INT48289

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Context Info
Confidence 0.60
First Reported 1993
Last Reported 2009
Negated 2
Speculated 0
Reported most in Title
Documents 4
Total Number 5
Disease Relevance 0.35
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tacr2) plasma membrane (Tacr2) signal transducer activity (Tacr2)
Anatomy Link Frequency
uterus 1
muscle 1
colon 1
Tacr2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 10 100.00 Very High Very High Very High
qutenza 4 100.00 Very High Very High Very High
agonist 24 99.24 Very High Very High Very High
substance P 28 99.20 Very High Very High Very High
tetrodotoxin 2 89.20 High High
Calcium channel 1 48.52 Quite Low
Inflammatory mediators 2 44.68 Quite Low
Central nervous system 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dyspnea 3 88.76 High High
Eclampsia 2 59.12 Quite High
Increased Venous Pressure Under Development 2 50.96 Quite High
INFLAMMATION 2 44.28 Quite Low
Endometriosis (extended) 2 22.72 Low Low
Reprotox - General 1 2 5.00 Very Low Very Low Very Low
Hypogonadotropic Hypogonadism 2 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Asthma 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these findings suggest that, at least in the mouse uterus, the Tacr2 gene is not a direct target for ovarian steroids.
Neg (not) Regulation (target) of Tacr2 in uterus
1) Confidence 0.60 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0.11 Pain Relevance 0.09
Compared with uteri from control, vehicle-treated mice, E2 and P4 (alone or in combination), PPT, DPN and estren did not cause significant alterations in Tacr2 mRNA levels (P > 0.05, Figs. 3B and 4B).
Neg (not) Regulation (alterations) of Tacr2
2) Confidence 0.26 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0
Effect of longitudinal muscle-myenteric plexus removal and indomethacin on the response to tachykinin NK-2 and NK-3 receptor agonists in the circular muscle of the guinea-pig ileum.
Regulation (response) of tachykinin NK-2 in muscle associated with agonist
3) Confidence 0.06 Published 1994 Journal J Auton Pharmacol Section Title Doc Link 7512089 Disease Relevance 0 Pain Relevance 0.25
The effects of three tachykinin NK1 receptor antagonists and a tachykinin NK2 receptor antagonist against substance P-induced contractions of the guinea-pig proximal colon longitudinal muscle were investigated.
Regulation (effects) of tachykinin NK2 receptor in colon associated with antagonist and substance p
4) Confidence 0.05 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7509752 Disease Relevance 0 Pain Relevance 0.42
[Effect of a novel tachykinin NK-2-receptor antagonist, TAC-363, on bronchoconstriction and airway hyperresponsiveness in guinea pigs].
Regulation ([Effect) of NK-2-receptor associated with qutenza and antagonist
5) Confidence 0.04 Published 1997 Journal Nippon Yakurigaku Zasshi Section Title Doc Link 9067996 Disease Relevance 0.24 Pain Relevance 0.44

General Comments

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