INT48308

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Context Info
Confidence 0.48
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 9.59
Pain Relevance 6.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PLP1) structural molecule activity (PLP1)
Anatomy Link Frequency
CSF 1
T cells 1
PLP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 97 100.00 Very High Very High Very High
depression 43 100.00 Very High Very High Very High
Central nervous system 5 99.50 Very High Very High Very High
Inflammation 2 98.88 Very High Very High Very High
Multiple sclerosis 17 98.44 Very High Very High Very High
headache 2 94.24 High High
Lamotrigine 1 91.48 High High
phantom limb 6 89.28 High High
antidepressant 57 81.68 Quite High
Neuritis 6 75.00 Quite High
Disease Link Frequency Relevance Heat
Pain 92 100.00 Very High Very High Very High
Depression 80 100.00 Very High Very High Very High
Amputation 15 99.62 Very High Very High Very High
INFLAMMATION 3 98.88 Very High Very High Very High
Demyelinating Disease 17 98.44 Very High Very High Very High
Togavirus Infection 6 98.32 Very High Very High Very High
Hallucination 1 97.32 Very High Very High Very High
Fever 1 94.52 High High
Headache 1 94.24 High High
Psychosis 3 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability to move the phantom (P = .01) and stump pain (P = .01) were postamputation factors associated with PLP.
PLP Binding (associated) of associated with pain
1) Confidence 0.48 Published 2007 Journal J Pain Section Abstract Doc Link 17631056 Disease Relevance 1.91 Pain Relevance 1.60
These findings are suggesting 2 immunochemically distinct forms of MS: a common form with autoantibodies directed against MBP and a more rare form associated with anti-PLP.
PLP Binding (associated) of associated with multiple sclerosis
2) Confidence 0.36 Published 1994 Journal J. Neurol. Sci. Section Abstract Doc Link 7510787 Disease Relevance 1.13 Pain Relevance 0.57
The use of high levels of passive coping strategies (P = .001), especially catastrophizing (P = .02) before amputation, were found to be associated with PLP development.
PLP Binding (associated) of associated with pain and amputation
3) Confidence 0.35 Published 2007 Journal J Pain Section Abstract Doc Link 17631056 Disease Relevance 1.91 Pain Relevance 1.50
[A case report of subacute panencephalitis associated with specific T cells sensitized to proteolipid protein (PLP) synthetic peptides identified with rubella virus].
proteolipid protein Binding (sensitized) of in T cells associated with togavirus infection
4) Confidence 0.35 Published 1996 Journal Rinsho Shinkeigaku Section Title Doc Link 8976131 Disease Relevance 1.19 Pain Relevance 0.12
This study was devised to identify physical and psychological factors associated with PLP development and maintenance.
PLP Binding (associated) of associated with pain
5) Confidence 0.31 Published 2007 Journal J Pain Section Abstract Doc Link 17631056 Disease Relevance 1.40 Pain Relevance 1.02
These results suggest that there are at least two immunologically distinct forms of MS, i.e., a common form highly associated with anti-MBP and more frequent prominent inflammatory characteristics in CSF and CNS, and an infrequent form associated with anti-PLP in CSF and tissue, and less abundant inflammation.
anti-PLP Binding (associated) of in CSF associated with multiple sclerosis, inflammation and central nervous system
6) Confidence 0.31 Published 1994 Journal Ann. Neurol. Section Abstract Doc Link 7510098 Disease Relevance 0.79 Pain Relevance 0.56
PMD is associated with greater illness severity, impairment, comorbidity, and mortality when compared with MDD.
PMD Binding (associated) of associated with depression
7) Confidence 0.01 Published 2010 Journal Core evidence Section Body Doc Link PMC2899788 Disease Relevance 1.24 Pain Relevance 0.71

General Comments

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