INT4829

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Context Info
Confidence 0.55
First Reported 1981
Last Reported 2010
Negated 16
Speculated 8
Reported most in Abstract
Documents 199
Total Number 214
Disease Relevance 20.91
Pain Relevance 150.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
neurons 20
spinal cord 12
hippocampus 12
interneurons 10
synapses 10
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 2074 100.00 Very High Very High Very High
Dopamine 1429 100.00 Very High Very High Very High
Glutamate 711 100.00 Very High Very High Very High
Calcium channel 70 100.00 Very High Very High Very High
GABA receptor 64 100.00 Very High Very High Very High
Ventral tegmentum 43 100.00 Very High Very High Very High
qutenza 19 100.00 Very High Very High Very High
nociceptor 5 100.00 Very High Very High Very High
agonist 465 99.98 Very High Very High Very High
Gabapentin 194 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 148 99.92 Very High Very High Very High
Stress 253 99.74 Very High Very High Very High
Pressure And Volume Under Development 20 99.62 Very High Very High Very High
Cerebral Infarction 26 99.58 Very High Very High Very High
Convulsion 128 99.56 Very High Very High Very High
Targeted Disruption 28 99.56 Very High Very High Very High
INFLAMMATION 25 99.16 Very High Very High Very High
Urological Neuroanatomy 154 99.08 Very High Very High Very High
Neuropathic Pain 144 98.72 Very High Very High Very High
Sprains And Strains 12 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clonidine (0.001-1 microM) increased the basal release of endogenous gamma-aminobutyric acid (GABA) in superfused synaptosomes from whole rat cerebral cortex.
Positive_regulation (increased) of Localization (release) of GABA in cerebral cortex associated with gaba, cerebral cortex and clonidine
1) Confidence 0.55 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2835479 Disease Relevance 0 Pain Relevance 0.77
Clozapine (5.0 mg/kg) increased GABA release in the fundus striati and haloperidol (0.5 mg/kg) increased GABA release in the globus pallidus.
Positive_regulation (increased) of Localization (release) of GABA in fundus associated with gaba
2) Confidence 0.47 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2073921 Disease Relevance 0 Pain Relevance 0.50
Hypothalamic superfusion with a potassium-rich (50 or 90 mmol/l) artificial cerebrospinal fluid led to a concentration-dependent increase in the GABA release.
Positive_regulation (increase) of Localization (release) of GABA in cerebrospinal fluid associated with gaba
3) Confidence 0.47 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8510767 Disease Relevance 0.31 Pain Relevance 0.55
In the absence of Ca2+, the K+-induced release of aspartate, glutamate, and GABA was blocked whereas the K+-induced release of taurine was still present.
Positive_regulation (induced) of Localization (release) of GABA associated with gaba and glutamate
4) Confidence 0.46 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2872275 Disease Relevance 0 Pain Relevance 0.45
Evoked GABA release is not mediated by N-type VDCC in the frontal cortex of awake rats: effects of neomycin.
Neg (not) Positive_regulation (mediated) of Localization (release) of GABA in frontal cortex associated with gaba and urological neuroanatomy
5) Confidence 0.44 Published 1997 Journal Brain Res. Bull. Section Title Doc Link 9250617 Disease Relevance 0.24 Pain Relevance 0.75
Thus, haloperidol and clozapine are clearly distinguished by their effects on GABA release in the fundus striati and globus pallidus (both drugs increased GABA release in the dorsolateral striatum).
Positive_regulation (increased) of in globus pallidus Localization (release) of GABA in striatum associated with gaba
6) Confidence 0.41 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2073921 Disease Relevance 0 Pain Relevance 0.84
In contrast, clozapine (2.5-40 mg/kg) failed to increase GABA release in the globus pallidus and haloperidol (0.1-2.0 mg/kg) failed to increase GABA release in the fundus.
Neg (failed) Positive_regulation (increase) of Localization (release) of GABA in globus pallidus associated with gaba
7) Confidence 0.41 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2073921 Disease Relevance 0 Pain Relevance 0.69
Clozapine (5.0 mg/kg) increased GABA release in the fundus striati and haloperidol (0.5 mg/kg) increased GABA release in the globus pallidus.
Positive_regulation (increased) of in fundus Localization (release) of GABA in globus pallidus associated with gaba
8) Confidence 0.41 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2073921 Disease Relevance 0 Pain Relevance 0.57
Clozapine (5.0 mg/kg) increased GABA release in the fundus striati and haloperidol (0.5 mg/kg) increased GABA release in the globus pallidus.
