INT48307

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Context Info
Confidence 0.66
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 8
Disease Relevance 8.42
Pain Relevance 5.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PLP1) structural molecule activity (PLP1)
Anatomy Link Frequency
CSF 4
brain 1
optic 1
PLP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 68 99.36 Very High Very High Very High
Neuritis 24 98.96 Very High Very High Very High
Central nervous system 16 98.16 Very High Very High Very High
Inflammation 8 77.20 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 68 99.36 Very High Very High Very High
Disease 8 99.14 Very High Very High Very High
Optic Neuritis 24 98.96 Very High Very High Very High
Recurrence 8 98.40 Very High Very High Very High
INFLAMMATION 8 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The remaining 6 patients with undetectable anti-MBP had increased levels of anti-PLP in their CSF.
Positive_regulation (increased) of PLP in CSF
1) Confidence 0.66 Published 1994 Journal J. Neurol. Sci. Section Abstract Doc Link 7510787 Disease Relevance 1.14 Pain Relevance 0.63
Considering the total of 370 clinically definite MS patients with active and inactive disease, 77% had increased CSF anti-MBP and 1% had increased CSF anti-PLP.
Positive_regulation (increased) of CSF anti-PLP in CSF associated with multiple sclerosis and disease
2) Confidence 0.66 Published 1994 Journal J. Neurol. Sci. Section Abstract Doc Link 7510787 Disease Relevance 1.12 Pain Relevance 0.61
Three of the 4 remaining patients with undetectable anti-MBP had increased anti-PLP in their CSF.
Positive_regulation (increased) of PLP in CSF
3) Confidence 0.66 Published 1994 Journal J. Neurol. Sci. Section Abstract Doc Link 7510787 Disease Relevance 1.20 Pain Relevance 0.66
Of 110 MS patients with chronic progressive disease, 107 had increased CSF anti-MBP and 2 had elevated anti-PLP.
Positive_regulation (elevated) of PLP in CSF associated with multiple sclerosis and disease
4) Confidence 0.66 Published 1994 Journal J. Neurol. Sci. Section Abstract Doc Link 7510787 Disease Relevance 1.19 Pain Relevance 0.65
Forty-nine of 55 patients with optic neuritis had increased CSF anti-MBP and the remaining 6 had increased anti-PLP.
Positive_regulation (increased) of anti-PLP in optic associated with optic neuritis and neuritis
5) Confidence 0.58 Published 1994 Journal Ann. Neurol. Section Abstract Doc Link 7510098 Disease Relevance 0.91 Pain Relevance 0.56
Of 385 MS patients, MS relapse: 173 of 180 patients had increased anti-MBP, 5 of the remaining 7 patients had elevated anti-PLP, and 2 had neither of these autoantibodies.
Positive_regulation (elevated) of anti-PLP associated with multiple sclerosis and recurrence
6) Confidence 0.42 Published 1994 Journal Ann. Neurol. Section Abstract Doc Link 7510098 Disease Relevance 0.97 Pain Relevance 0.62
Progressive MS: 111 of 116 patients had increased anti-MBP in either free and/or bound form, of the remaining 5 patients 4 had increased anti-PLP, and 1 had neither anti-MBP nor anti-PLP.
Positive_regulation (increased) of anti-PLP associated with multiple sclerosis
7) Confidence 0.42 Published 1994 Journal Ann. Neurol. Section Abstract Doc Link 7510098 Disease Relevance 0.94 Pain Relevance 0.63
The fourth patient who had anti-PLP in CSF also had anti-PLP in brain tissue IgG.
Positive_regulation (had) of anti-PLP in brain
8) Confidence 0.39 Published 1994 Journal Ann. Neurol. Section Abstract Doc Link 7510098 Disease Relevance 0.95 Pain Relevance 0.71

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