INT48312

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 72
Total Number 74
Disease Relevance 38.21
Pain Relevance 22.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NTRK1) endosome (NTRK1) plasma membrane (NTRK1)
Anatomy Link Frequency
neurons 7
nerve 5
sensory neurons 3
DRG 3
endocrine cells 2
NTRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 214 100.00 Very High Very High Very High
nociceptor 49 100.00 Very High Very High Very High
Trk A 7 100.00 Very High Very High Very High
nMDA receptor 6 100.00 Very High Very High Very High
trk C 1 100.00 Very High Very High Very High
Trigeminal ganglion neurons 2 99.28 Very High Very High Very High
dorsal root ganglion 29 99.26 Very High Very High Very High
qutenza 146 99.16 Very High Very High Very High
Inflammation 128 99.14 Very High Very High Very High
substance P 15 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 1015 100.00 Very High Very High Very High
Aggression 17 100.00 Very High Very High Very High
Colon Cancer 3 100.00 Very High Very High Very High
Apoptosis 138 99.92 Very High Very High Very High
Motor Neuron Diseases 37 99.86 Very High Very High Very High
Nociception 58 99.84 Very High Very High Very High
Pancreatic Cancer 51 99.84 Very High Very High Very High
Ganglion Cysts 55 99.82 Very High Very High Very High
Lung Cancer 547 99.74 Very High Very High Very High
Prostate Cancer 11 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Somatic rearrangements of NTRK1, producing chimeric oncogenes with constitutive tyrosine kinase activity, have been detected in a consistent fraction of papillary thyroid tumors.
Gene_expression (producing) of NTRK1 in thyroid associated with thyroid neoplasm
1) Confidence 0.78 Published 2006 Journal Cancer Lett. Section Abstract Doc Link 16242838 Disease Relevance 0.73 Pain Relevance 0.09
DIE was innervated abundantly by sensory Adelta, sensory C, cholinergic and adrenergic nerve fibres; NGF, Trk-A and p75 were strongly expressed in endometriotic glands and stroma of DIE.
Gene_expression (expressed) of Trk-A in stroma
2) Confidence 0.75 Published 2009 Journal Hum. Reprod. Section Body Doc Link 19151028 Disease Relevance 0.07 Pain Relevance 0
While the DRG culture conditions utilised in our study included NGF and may therefore represent increased expression of TRPV1 in trk-A-expressing fibres, our findings are nonetheless relevant as increased NGF levels occur physiologically during inflammation [55].
Gene_expression (expressing) of trk-A associated with inflammation
3) Confidence 0.75 Published 2006 Journal Mol Pain Section Body Doc Link PMC1553434 Disease Relevance 0.19 Pain Relevance 1.00
We recently found that the activated nerve growth factor (NGF) receptor p-TrkA is more frequently expressed compared to p75, another NGF receptor that belongs to the tumor necrosis factor family, in MM, and that p-TrkA expression is significantly higher in peritoneal MM compared to their pleural counterparts (Figures 1-D, 1-E).
Gene_expression (expressed) of TrkA in nerve associated with necrosis, lung cancer, nerve growth factor and cancer
4) Confidence 0.75 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.01 Pain Relevance 0.15
In addition, p-TrkA expression was marginally higher in effusions, while p75 expression was significantly higher in solid MM (Davidson, 2004).
Gene_expression (expression) of TrkA associated with lung cancer
5) Confidence 0.75 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.14 Pain Relevance 0.13
In the nearby uninjured L4 DRG, TRPA1 mRNA expression increased in trkA-expressing small-to-medium diameter neurons from the 1st to 14th day after the L5 SNL.
Gene_expression (expressing) of trkA in DRG associated with dorsal root ganglion and eae
6) Confidence 0.75 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16546170 Disease Relevance 1.33 Pain Relevance 1.02
Recently it has been observed that a subpopulation of gut endocrine cells in vertebrates express Trk-like proteins, suggesting that neurotrophins could regulate the synthesis and storage of amines and peptides of these cells.
Gene_expression (express) of Trk in endocrine cells
7) Confidence 0.75 Published 1999 Journal Anat. Rec. Section Abstract Doc Link 10521780 Disease Relevance 0 Pain Relevance 0
The adjacent nerves expressed the high-affinity NGF receptor trk-A.
