INT48310

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Context Info
Confidence 0.48
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 9.72
Pain Relevance 8.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngfr) nuclear envelope (Ngfr) Golgi apparatus (Ngfr)
plasma membrane (Ngfr) nucleus (Ngfr) cytoplasm (Ngfr)
Anatomy Link Frequency
neuronal 2
sensory neurons 1
ventral roots 1
neural crest 1
neuron 1
Ngfr (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 395 100.00 Very High Very High Very High
unmyelinated 9 99.76 Very High Very High Very High
neurotrophin 3 3 99.52 Very High Very High Very High
Calcitonin gene-related peptide 32 99.28 Very High Very High Very High
Neurotransmitter 21 98.72 Very High Very High Very High
substance P 25 98.60 Very High Very High Very High
addiction 4 98.56 Very High Very High Very High
Opioid 14 98.16 Very High Very High Very High
analgesia 4 97.72 Very High Very High Very High
Spinal cord 34 97.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Suicidal Behaviour 738 99.96 Very High Very High Very High
Death 272 99.92 Very High Very High Very High
Apoptosis 495 99.32 Very High Very High Very High
Cancer 26 98.92 Very High Very High Very High
Necrosis 16 98.68 Very High Very High Very High
Opiate Addiction 6 98.56 Very High Very High Very High
Reprotox - General 1 94 98.24 Very High Very High Very High
Spinal Cord Injury 15 97.44 Very High Very High Very High
Neurodegenerative Disease 134 95.92 Very High Very High Very High
Drug Dependence 6 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because neurotrophins universally bind the p75 neurotrophin receptor (p75NTR), we investigated whether the activity of this receptor is involved in the development of opioid analgesic tolerance and physical dependence.
p75 neurotrophin receptor Binding (bind) of associated with physical dependence, analgesic, tolerance and opioid
1) Confidence 0.48 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19114089 Disease Relevance 0.37 Pain Relevance 1.76
Because neurotrophins universally bind the p75 neurotrophin receptor (p75NTR), we investigated whether the activity of this receptor is involved in the development of opioid analgesic tolerance and physical dependence.
p75NTR Binding (bind) of associated with physical dependence, analgesic, tolerance and opioid
2) Confidence 0.48 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19114089 Disease Relevance 0.37 Pain Relevance 1.77
These data suggest that there is no direct genetic interaction between p75NTR and Necdin to prevent the regulated cell death in post-mitotic developing sensory neurons.


p75NTR Neg (no) Binding (interaction) of in sensory neurons associated with death
3) Confidence 0.45 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.48 Pain Relevance 0
Binding of a neurotrophin to the appropriate Trk receptor leads to the dimerization and transphosphorylation of tyrosine residues in the intracellular domain of the Trk receptors and subsequent activation of cytoplasmic signaling pathways.50,51 All neurotrophins can bind to the pan75 neurotrophin receptor (p75NTR), which plays a role in neurotrophin transport, ligand binding specificity, and Trk functioning.44,52,53
p75NTR Binding (bind) of
4) Confidence 0.21 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.14 Pain Relevance 0.10
Binding of a neurotrophin to the appropriate Trk receptor leads to the dimerization and transphosphorylation of tyrosine residues in the intracellular domain of the Trk receptors and subsequent activation of cytoplasmic signaling pathways.50,51 All neurotrophins can bind to the pan75 neurotrophin receptor (p75NTR), which plays a role in neurotrophin transport, ligand binding specificity, and Trk functioning.44,52,53
neurotrophin receptor Binding (bind) of
5) Confidence 0.21 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.14 Pain Relevance 0.10
During EB culture in BDNF(+) medium, we detected each immunoreactivity associated with the trk proto-oncogenes (trkB; BDNF receptors) and neural crest marker, proto-oncogene tyrosine-protein kinase receptor ret precursor (c-ret), p75, or sox9.
p75 Binding (associated) of in neural crest
6) Confidence 0.20 Published 2006 Journal Stem Cells Section Abstract Doc Link 16527901 Disease Relevance 0 Pain Relevance 0.07
Binding of a neurotrophin to the appropriate Trk receptor leads to the dimerization and transphosphorylation of tyrosine residues in the intracellular domain of the Trk receptors and subsequent activation of cytoplasmic signaling pathways.50,51 All neurotrophins can bind to the pan75 neurotrophin receptor (p75NTR), which plays a role in neurotrophin transport, ligand binding specificity, and Trk functioning.44,52,53
p75NTR Binding (bind) of
7) Confidence 0.17 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.14 Pain Relevance 0.10
Binding of a neurotrophin to the appropriate Trk receptor leads to the dimerization and transphosphorylation of tyrosine residues in the intracellular domain of the Trk receptors and subsequent activation of cytoplasmic signaling pathways.50,51 All neurotrophins can bind to the pan75 neurotrophin receptor (p75NTR), which plays a role in neurotrophin transport, ligand binding specificity, and Trk functioning.44,52,53
p75NTR Binding (pan75) of
8) Confidence 0.17 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.14 Pain Relevance 0.10
Recently, it has been shown that pro-BDNF binds preferentially to p75NTR and elicits apoptosis as opposed to mature BDNF, which binds weakly with p75NTR but with high affinity to TrkB, where it exerts neuroprotective activity.60,225 Thus, pro-BDNF and mature BDNF cause opposite physiological actions through binding to p75NTR and TrkB receptors, respectively.55 In fact, it has been shown that pro-BDNF facilitates long-term depression via activation of p75NTR.226 On the other hand, TrkB plays a critical role in early-phase long-term potentiation227 and conversion of pro-BDNF to mature BDNF is essential for TrkB-mediated late-phase long-term potentiation.61 In a recent preliminary study, we observed that the level of pro-BDNF is increased PFC and hippocampus of suicide subjects (unpublished observation), whereas a recent genetic study suggests that the S205L polymorphism, which substitutes a serine with a leucine residue, of the p75NTR gene is associated with attempted suicide.228 These studies reveal the crucial roles of pro-BDNF and p75NTR in suicidal behavior.


