INT48269
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
In the mixed group (cortical and subcortical), 5/63 (7.9%) patients had impaired MMSE and FAB; an additional 6/63 (9.52%) had impaired FAB only, which was as follows: motor series (6 patients), conflicting instructions (6), inhibitory control (5), lexical fluency (8), conceptualization (8), and prehensile behavior (2). | |||||||||||||||
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Among the 41 patients with pure cortical infarcts, 21 (51.21%) had impaired MMSE (score < 24) along with impaired FAB. | |||||||||||||||
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An additional 14 (23.33%) patients had impaired FAB only; this was as follows: motor series (9 patients), conflicting instructions (7), inhibitory control (6), lexical fluency (9), conceptualization (7), and prehensile behavior (2). | |||||||||||||||
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An additional 8 (19.51%) patients had impaired FAB only; this was as follows: motor series (4 patients), conflicting instructions (6), inhibitory control (4), lexical fluency (4), conceptualization (6), and prehensile behavior (3). | |||||||||||||||
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When Fab(kappa) was reduced with dithiothreitol (DTT), the Fd fragment in the UF could be separated from the free kappa-chain and the unreduced Fab(kappa) in the BF with a Protein L-Sepharose column. | |||||||||||||||
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Normal MMSE with impaired FAB was seen in 28 patients.
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This seems to be a direct effect of FAB, since there is no confounding by any other variable.
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In the mixed group (cortical and subcortical), 5/63 (7.9%) patients had impaired MMSE and FAB; an additional 6/63 (9.52%) had impaired FAB only, which was as follows: motor series (6 patients), conflicting instructions (6), inhibitory control (5), lexical fluency (8), conceptualization (8), and prehensile behavior (2). | |||||||||||||||
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FAB impairment alone, with MMSE in normal range, was seen in 28/52 (53.8%) patients. | |||||||||||||||
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FAB's are seen to be predictive of outcomes of care where these are measured by disability, but not by severity of pain, [34-39]. | |||||||||||||||
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When Fab(kappa) was reduced with dithiothreitol (DTT), the Fd fragment in the UF could be separated from the free kappa-chain and the unreduced Fab(kappa) in the BF with a Protein L-Sepharose column. | |||||||||||||||
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Further studies are underway to develop alternative heparin dosing strategies in an effort to reduce the occurrence of bleeding complications associated with c7E3 Fab administration and to assess the benefit of c7E3 Fab-mediated platelet inhibition in lower risk patient subgroups. | |||||||||||||||
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Blockade of the receptor, either by monoclonal antibodies or small molecules patterned after the arginine glycine-aspartic acid (RGD) cell recognition domain, prevents arterial thrombosis in animal models much better than does aspirin. c7E3 Fab, the Fab fragment of the mouse/human chimeric antibody 7E3 (abciximab: ReoPro), was shown to reduce ischemic events after angioplasty when given in conjunction with heparin and aspirin to patients at high risk in the EPIC study, but its was associated with an increase in bleeding. | |||||||||||||||
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Blockade of the receptor, either by monoclonal antibodies or small molecules patterned after the arginine glycine-aspartic acid (RGD) cell recognition domain, prevents arterial thrombosis in animal models much better than does aspirin. c7E3 Fab, the Fab fragment of the mouse/human chimeric antibody 7E3 (abciximab: ReoPro), was shown to reduce ischemic events after angioplasty when given in conjunction with heparin and aspirin to patients at high risk in the EPIC study, but its was associated with an increase in bleeding. | |||||||||||||||
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During study drug infusion, ischemia occurred in 9 c7E3 Fab and 16 placebo patients (P = .06). | |||||||||||||||
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inhibitor on a PEGylated Fab fragment (similar to certolizumab) had less placental and milk transfer than a murinzed TNF? | |||||||||||||||
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General Comments
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