMATION 67 97.08 Very High Very High Very High
Reprotox - General 1 1 96.80 Very High Very High Very High
Pressure And Volume Under Development 9 96.64 Very High Very High Very High
Death 54 95.88 Very High Very High Very High
Pain 10 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The blood flow in the submandibular gland increased in response to PACAP-38, despite a marked fall in mean aortic blood pressure.
Positive_regulation (increased) of PACAP-38 in submandibular gland
1) Confidence 0.67 Published 1997 Journal Acta Physiol. Scand. Section Abstract Doc Link 9179306 Disease Relevance 0.16 Pain Relevance 0.09
In the dorsal horn of the spinal cord on the intact side PACAP and calcitonin gene-related peptide-immunoreactive fibres were densely accumulated in the superficial layers.
Positive_regulation (accumulated) of PACAP in spinal cord associated with dorsal horn, calcitonin gene-related peptide and spinal cord
2) Confidence 0.65 Published 1996 Journal Neuroscience Section Abstract Doc Link 8895878 Disease Relevance 0.21 Pain Relevance 0.59
Rat adrenal chromaffin cells were invested by a dense network of nerve fibers immunoreactive to pituitary adenylate cyclase activating polypeptide-38 (PACAP-IR).
Positive_regulation (activating) of PACAP-IR in chromaffin cells
3) Confidence 0.64 Published 1996 Journal Brain Res. Section Abstract Doc Link 8738215 Disease Relevance 0.23 Pain Relevance 0.18
These results indicate that PACAP enhances Ca2+ entry via voltage-gated Ca2+ channels and increases [Ca2+]i, which, in turn, stimulates somatodendritic vasopressin release by directly activating PACAP receptors on SON neurons.
Positive_regulation (activating) of PACAP in neurons
4) Confidence 0.64 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9510056 Disease Relevance 0 Pain Relevance 0.19
Pituitary adenylate cyclase activating peptide (PACAP) is a novel vasoactive intestinal polypeptide-like peptide which is present in neuronal elements of a number of peripheral organs.
Positive_regulation (vasoactive) of PACAP in neuronal
5) Confidence 0.50 Published 1996 Journal Neuroscience Section Abstract Doc Link 8809823 Disease Relevance 0 Pain Relevance 0.07
The blocking effect of PACAP is not directly mediated by endogenous opioids because the antagonizing effect of Naloxone, an opioid receptor antagonist, was questionable.
Neg (not) Positive_regulation (mediated) of PACAP associated with antagonist, narcan, endogenous opioid and opioid receptor
6) Confidence 0.50 Published 1996 Journal Acta. Biol. Hung. Section Abstract Doc Link 9123995 Disease Relevance 0 Pain Relevance 0.25
Up-regulation of pituitary adenylate cyclase-activating polypeptide in urinary bladder pathways after chronic cystitis.
Positive_regulation (Up-regulation) of pituitary adenylate cyclase-activating polypeptide in urinary bladder associated with neuropeptide and cystitis
7) Confidence 0.50 Published 2000 Journal J. Comp. Neurol. Section Title Doc Link 10754506 Disease Relevance 0.54 Pain Relevance 0.12
In conclusion, distinct receptors mediate PACAP- and VIP-induced relaxations of rat ileal longitudinal muscle.
Positive_regulation (mediate) of PACAP in longitudinal muscle
8) Confidence 0.49 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9346329 Disease Relevance 0 Pain Relevance 0.13
Pituitary adenylate cyclase activating peptide (PACAP) is a novel vasoactive intestinal peptide-like peptide.
Spec (like) Positive_regulation (vasoactive) of PACAP in Pituitary
9) Confidence 0.49 Published 1993 Journal Neuroscience Section Abstract Doc Link 7906014 Disease Relevance 0.07 Pain Relevance 0.25
In vivo and in vitro experiments were undertaken to evaluate the effects of pituitary adenylate cyclase activating polypeptide-38 (PACAP-38) on rat sympathetic preganglionic neurons (SPNs).
