INT48277

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Context Info
Confidence 0.59
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.69
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (BDKRB2) plasma membrane (BDKRB2) signal transducer activity (BDKRB2)
Anatomy Link Frequency
blood 1
nerve 1
CHO 1
BDKRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 113 100.00 Very High Very High Very High
b2 receptor 16 100.00 Very High Very High Very High
aspirin 10 99.98 Very High Very High Very High
tetrodotoxin 1 98.74 Very High Very High Very High
Pain 6 98.12 Very High Very High Very High
Inflammation 26 97.76 Very High Very High Very High
substance P 3 97.36 Very High Very High Very High
antagonist 12 93.28 High High
qutenza 3 88.80 High High
Inflammatory response 1 88.76 High High
Disease Link Frequency Relevance Heat
Pain 6 98.12 Very High Very High Very High
INFLAMMATION 28 97.76 Very High Very High Very High
Retinal Diseases 5 89.72 High High
Placenta Accreta 1 89.28 High High
Diabetes Mellitus 130 89.08 High High
Diabetic Retinopathy 29 87.12 High High
Retina Disease 2 76.08 Quite High
Spontaneous Abortion 1 75.68 Quite High
Apoptosis 1 75.20 Quite High
Pressure And Volume Under Development 7 74.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DesArg(10)KD (100 nM) had no effect on B2R but increased B1R (3- to 4-fold) with the same rate as BK.
Neg (no) Regulation (effect) of B2R associated with bradykinin
1) Confidence 0.59 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419551 Disease Relevance 0.25 Pain Relevance 0.83
We hypothesized that kinins autoregulate B2R and B1R expression in favor of B1R.
Regulation (autoregulate) of B2R
2) Confidence 0.43 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419551 Disease Relevance 0.28 Pain Relevance 0.77
Aspirin effect on B2 receptor binding properties is not accompanied by alteration of the cell-surface organization of the receptor in dimers and monomers.
Regulation (effect) of B2 receptor associated with aspirin and b2 receptor
3) Confidence 0.26 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18355801 Disease Relevance 0.27 Pain Relevance 1.16
B2R, a member of the G protein-coupled receptor (GPCR) superfamily, is a potential drug target in the treatment of cardiovascular disorders, pain and inflammation.
Regulation (target) of B2R associated with pain and inflammation
4) Confidence 0.25 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16740128 Disease Relevance 0.20 Pain Relevance 0.34
However, tetrodotoxin (+/-)-CP-96,345, SR 48968, and atropine did not significantly affect Bk concentration-response curves, suggesting that nerve conduction, substance P (SP), neurokinin A (NKA), and acetylcholine release are not involved in Bk action.
Neg (not) Regulation (affect) of Bk in nerve associated with tetrodotoxin, bradykinin and substance p
5) Confidence 0.20 Published 1994 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 7509245 Disease Relevance 0 Pain Relevance 1.12
We have recently demonstrated the importance of the B2R in the recruitment of circulating pro-angiogenic cell types as well as in the subsequent mounting of revascularization and recovery of blood flow in ischemic tissue [11].
Regulation (importance) of B2R in blood
6) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887352 Disease Relevance 0.38 Pain Relevance 0.19
CHO-B2 cell is a useful system that can be applied to study the effect of potential agents that may influence the B2 receptor function.
Regulation (influence) of B2 receptor in CHO associated with b2 receptor
7) Confidence 0.10 Published 2001 Journal Int. Immunopharmacol. Section Abstract Doc Link 11379050 Disease Relevance 0 Pain Relevance 0.60
The immunoreactivity of the B2R shares the same distribution of kallikrein mRNA, and like kallikrein, is more intense in the first trimester as compared to term.
Regulation (immunoreactivity) of B2R
8) Confidence 0.09 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.30 Pain Relevance 0
Vitreous fluorophotometry has been used to quantify the alteration of the BRB (Cunha-Vaz et al 1975).
Regulation (alteration) of BRB
9) Confidence 0.04 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693968 Disease Relevance 1.02 Pain Relevance 0.04

General Comments

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