INT48269

Context Info Confidence 0.56 First Reported 1994 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 16 Total Number 16 Disease Relevance 5.34 Pain Relevance 1.38

nucleoplasm (FANCB) nucleus (FANCB)

Anatomy Link Frequency 7E3 2 platelet 1 FANCB (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 6 99.96 Pain 54 96.64 Angina 7 91.28 agonist 2 90.48 depression 31 88.48 backache 40 80.16 psoriasis 1 67.60 Multiple sclerosis 10 56.44 rheumatoid arthritis 31 35.60 Etanercept 25 31.04

Disease Link Frequency Relevance Heat Stroke 259 99.92 Anxiety Disorder 31 99.08 Thrombosis 2 99.02 Hemorrhage 8 98.22 Pain 50 96.64 Injury 3 94.60 Cv General 3 Under Development 7 91.28 Myocardial Infarction 3 90.52 Depression 31 88.48 Cognitive Disorder 261 88.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the mixed group (cortical and subcortical), 5/63 (7.9%) patients had impaired MMSE and FAB; an additional 6/63 (9.52%) had impaired FAB only, which was as follows: motor series (6 patients), conflicting instructions (6), inhibitory control (5), lexical fluency (8), conceptualization (8), and prehensile behavior (2).

Negative_regulation (impaired) of FAB

1) Confidence 0.56 Published 2010 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2859587 Disease Relevance 0.20 Pain Relevance 0

Among the 41 patients with pure cortical infarcts, 21 (51.21%) had impaired MMSE (score < 24) along with impaired FAB.

Negative_regulation (impaired) of FAB

2) Confidence 0.56 Published 2010 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2859587 Disease Relevance 0.09 Pain Relevance 0

An additional 14 (23.33%) patients had impaired FAB only; this was as follows: motor series (9 patients), conflicting instructions (7), inhibitory control (6), lexical fluency (9), conceptualization (7), and prehensile behavior (2).

Negative_regulation (impaired) of FAB

3) Confidence 0.56 Published 2010 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2859587 Disease Relevance 0.07 Pain Relevance 0

An additional 8 (19.51%) patients had impaired FAB only; this was as follows: motor series (4 patients), conflicting instructions (6), inhibitory control (4), lexical fluency (4), conceptualization (6), and prehensile behavior (3).

Negative_regulation (impaired) of FAB

4) Confidence 0.56 Published 2010 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2859587 Disease Relevance 0.09 Pain Relevance 0

When Fab(kappa) was reduced with dithiothreitol (DTT), the Fd fragment in the UF could be separated from the free kappa-chain and the unreduced Fab(kappa) in the BF with a Protein L-Sepharose column.

Negative_regulation (reduced) of Fab

5) Confidence 0.42 Published 1997 Journal Immunol. Invest. Section Abstract Doc Link 9246561 Disease Relevance 0.17 Pain Relevance 0.08

Normal MMSE with impaired FAB was seen in 28 patients.

Negative_regulation (impaired) of FAB

6) Confidence 0.41 Published 2010 Journal Annals of Indian Academy of Neurology Section Abstract Doc Link PMC2859587 Disease Relevance 0.71 Pain Relevance 0

This seems to be a direct effect of FAB, since there is no confounding by any other variable.

Negative_regulation (effect) of FAB

7) Confidence 0.40 Published 2007 Journal Spine Section Body Doc Link 17632397 Disease Relevance 0 Pain Relevance 0

In the mixed group (cortical and subcortical), 5/63 (7.9%) patients had impaired MMSE and FAB; an additional 6/63 (9.52%) had impaired FAB only, which was as follows: motor series (6 patients), conflicting instructions (6), inhibitory control (5), lexical fluency (8), conceptualization (8), and prehensile behavior (2).

Negative_regulation (impaired) of FAB

8) Confidence 0.36 Published 2010 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2859587 Disease Relevance 0.20 Pain Relevance 0

FAB impairment alone, with MMSE in normal range, was seen in 28/52 (53.8%) patients.

Negative_regulation (impairment) of FAB

9) Confidence 0.36 Published 2010 Journal Annals of Indian Academy of Neurology Section Abstract Doc Link PMC2859587 Disease Relevance 0.70 Pain Relevance 0

FAB's are seen to be predictive of outcomes of care where these are measured by disability, but not by severity of pain, [34-39].

Negative_regulation (predictive) of FAB associated with pain

10) Confidence 0.33 Published 2010 Journal Chiropr Osteopat Section Body Doc Link PMC2923166 Disease Relevance 1.40 Pain Relevance 0.61

When Fab(kappa) was reduced with dithiothreitol (DTT), the Fd fragment in the UF could be separated from the free kappa-chain and the unreduced Fab(kappa) in the BF with a Protein L-Sepharose column.

Negative_regulation (unreduced) of Fab

11) Confidence 0.31 Published 1997 Journal Immunol. Invest. Section Abstract Doc Link 9246561 Disease Relevance 0.16 Pain Relevance 0.08

Further studies are underway to develop alternative heparin dosing strategies in an effort to reduce the occurrence of bleeding complications associated with c7E3 Fab administration and to assess the benefit of c7E3 Fab-mediated platelet inhibition in lower risk patient subgroups.

Negative_regulation (inhibition) of Fab-mediated in platelet associated with hemorrhage

12) Confidence 0.20 Published 1994 Journal J Invasive Cardiol Section Abstract Doc Link 10155090 Disease Relevance 0.43 Pain Relevance 0.09

Blockade of the receptor, either by monoclonal antibodies or small molecules patterned after the arginine glycine-aspartic acid (RGD) cell recognition domain, prevents arterial thrombosis in animal models much better than does aspirin. c7E3 Fab, the Fab fragment of the mouse/human chimeric antibody 7E3 (abciximab: ReoPro), was shown to reduce ischemic events after angioplasty when given in conjunction with heparin and aspirin to patients at high risk in the EPIC study, but its was associated with an increase in bleeding.

Negative_regulation (reduce) of Fab fragment in 7E3 associated with aspirin, hemorrhage and thrombosis

13) Confidence 0.16 Published 1996 Journal Haemostasis Section Abstract Doc Link 8979134 Disease Relevance 0.32 Pain Relevance 0.21

Blockade of the receptor, either by monoclonal antibodies or small molecules patterned after the arginine glycine-aspartic acid (RGD) cell recognition domain, prevents arterial thrombosis in animal models much better than does aspirin. c7E3 Fab, the Fab fragment of the mouse/human chimeric antibody 7E3 (abciximab: ReoPro), was shown to reduce ischemic events after angioplasty when given in conjunction with heparin and aspirin to patients at high risk in the EPIC study, but its was associated with an increase in bleeding.

Negative_regulation (reduce) of c7E3 Fab in 7E3 associated with aspirin, hemorrhage and thrombosis

14) Confidence 0.14 Published 1996 Journal Haemostasis Section Abstract Doc Link 8979134 Disease Relevance 0.32 Pain Relevance 0.21

During study drug infusion, ischemia occurred in 9 c7E3 Fab and 16 placebo patients (P = .06).

Negative_regulation (occurred) of c7E3 Fab

15) Confidence 0.08 Published 1994 Journal Circulation Section Body Doc Link 7508826 Disease Relevance 0 Pain Relevance 0

inhibitor on a PEGylated Fab fragment (similar to certolizumab) had less placental and milk transfer than a murinzed TNF?

Negative_regulation (inhibitor) of Fab

16) Confidence 0.04 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971732 Disease Relevance 0.48 Pain Relevance 0.11

General Comments

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