Positive_regulation (activating) of pituitary adenylate cyclase activating polypeptide-38 in pituitary
10) Confidence 0.49 Published 1997 Journal Brain Res. Section Abstract Doc Link 9067461 Disease Relevance 0 Pain Relevance 0.17
In vivo and in vitro experiments were undertaken to evaluate the effects of pituitary adenylate cyclase activating polypeptide-38 (PACAP-38) on rat sympathetic preganglionic neurons (SPNs).
Positive_regulation (activating) of pituitary adenylate cyclase activating polypeptide-38 in pituitary
11) Confidence 0.49 Published 1997 Journal Brain Res. Section Abstract Doc Link 9067461 Disease Relevance 0 Pain Relevance 0.17
In vivo and in vitro experiments were undertaken to evaluate the effects of pituitary adenylate cyclase activating polypeptide-38 (PACAP-38) on rat sympathetic preganglionic neurons (SPNs).
Positive_regulation (activating) of PACAP-38 in pituitary
12) Confidence 0.49 Published 1997 Journal Brain Res. Section Abstract Doc Link 9067461 Disease Relevance 0 Pain Relevance 0.17
The mechanisms leading to the behavioral manifestations of PACAP-shock interactions are not known, but we suggest that administration of PACAP in the CeA, likely acting upon its cognate receptor which is widely
Positive_regulation (administration) of PACAP associated with shock and amygdala
13) Confidence 0.49 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.82 Pain Relevance 0.46
Pituitary adenylate cyclase activating peptide (PACAP) is a vasoactive intestinal peptide-like hypothalamic peptide occurring as two variants, PACAP-27 and the C-terminally extended PACAP-38.
Positive_regulation (vasoactive) of PACAP in Pituitary
14) Confidence 0.48 Published 1993 Journal Neuroscience Section Abstract Doc Link 7508577 Disease Relevance 0 Pain Relevance 0.07
The data obtained indicate a marked up-regulation of PACAP in sensory neurons following peripheral nerve injury.
Positive_regulation (up-regulation) of PACAP in sensory neurons associated with nervous system injury and peripheral nerve injury
15) Confidence 0.47 Published 1996 Journal Neuroscience Section Abstract Doc Link 8895878 Disease Relevance 0.17 Pain Relevance 0.54
PACAP occurs as two variants, PACAP27 and the C-terminally extended PACAP38.
Positive_regulation (occurs) of PACAP27
16) Confidence 0.47 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7739801 Disease Relevance 0.17 Pain Relevance 0.31
It was reported that intravenous (i.v.) injection of PACAP elevated, while intra-cerebro-ventricular (i.c.v.) administration depressed plasma LH levels.
Positive_regulation (elevated) of PACAP in plasma
17) Confidence 0.47 Published 1996 Journal Acta. Biol. Hung. Section Abstract Doc Link 9123995 Disease Relevance 0 Pain Relevance 0.17
Since vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are up-regulated in dorsal root ganglion cells following peripheral nerve injury, we investigated the expression and influence of VPAC1, VPAC2 and PAC1 receptors in rat spinal dorsal horn following a chronic constriction injury (CCI).
Positive_regulation (up-regulated) of PACAP in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nervous system injury, eae, spinal dorsal horn, injury and peripheral nerve injury
18) Confidence 0.46 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10193908 Disease Relevance 0.71 Pain Relevance 0.62
This finding provides strong support for the notion that PACAP is active in modifying CeA functions only when the animal is challenged by an aversive stimulus.
Positive_regulation (active) of PACAP associated with amygdala
19) Confidence 0.45 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.68 Pain Relevance 0.31
The presumed PACAP-induced increase in the activity of the CeA may override the influence of the mPFC (decision-making) process, in favor of the more instinctual immobility responses to shock.
Positive_regulation (increase) of PACAP-induced associated with shock and amygdala
20) Confidence 0.45 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.66 Pain Relevance 0.32

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