p75NTR Binding (binds) of in hippocampus associated with suicidal behaviour, depression, hippocampus, long-term potentiation and apoptosis
9) Confidence 0.16 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.72 Pain Relevance 0.16
Necdin interacted with both TrkA and p75 to facilitate the association between these receptors.
p75 Binding (interacted) of
10) Confidence 0.16 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16049186 Disease Relevance 0.36 Pain Relevance 0.30
The common p75NTR also enhances binding of NGF to TrkA receptors to create high affinity binding sites (Kd~10-11 M), possibly by binding to different surfaces on the NGF dimer [6]. p75NTR can also bind precursor forms of the neurotrophins.
p75NTR Binding (binding) of associated with nerve growth factor
11) Confidence 0.14 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.28 Pain Relevance 0.33
All neurotrophins bind p75NTR with similar affinity (Kd~10-9 M), but binding to the Trk receptors is more selective.
p75NTR Binding (bind) of
12) Confidence 0.14 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.17 Pain Relevance 0.24
One complication, however, is that neurotrophins also bind to p75NTR.
p75NTR Binding (bind) of
13) Confidence 0.14 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.76 Pain Relevance 0.08
NGF's growth-promoting effects are mediated via binding and activation of high affinity trkA Neurotrophin receptor [for review, see [46]].
trkA Neurotrophin receptor Binding (binding) of associated with nerve growth factor
14) Confidence 0.14 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.51 Pain Relevance 0.71
p75NTR, initially discovered as a low-affinity receptor for NGF, is now known as a class of receptor that can bind to all neurotrophins with equivalent nanomolar affinities.198 The 3.8-kb mRNA for p75NTR encodes a 427-amino acid protein containing a 28-amino acid single peptide, a single transmembrane domain, and a 55-amino acid cytoplasmic domain.199 Although p75NTR receptors do not contain a catalytic motif, they interact with several proteins, including Trk receptors, which causes enhancement of ligand specificity and ligand affinities for Trk receptors.200–202 Functionally, in contrast to Trk receptors, which contain autophosphorylation sites and are involved in cell survival, p75NTR lacks intrinsic enzymatic activity and can transmit both positive and negative signals.203 It has been shown that p75NTR can mediate neuronal apoptosis when the cognate Trk receptor is less activated or not activated.204 Similarly, p75NTR can cause developing hippocampal neuronal death induced by neurotrophins in the absence of a Trk receptor.205–207 In the adult CNS, it has been shown that excitotoxin-induced neuronal apoptosis is accompanied by the induction of p75NTR in the dying neurons,208 which suggests that p75NTR may represent a general stress-induced apoptotic mechanism.209 However, the apoptotic mechanisms of p75NTR are active only when Trk receptors are less expressed or less active.
p75NTR Binding (bind) of in neuronal associated with stress, nerve growth factor, central nervous system, apoptosis, neurodegenerative disease and death
15) Confidence 0.14 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.83 Pain Relevance 0.08
The neurotrophins bind two classes of receptor, the common p75NTR, which is a member of the tumor necrosis factor receptor family [2,3], and the tropomyosin-related kinase (Trk) receptors, members of the large tyrosine kinase receptor family [4].
p75NTR Binding (bind) of associated with necrosis and cancer
16) Confidence 0.12 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.20 Pain Relevance 0.15
For example, pro-NGF does not bind TrkA, but causes cell death by binding to p75NTR [7,8].
p75NTR Binding (binding) of associated with nerve growth factor and death
17) Confidence 0.12 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.29 Pain Relevance 0.41
NT3 may also act via trkA. p75 is a low affinity neurotrophin receptor
p75 Binding (affinity) of associated with neurotrophin 3
18) Confidence 0.09 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.08 Pain Relevance 0.27
The mitochondrial cascade leading to activation of the initiator caspase -9, and then caspases -3 and -7, has been found to be mediated by a JNK-dependent pathway following interaction of p75 with NRAGE [159].
p75 Binding (interaction) of
19) Confidence 0.08 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.32 Pain Relevance 0.05
The protein product of NGFRAP1 interacts with p75 (NTR).
p75 Binding (interacts) of
20) Confidence 0.08 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2956710 Disease Relevance 1.30 Pain Relevance 0

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