Positive_regulation (increased) of Localization (release) of GABA in globus pallidus associated with gaba
9) Confidence 0.41 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2073921 Disease Relevance 0 Pain Relevance 0.56
Drug-induced increases in GABA and dopamine release were reversed by addition of 1 microM tetrodotoxin to the perfusion medium.
Positive_regulation (increases) of Localization (release) of GABA associated with tetrodotoxin, dopamine and gaba
10) Confidence 0.41 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2073921 Disease Relevance 0 Pain Relevance 0.96
In contrast, clozapine (2.5-40 mg/kg) failed to increase GABA release in the globus pallidus and haloperidol (0.1-2.0 mg/kg) failed to increase GABA release in the fundus.
Neg (failed) Positive_regulation (increase) of Localization (release) of GABA in fundus associated with gaba
11) Confidence 0.41 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2073921 Disease Relevance 0 Pain Relevance 0.76
In addition, we observed that only acute withdrawal moderately increased stimulated GABA release.
Positive_regulation (increased) of Localization (release) of GABA associated with gaba and withdrawal
12) Confidence 0.41 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16540107 Disease Relevance 0.14 Pain Relevance 1.19
L-Glutamic acid initially enhanced the GABA release and subsequently reduced it to a level below the baseline rate.
Positive_regulation (enhanced) of Localization (release) of GABA associated with gaba
13) Confidence 0.41 Published 1981 Journal Brain Res. Section Abstract Doc Link 6118201 Disease Relevance 0 Pain Relevance 0.39
Systemic administration of adenosine A(2A) receptor antagonist reverses increased GABA release in the globus pallidus of unilateral 6-hydroxydopamine-lesioned rats: a microdialysis study.
Positive_regulation (increased) of Localization (release) of GABA in globus pallidus associated with gaba, adenocard and antagonist
14) Confidence 0.41 Published 2000 Journal Neuroscience Section Title Doc Link 10996458 Disease Relevance 0 Pain Relevance 0.69
Basal and evoked GABA release, which was reduced by 58 and 96%, respectively, in the excitotoxin-lesioned striatum, was restored by the striatal grafts to levels close to or above those observed in normal striata.
Positive_regulation (restored) of Localization (release) of GABA in striatum associated with gaba
15) Confidence 0.41 Published 1993 Journal Neuroscience Section Abstract Doc Link 8098510 Disease Relevance 0 Pain Relevance 0.48
The application of kainic acid to neostriatum enhanced the release of GABA, taurine, aspartate and glutamate locally in the neostriatum and distally in the substantia nigra.
Positive_regulation (enhanced) of Localization (release) of GABA in substantia nigra associated with glutamate, gaba and substantia nigra
16) Confidence 0.41 Published 1998 Journal Neuroscience Section Abstract Doc Link 9722150 Disease Relevance 0 Pain Relevance 0.68
It has previously been demonstrated, in dual probe microdialysis studies, that stimulation of the neostriatum with kainic acid causes the release of GABA both locally within the neostriatum and distally in the substantia nigra, observations that are consistent with the known anatomy of the basal ganglia.
Positive_regulation (causes) of Localization (release) of GABA in basal ganglia associated with gaba and substantia nigra
17) Confidence 0.41 Published 1998 Journal Neuroscience Section Abstract Doc Link 9722150 Disease Relevance 0 Pain Relevance 0.24
Veratrine (1-30 microM) induced the release of [3H]GABA and the effect was tetrodotoxin-sensitive. (-)-Baclofen, but not muscimol, decreased the veratrine-induced [3H]GABA release; the GABAB agonist was particularly effective in presence of low concentrations of veratrine (1-3 microM) but the effect disappeared when 30 microM of the alkaloid was used.
Positive_regulation (induced) of Localization (release) of GABA associated with tetrodotoxin, gaba and agonist
18) Confidence 0.41 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2540998 Disease Relevance 0 Pain Relevance 0.67
The release of GABA per min is dependent on the flow rates, when low perfusion rates were applied.
Positive_regulation (dependent) of Localization (release) of GABA associated with gaba
19) Confidence 0.41 Published 1981 Journal Adv. Biochem. Psychopharmacol. Section Abstract Doc Link 6266211 Disease Relevance 0 Pain Relevance 0.75
The GABA release was enhanced by K+ (maximal effect at 50 mM).
Positive_regulation (enhanced) of Localization (release) of GABA associated with gaba
20) Confidence 0.41 Published 1981 Journal Adv. Biochem. Psychopharmacol. Section Abstract Doc Link 6266211 Disease Relevance 0 Pain Relevance 0.82

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