Gene_expression (expressed) of trk in nerves associated with nerve growth factor
8) Confidence 0.75 Published 2002 Journal J. Pathol. Section Abstract Doc Link 12115873 Disease Relevance 0.85 Pain Relevance 1.35
Immunohistochemistry and in situ hybridization have been used to investigate expression of the candidate neurotrophin, nerve growth factor (NGF), and its high- and low-affinity receptors trk-A and p75, respectively, in painful IVD excised for the management of low back pain.
Spec (investigate) Gene_expression (expression) of trk in IVD associated with low back pain, pain, nerve growth factor and backache
9) Confidence 0.75 Published 2002 Journal J. Pathol. Section Abstract Doc Link 12115873 Disease Relevance 0.71 Pain Relevance 1.12
The selective action of neurotrophins is achieved via restricted expression of high affinity trk receptors through which the neurotrophins act.
Gene_expression (expression) of trk
10) Confidence 0.75 Published 2002 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 12589921 Disease Relevance 0.09 Pain Relevance 0.29
We have now detected, by immunohistochemistry, beta3-subunits in 82% of small/medium and 67% of large diameter sensory neurons in intact human dorsal root ganglia: 54% of beta3 small/medium neurons were NGF receptor trkA negative.
Neg (negative) Gene_expression (negative) of trkA in sensory neurons
11) Confidence 0.75 Published 2004 Journal Neuroreport Section Abstract Doc Link 15232296 Disease Relevance 0.27 Pain Relevance 0.45
We recently found that the activated nerve growth factor (NGF) receptor p-TrkA is more frequently expressed compared to p75, another NGF receptor that belongs to the tumor necrosis factor family, in MM, and that p-TrkA expression is significantly higher in peritoneal MM compared to their pleural counterparts (Figures 1-D, 1-E).
Gene_expression (expression) of TrkA in nerve associated with necrosis, lung cancer, nerve growth factor and cancer
12) Confidence 0.75 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.03 Pain Relevance 0.15
Trk receptors are expressed in hFOB cells, as determined both by reverse transcription-PCR and Western blots.
Gene_expression (expressed) of Trk
13) Confidence 0.75 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861369 Disease Relevance 0.87 Pain Relevance 0.14
It appears that in pancreatic cancer cells the growth effects of NGF depend on the expression levels and the ratio of TrkA and p75NGFR.
Gene_expression (expression) of TrkA associated with nerve growth factor and pancreatic cancer
14) Confidence 0.75 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 15944784 Disease Relevance 1.10 Pain Relevance 0.49
In conclusion, our study found that the expression of TrkA in pancreatic cancer is a marker of tumor aggressiveness.
Gene_expression (expression) of TrkA associated with cancer, aggression and pancreatic cancer
15) Confidence 0.75 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 15944784 Disease Relevance 1.02 Pain Relevance 0.42
Moreover, it has also been detected that high levels of TrkA expression have a more favorable overall survival prognosis in breast cancer patients, but the relationships between the two receptors according to the prognosis in pancreatic cancer patients are unknown.
Gene_expression (expression) of TrkA associated with pancreatic cancer and breast cancer
16) Confidence 0.75 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 15944784 Disease Relevance 0.71 Pain Relevance 0.24
Regarding this, high TrkA expression levels exhibited more frequent perineural invasion and a higher degree of pain, whereas the results of p75NGFR are on the contrary.
Gene_expression (expression) of TrkA associated with pain
17) Confidence 0.75 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 15944784 Disease Relevance 1.24 Pain Relevance 0.46
TRKA, a receptor tyrosine kinase cloned from a human colon cancer was later found to be expressed in the nervous system and phosphorylated in response to NGF.
Gene_expression (expressed) of TRKA in nervous system associated with nerve growth factor and colon cancer
18) Confidence 0.68 Published 1997 Journal Jpn. J. Hum. Genet. Section Abstract Doc Link 9290260 Disease Relevance 0.26 Pain Relevance 0.34
A splice mutation and a missense mutation were detected in the TRKA and PKLR genes from the homozygous proband, respectively.
Gene_expression (detected) of TRKA
19) Confidence 0.67 Published 2001 Journal Hum. Mutat. Section Abstract Doc Link 11668614 Disease Relevance 0.86 Pain Relevance 0.55
Our results demonstrated that NTRK1 is contained within 25 Kb of DNA and is organized in 17 exons, one of which is alternatively spliced.
Gene_expression (contained) of NTRK1
20) Confidence 0.66 Published 1996 Journal Oncogene Section Abstract Doc Link 8957089 Disease Relevance 0.68 Pain Relevance 0.09

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